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YF-VAX
YF-VAX is a live-attenuated vaccine used to prevent yellow fever, a serious viral infection transmitted by mosquitoes. Yellow fever is prevalent in parts of Africa and South America, and the vaccine is recommended for travelers to these areas and people living in endemic regions. YF-VAX stimulates the immune system to produce antibodies against the yellow fever virus, providing long-term protection.
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Frequently Asked Questions
How long does YF-VAX provide protection?
YF-VAX provides long-term protection, typically for 10 years or more. In most cases, a single dose provides lifetime immunity, though some countries may require a booster dose for entry.
Can I get YF-VAX if I have a weakened immune system?
YF-VAX is not recommended for individuals with weakened immune systems, such as those with HIV, cancer, or those taking immunosuppressive medications, due to the risk of severe side effects.
What should I do if I experience side effects from YF-VAX?
Mild side effects like fever, headache, and muscle aches are common and usually resolve on their own. If you experience severe symptoms such as difficulty breathing, swelling, or neurological changes, seek medical attention immediately.
Can I receive other vaccines at the same time as YF-VAX?
Yes, other vaccines can be administered with YF-VAX, but some live vaccines should either be given on the same day or spaced 4 weeks apart to avoid interference with the immune response.
Is YF-VAX safe during pregnancy?
YF-VAX is generally not recommended during pregnancy unless travel to a high-risk area is unavoidable. Consult your healthcare provider if you are pregnant or planning to become pregnant before receiving the vaccine.
Comprehensive Drug Guide
How Does YF-VAX Work?
YF-VAX contains a weakened form of the yellow fever virus. When administered, the body recognizes the virus and mounts an immune response, producing antibodies that protect against future infection. This immune response provides long-lasting protection, typically for 10 years or more.
Common Dosages
- 0.5 mL subcutaneous injection, typically given at least 10 days before travel to an area where yellow fever is a risk.
Typical Dosing
- For yellow fever prevention: A single 0.5 mL dose of YF-VAX provides protection. In most cases, a booster dose is not required, although some countries may still require proof of recent vaccination.
Typical Dosing
FDA Approved Indications
- Yellow fever in individuals aged 9 months and older who are traveling to or living in areas where yellow fever is endemic or who are at risk of yellow fever virus exposure.
Who Shouldn't Take YF-VAX?
- Severe allergy to eggs, chicken proteins, or gelatin
- Immunocompromised individuals (e.g., due to HIV, cancer, or immunosuppressive therapy)
- Infants younger than 6 months of age
- History of severe allergic reaction to a previous dose of YF-VAX or any component of the vaccine
- Thymus disorders (e.g., myasthenia gravis, thymoma)
Advice From The Pharmacist
- YF-VAX should be administered at least 10 days before travel to provide sufficient time for the body to develop immunity.
- A Yellow Fever Vaccination Certificate may be required for entry into certain countries. Ensure you receive this certificate from your healthcare provider after vaccination.
- Mild side effects like headache, muscle pain, and fever may occur within a few days of receiving the vaccine. These typically resolve on their own.
- Inform your healthcare provider if you are pregnant, breastfeeding, or have any weakened immune conditions before receiving the vaccine.
Side Effects of YF-VAX
Common Side Effects
- Mild fever
- Headache
- Muscle aches
- Redness or soreness at the injection site
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Yellow fever vaccine-associated viscerotropic disease (YEL-AVD): A life-threatening condition that causes multi-organ failure.
- Yellow fever vaccine-associated neurotropic disease (YEL-AND): A neurological complication that can result in encephalitis or Guillain-Barré syndrome.
Risks and Warnings of YF-VAX
- Severe Allergic Reactions: YF-VAX may cause severe allergic reactions in individuals with a history of egg or chicken protein allergy. Inform your healthcare provider if you have such allergies before receiving the vaccine.
- Viscerotropic Disease (YEL-AVD): This rare but serious complication can occur after yellow fever vaccination and involves multi-organ failure. The risk is higher in older adults and individuals with thymus disease.
- Neurotropic Disease (YEL-AND): This rare neurological condition may cause encephalitis or Guillain-Barré syndrome and is more likely to occur in individuals over 60 years of age or those with weakened immune systems.
Interactions with YF-VAX
Common Drug Interactions
- Immunosuppressive medications (e.g., corticosteroids, chemotherapy): These medications can reduce the effectiveness of YF-VAX, and the vaccine should generally be avoided in immunocompromised individuals.
- Other live vaccines: If multiple live vaccines are needed, they should either be administered on the same day or spaced at least 4 weeks apart to ensure optimal immune response.
- Antiviral medications: Some antiviral medications may interfere with the effectiveness of YF-VAX. Consult your healthcare provider if you are taking antivirals.
Alternatives to YF-VAX
- Avoidance of mosquito bites: Wearing protective clothing, using mosquito repellents, and staying in well-screened areas can reduce the risk of yellow fever in endemic regions.
- Stamaril: Another yellow fever vaccine used in some countries where YF-VAX is not available or in short supply.
