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Zafemy
Zafemy is a transdermal contraceptive patch that contains ethinyl estradiol and norelgestromin, a combination of estrogen and progestin. It is used for birth control to prevent pregnancy. The patch releases hormones through the skin into the bloodstream, inhibiting ovulation (the release of an egg) and making the uterine lining less favorable for implantation. Zafemy also thickens cervical mucus, making it more difficult for sperm to enter the uterus.
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Frequently Asked Questions
How soon does Zafemy start working?
If you start Zafemy on the first day of your period, it is effective immediately. If started on any other day, use backup contraception (e.g., condoms) for the first 7 days.
What should I do if the patch falls off?
If the patch falls off and it has been less than 24 hours, reapply it or use a new one immediately. If it has been off for more than 24 hours, use a new patch and backup contraception for the next 7 days.
Can I wear the patch while swimming or exercising?
Yes, you can wear the patch while swimming or exercising, but prolonged exposure to water or excessive sweating may reduce its adhesion. Check the patch regularly to ensure it remains securely in place.
Can I use Zafemy if I have a history of migraines?
If you experience migraines with aura, you should not use Zafemy due to an increased risk of stroke. Consult your healthcare provider for alternative contraceptive options.
Can Zafemy cause weight gain?
Some women may experience weight changes while using Zafemy, but significant weight gain is uncommon.
Comprehensive Drug Guide
How Does Zafemy Work?
- Inhibiting ovulation: Prevents the release of an egg from the ovaries.
- Thickening cervical mucus: Makes it harder for sperm to reach an egg.
- Altering the uterine lining: Makes the lining of the uterus less receptive to implantation.
Common Dosages
- 0.035 mg of ethinyl estradiol per day.
- 0.15 mg of norelgestromin per day.
Typical Dosing
- The Zafemy patch is applied once a week for three consecutive weeks, followed by a patch-free week (week 4) during which a withdrawal bleed occurs.
- Apply the patch to the buttock, abdomen, upper arm, or back, avoiding irritated or broken skin.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy in women of reproductive age.
Who Shouldn't Take Zafemy?
- History of thromboembolic events (e.g., blood clots, deep vein thrombosis, or pulmonary embolism).
- Uncontrolled hypertension or severe heart conditions.
- Liver disease or liver tumors.
- Breast cancer or other hormone-sensitive cancers.
- Smokers over 35 years of age due to the increased risk of cardiovascular events.
Advice From The Pharmacist
- Apply the patch to clean, dry, and intact skin: Avoid applying lotion or other products before applying the patch.
- If the patch becomes loose or falls off, apply a new one as soon as possible. If it's off for more than 24 hours, use backup contraception (e.g., condoms) for the next 7 days.
- Rotate the application site to avoid skin irritation. Do not apply the patch to the same spot consecutively.
- Avoid exposure to heat or water for extended periods, as this may reduce the effectiveness of the patch.
- Do not skip the patch-free week unless instructed by your healthcare provider.
Side Effects of Zafemy
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Mood changes
- Menstrual changes (e.g., spotting or breakthrough bleeding)
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke
- Heart attack
- Liver problems (jaundice or liver tumors)
Risks and Warnings of Zafemy
- Increased Risk of Blood Clots: Like other hormonal contraceptives, Zafemy increases the risk of blood clots. Women over 35 who smoke are at an especially higher risk and should not use this form of contraception.
- Cardiovascular Risk: There is an increased risk of stroke and heart attack for users, particularly in women who smoke or have other risk factors for cardiovascular disease.
- Liver Problems: Long-term use of hormonal contraceptives has been linked to an increased risk of liver tumors and elevated liver enzymes.
Interactions with Zafemy
Common Drug Interactions
- CYP3A4 inducers: Medications that induce CYP3A4 (e.g., rifampin, carbamazepine) may reduce the effectiveness of Zafemy.
- Antibiotics and antifungals: Certain antibiotics and antifungals (e.g., griseofulvin) can reduce the efficacy of hormonal contraceptives.
- HIV medications: Certain antiretroviral medications can interfere with the effectiveness of Zafemy.
Alternatives to Zafemy
- Oral contraceptive pills: Combination birth control pills that deliver similar hormones via oral administration.
- NuvaRing: A vaginal ring that releases hormones to prevent pregnancy.
- Depo-Provera: A progestin-only injection given every three months.
- Intrauterine devices (IUDs): Long-acting reversible contraceptives like Mirena or Paragard.
