Browse Medications by Therapeutic Class: Sleep Disorder Agents
Written by Amar Lunagaria
Pharm.D • NiHowdy Founder
Reviewed by James Wong
Pharm.D • NiHowdy Founder
Updated Jan 27, 2025
•Published Jan 15, 2025
Fact checkedWhat are Sleep Disorder Agents?
How do Sleep Disorder Agents work?
- Hypnotics: Induce drowsiness and help initiate or maintain sleep.
- Wakefulness-promoting agents: Treat excessive daytime sleepiness in conditions like narcolepsy.
- Dopamine agonists: Relieve symptoms of restless legs syndrome by improving dopamine function.
- Melatonin receptor agonists: Regulate the body's internal clock to improve sleep-wake cycles.
What conditions do Sleep Disorder Agents treat?
- Insomnia: Difficulty falling or staying asleep.
- Narcolepsy: Excessive daytime sleepiness and sudden sleep attacks.
- Restless legs syndrome (RLS): Uncomfortable leg sensations that disrupt sleep.
- Sleep apnea: In some cases, adjunctive therapies are used alongside CPAP.
- Circadian rhythm disorders: Jet lag or shift work sleep disorder.
Common medications in Sleep Disorder Agents
- Zolpidem (Ambien): A hypnotic for short-term insomnia relief.
- Eszopiclone (Lunesta): Helps with falling and staying asleep.
- Modafinil (Provigil): Promotes wakefulness in narcolepsy and sleep apnea.
- Ropinirole (Requip): Relieves restless legs syndrome.
- Ramelteon (Rozerem): Regulates sleep-wake cycles by targeting melatonin receptors.
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Benefits of Sleep Disorder Agents
- Improved ability to fall and stay asleep.
- Enhanced daytime alertness and reduced fatigue.
- Better quality of life through restorative sleep and increased energy levels.
Side effects of Sleep Disorder Agents
- Drowsiness or grogginess during the day.
- Dizziness or balance issues.
- Rarely, complex sleep behaviors like sleepwalking or sleep driving (with hypnotics).
- Dependency risk with prolonged use of certain medications.
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