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Zyvox
Zyvox (linezolid) is an antibiotic used to treat serious bacterial infections that are resistant to other antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) infections. It belongs to the oxazolidinone class of antibiotics, which works by inhibiting bacterial protein synthesis, effectively stopping bacterial growth. Zyvox is commonly prescribed for infections such as pneumonia, skin infections, and infections caused by resistant gram-positive bacteria.
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Frequently Asked Questions
How long does it take for Zyvox to start working?
Improvement in symptoms may be noticed within the first few days of starting treatment, but it’s essential to complete the full course of Zyvox even if you start feeling better early on.
Can Zyvox cause serotonin syndrome?
Yes, Zyvox can increase the risk of serotonin syndrome, particularly when taken with other medications that affect serotonin levels, such as antidepressants like SSRIs or SNRIs.
Can I drink alcohol while taking Zyvox?
While moderate alcohol consumption is not strictly contraindicated, it's best to avoid alcohol, as it can exacerbate some side effects such as dizziness and stomach upset.
Can Zyvox be used to treat viral infections?
No, Zyvox is an antibiotic and is only effective against bacterial infections. It will not work for viral infections such as the common cold or flu.
What should I do if I miss a dose of Zyvox?
Take the missed dose as soon as you remember, unless it is almost time for the next dose. Do not take two doses at once to make up for a missed dose.
Comprehensive Drug Guide
How Does Zyvox Work?
Zyvox works by inhibiting bacterial protein synthesis. It binds to a specific site on the bacterial ribosome, which prevents the bacteria from producing proteins necessary for their growth and replication. This action effectively stops the infection from spreading and allows the immune system to eliminate the bacteria.
Common Dosages
- Tablets: 600 mg
- Oral suspension: 100 mg/5 mL
- IV infusion: 600 mg every 12 hours
Typical Dosing
- For skin infections and pneumonia: The typical dose is 600 mg taken every 12 hours for 10-14 days.
- For VRE infections: The treatment course can extend to 14-28 days depending on the severity of the infection.
Typical Dosing
FDA Approved Indications
- Methicillin-resistant Staphylococcus aureus (MRSA) infections
- Vancomycin-resistant Enterococcus (VRE) infections
- Nosocomial pneumonia
- Community-acquired pneumonia
- Complicated skin and soft tissue infections
- Uncomplicated skin and soft tissue infections (caused by susceptible gram-positive bacteria)
Who Shouldn't Take Zyvox?
- Known hypersensitivity to linezolid or any of its components.
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of taking an MAOI due to the risk of serotonin syndrome.
Advice From The Pharmacist
- Zyvox can be taken with or without food, but take it at evenly spaced intervals to maintain consistent levels of the drug in your body.
- Avoid consuming large amounts of tyramine-rich foods (such as aged cheeses, cured meats, and fermented products) while taking Zyvox, as it may cause dangerous increases in blood pressure.
- If taking the oral suspension, shake the bottle well before each dose to ensure the suspension is properly mixed.
- Complete the full course of treatment even if you start feeling better to avoid bacterial resistance.
Side Effects of Zyvox
Common Side Effects
- Diarrhea
- Nausea and vomiting
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Thrombocytopenia (low platelet count)
- Serotonin syndrome (when taken with serotonergic drugs)
- Lactic acidosis
- Peripheral and optic neuropathy (with long-term use)
Risks and Warnings of Zyvox
- Thrombocytopenia: Zyvox may cause a reduction in platelet counts, particularly if used for more than 14 days. Blood counts should be monitored during treatment.
- Serotonin Syndrome: Zyvox may increase serotonin levels when taken with SSRIs, SNRIs, or other serotonergic drugs, leading to serotonin syndrome, a potentially life-threatening condition.
- Neuropathy: Long-term use of Zyvox can cause peripheral neuropathy (nerve damage), particularly if the treatment extends beyond 28 days.
- Lactic Acidosis: Zyvox can cause a buildup of lactic acid in the blood, leading to lactic acidosis. Symptoms may include unusual fatigue, muscle pain, and difficulty breathing.
Interactions with Zyvox
Common Drug Interactions
- Serotonergic drugs: Zyvox should be used cautiously with medications like SSRIs, SNRIs, triptans, and tramadol due to the increased risk of serotonin syndrome.
- MAOIs: Zyvox is contraindicated in patients taking monoamine oxidase inhibitors or those who have used them within the last 14 days.
- Tyramine-containing foods: Foods rich in tyramine, such as aged cheeses and cured meats, should be limited, as they can lead to dangerous spikes in blood pressure when consumed with Zyvox.
Alternatives to Zyvox
- Vancomycin: An antibiotic commonly used to treat resistant bacterial infections, including MRSA.
- Daptomycin (Cubicin): An antibiotic used for skin and bloodstream infections caused by resistant bacteria like MRSA.
- Clindamycin: Another antibiotic that can be used to treat serious bacterial infections, though it has different activity from Zyvox.