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Actemra ACTPen
Actemra ACTPen, the generic version of Actemra, is a biologic medication prescribed for the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, and giant cell arteritis. It belongs to the class of interleukin-6 (IL-6) receptor antagonists, which work by inhibiting the activity of IL-6, a protein that contributes to inflammation and joint damage in autoimmune diseases. Actemra ACTPen is administered via subcutaneous injection and helps reduce symptoms such as pain, swelling, and joint damage in patients with these conditions.
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Frequently Asked Questions
How do I store Actemra ACTPen?
Store Actemra ACTPen in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze it, and keep it in its original carton to protect it from light. Allow it to reach room temperature for 30 minutes before using it.
Can I travel with Actemra ACTPen?
Yes, you can travel with Actemra ACTPen, but it should be kept in a cooler with ice packs to maintain the proper temperature. Be sure to carry it in your carry-on luggage if flying, and check with your airline for specific guidelines.
How long does it take for Actemra to start working?
Some patients may start to feel relief from their symptoms within a few weeks of starting Actemra, but it can take several months for the full effects to be seen. It’s important to continue taking the medication as prescribed and to attend all follow-up appointments with your healthcare provider.
Can I take Actemra ACTPen if I am pregnant or breastfeeding?
If you are pregnant or planning to become pregnant, consult your healthcare provider before starting Actemra ACTPen. There is limited data on its use during pregnancy, so the risks and benefits should be carefully considered. It is also not known if Actemra passes into breast milk, so breastfeeding while on this medication should be discussed with your doctor.
What should I do if I miss a dose?
If you miss a dose of Actemra ACTPen, take it as soon as you remember, unless it’s close to the time of your next scheduled dose. Do not take two doses at the same time to make up for the missed one. Contact your healthcare provider if you are unsure of what to do.
Comprehensive Drug Guide
How Does Actemra ACTPen Work?
Actemra ACTPen targets and blocks a specific protein in the body called interleukin-6 (IL-6). By blocking IL-6, Actemra helps reduce the inflammation and damage that occur in conditions like rheumatoid arthritis, making it easier to manage symptoms like pain and swelling.
Common Dosages
Actemra ACTPen is available as a prefilled autoinjector with the following common dosage strengths:
- 162 mg/0.9 mL solution for subcutaneous injection.
This dosage is used for self-administration at home, making it convenient for patients managing chronic conditions.
For adults with rheumatoid arthritis, the typical dosing of Actemra ACTPen is 162 mg injected subcutaneously once every week or every two weeks, depending on the patient's individual needs and the severity of the condition. For other conditions such as giant cell arteritis, the dosing may vary, and it’s important to follow the specific instructions provided by the healthcare provider.
Typical Dosing
Pediatric Dosing
This medication is generally not recommended for pediatric patients in the form of an ACTPen.
Who Shouldn't Take Actemra ACTPen?
Actemra ACTPen should not be used in patients with a known hypersensitivity to tocilizumab or any of its components. It is also contraindicated in individuals with active infections, such as tuberculosis or other serious infections, as Actemra can suppress the immune system, making it harder to fight off infections.
Advice From The Pharmacist
When using Actemra ACTPen, make sure to follow the instructions provided for proper self-injection. Always rotate injection sites to avoid irritation and never inject into areas that are red, swollen, or bruised. Store the autoinjector in the refrigerator, but allow it to reach room temperature before injecting. If you notice any signs of infection, such as fever, chills, or persistent cough, contact your healthcare provider immediately. Regular blood tests may be required to monitor your response to the medication and to check for potential side effects.
Side Effects of Actemra ACTPen
Common Side Effects
Common side effects of Actemra ACTPen include injection site reactions (such as redness, swelling, or pain), upper respiratory tract infections, headaches, and increased blood pressure. Serious side effects may include severe infections, liver damage, and gastrointestinal perforations. If you experience any severe symptoms, such as abdominal pain, jaundice, or signs of an allergic reaction (e.g., difficulty breathing, rash), seek medical attention immediately.
Risks and Warnings of Actemra ACTPen
The major risks associated with Actemra ACTPen include an increased risk of serious infections, liver enzyme elevations, and potential gastrointestinal perforations. Patients should be screened for tuberculosis before starting treatment and monitored regularly for signs of infection. Additionally, this medication may increase cholesterol levels, so regular lipid monitoring is advised. It's important to discuss the potential risks with your healthcare provider, especially if you have a history of liver disease, high cholesterol, or gastrointestinal issues.
Interactions with Actemra ACTPen
Common Drug Interactions
Actemra ACTPen may interact with other medications that affect the immune system, such as biologics or immunosuppressants, and can also affect how your body processes certain drugs like warfarin or statins. Avoid live vaccines during treatment with Actemra, as the medication may reduce the effectiveness of the vaccine and increase the risk of infection. Always inform your healthcare provider of all medications and supplements you are taking before starting Actemra ACTPen.
Alternatives to Actemra ACTPen
Alternative treatments to Actemra ACTPen for rheumatoid arthritis or other autoimmune conditions may include other biologic agents such as adalimumab (Humira), etanercept (Enbrel), or infliximab (Remicade). Non-biologic DMARDs (disease-modifying antirheumatic drugs) like methotrexate or sulfasalazine may also be considered, depending on the patient's condition and tolerance.
