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Zovia 1/35E (28)
Zovia 1/35E (generic name: ethynodiol diacetate and ethinyl estradiol) is a combined oral contraceptive pill used to prevent pregnancy. It contains a combination of estrogen (ethinyl estradiol) and progestin (ethynodiol diacetate), which work together to prevent ovulation, thicken cervical mucus, and alter the uterine lining to prevent implantation. Zovia 1/35E is also sometimes used to regulate menstrual cycles, reduce the risk of ovarian cysts, and treat acne in women seeking contraception.
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Frequently Asked Questions
How soon after starting Zovia 1/35E am I protected against pregnancy?
If you start Zovia on the first day of your period, you are protected immediately. If started on any other day, use backup contraception (e.g., condoms) for the first 7 days.
What should I do if I miss a pill?
If you miss one pill, take it as soon as you remember and take the next pill at your regular time. If you miss two or more pills, follow the instructions in the leaflet and use backup contraception for 7 days.
Can Zovia 1/35E help with acne?
Yes, Zovia 1/35E can help reduce acne for some women by regulating hormones, but it is not specifically approved for acne treatment.
Can I use Zovia 1/35E if I have migraines?
If you experience migraines with aura, Zovia 1/35E may not be recommended due to the increased risk of stroke. Consult your healthcare provider for advice.
Can Zovia 1/35E cause weight gain?
Some women may experience weight changes while using Zovia 1/35E, but significant weight gain is uncommon. Most women do not experience substantial changes in weight.
Comprehensive Drug Guide
How Does Zovia 1/35E (28) Work?
- Inhibiting ovulation: Prevents the release of an egg from the ovaries.
- Thickening cervical mucus: Makes it harder for sperm to reach an egg.
- Altering the uterine lining: Makes the uterine lining less favorable for implantation.
Common Dosages
- 21 active tablets: 1 mg ethynodiol diacetate / 35 mcg ethinyl estradiol.
- 7 placebo (inactive) tablets: Taken during the last 7 days of the cycle.
Typical Dosing
- Take one active tablet daily for 21 consecutive days, followed by one inactive tablet daily for 7 days.
- Begin a new pack after finishing the 28 tablets, regardless of whether bleeding has started or stopped.
- Try to take the pill at the same time every day to maintain effectiveness.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy in women who elect to use oral contraceptives.
Who Shouldn't Take Zovia 1/35E (28)?
- History of thromboembolic events (e.g., blood clots, deep vein thrombosis, or pulmonary embolism).
- Uncontrolled hypertension or severe cardiovascular conditions.
- Liver disease or liver tumors.
- Breast cancer or other hormone-sensitive cancers.
- Smokers over 35 years of age, due to the increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Zovia 1/35E at the same time every day to ensure consistent hormone levels and effective contraception.
- If you miss a dose, take it as soon as you remember. If you miss two or more pills, follow the instructions in your pack’s leaflet and use backup contraception for the next 7 days.
- If vomiting or diarrhea occurs within a few hours of taking a pill, treat it as a missed dose and take another pill.
- Avoid smoking while on Zovia 1/35E, as it increases the risk of serious cardiovascular side effects, especially in women over 35 years of age.
Side Effects of Zovia 1/35E (28)
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Weight changes
- Breakthrough bleeding (spotting)
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke
- Heart attack
- Liver problems (yellowing of the skin or eyes)
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Zovia 1/35E (28)
- Blood Clot Risk: Like other combined oral contraceptives, Zovia 1/35E increases the risk of blood clots, especially in women who smoke, are over 35, or have other risk factors like obesity or a family history of clotting disorders.
- Cardiovascular Risk: Increased risk of stroke, heart attack, and hypertension is associated with the use of oral contraceptives, especially in women who smoke or have cardiovascular risk factors.
- Liver Problems: Long-term use of combined hormonal contraceptives may increase the risk of liver tumors or liver-related issues.
Interactions with Zovia 1/35E (28)
Common Drug Interactions
- Antibiotics: Some antibiotics, such as rifampin, may reduce the effectiveness of Zovia 1/35E, requiring backup contraception during and for 7 days after treatment.
- Anticonvulsants: Medications like phenytoin and carbamazepine can decrease the effectiveness of oral contraceptives.
- St. John’s Wort: This herbal supplement may reduce the effectiveness of Zovia 1/35E.
Alternatives to Zovia 1/35E (28)
- Loestrin 24 Fe: A low-dose combination oral contraceptive similar to Zovia 1/35E.
- Ortho Tri-Cyclen: A combination oral contraceptive that also helps treat acne.
- NuvaRing: A vaginal ring that releases hormones to prevent pregnancy.
- Depo-Provera: A progestin-only injectable contraceptive given every three months.
