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Xipere
Xipere, the brand name for triamcinolone acetonide injectable suspension, is a corticosteroid used to treat macular edema associated with uveitis (inflammation of the uvea, the middle layer of the eye). This medication is specifically designed for administration through a suprachoroidal injection to deliver the drug directly to the back of the eye, targeting inflammation more precisely while minimizing side effects to other parts of the body. It helps reduce swelling and inflammation in the eye, improving vision in patients with uveitic macular edema.
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Frequently Asked Questions
How long does it take for Xipere to start working?
Xipere begins working to reduce inflammation and edema soon after injection, but the exact timing for improvement in vision may vary. Many patients experience improvement in symptoms within several weeks of treatment.
How long does the effect of Xipere last?
The effects of Xipere can last several months, but the duration depends on the severity of the condition and the patient’s individual response. Follow-up appointments are necessary to monitor treatment progress and determine if additional injections are needed.
Can Xipere cause cataracts?
Yes, long-term or repeated use of corticosteroids, including Xipere, can lead to cataracts. Your eye doctor will monitor you for signs of cataract formation over time.
What should I do if I experience eye pain after the Xipere injection?
Mild discomfort is common after the injection, but if you experience significant or worsening eye pain, redness, or changes in vision, contact your healthcare provider immediately, as this could be a sign of infection or other complications.
Can I drive after receiving a Xipere injection?
You may experience temporary blurred vision after the injection, so it’s advisable to have someone drive you home and avoid activities that require clear vision until your vision returns to normal.
Comprehensive Drug Guide
How Does Xipere Work?
Xipere works by delivering triamcinolone acetonide, a potent corticosteroid, directly into the suprachoroidal space of the eye, where it acts to reduce inflammation and edema (swelling) in the macula. By targeting inflammation at the back of the eye, Xipere helps to decrease the fluid accumulation in the retina, improving vision in patients with uveitic macular edema. Its direct delivery to the eye minimizes systemic side effects.
Common Dosages
- Xipere is available as a 40 mg/mL injectable suspension, and the dosage is determined by the healthcare provider. It is administered using a specialized suprachoroidal injection technique.
Typical Dosing
- Xipere is administered as a single suprachoroidal injection by a healthcare professional. The dose and frequency of treatment depend on the severity of the condition and the patient’s response to therapy.
Typical Dosing
FDA Approved Indications
- Treatment of macular edema associated with uveitis in adults.
Who Shouldn't Take Xipere?
- Active eye infections (including bacterial, viral, or fungal infections in or around the eye).
- Known hypersensitivity to triamcinolone acetonide or any components of the formulation.
Advice From The Pharmacist
- Xipere is administered by a trained healthcare provider, and you should not attempt to use it at home.
- After the injection, you may be monitored for a short time for any immediate reactions or side effects.
- Report any symptoms of eye pain, blurred vision, or signs of infection (such as redness or swelling) to your healthcare provider right away.
- Avoid rubbing or pressing on your eyes after the injection, and follow your provider’s instructions for any necessary follow-up appointments.
- If you wear contact lenses, you may be asked to avoid wearing them for a period after the injection.
Side Effects of Xipere
Common Side Effects
- Temporary blurred vision
- Eye pain or discomfort at the injection site
- Increased intraocular pressure (IOP)
- Redness or swelling of the eye
- Cataract formation (with repeated corticosteroid use)
Uncommon/Severe Side Effects
- Infection in the eye
- Retinal detachment
- Significant increase in intraocular pressure, which may require treatment
- Vision loss
Risks and Warnings of Xipere
- Increased intraocular pressure (IOP): Like other corticosteroids, Xipere can cause increased pressure inside the eye, which may lead to glaucoma if left untreated. Regular monitoring of eye pressure is essential, especially after multiple injections.
- Cataract formation: Long-term use of corticosteroids in the eye increases the risk of developing cataracts, which may require surgery.
- Infection risk: Xipere can increase the risk of eye infections, and patients should be closely monitored for any signs of infection, such as redness, swelling, or pain.
- Retinal complications: In rare cases, Xipere may cause retinal detachment or other retinal complications, which can result in vision loss. Patients should report any sudden changes in vision immediately.
Interactions with Xipere
Common Drug Interactions
- Other corticosteroids: Using Xipere with other systemic or topical corticosteroids may increase the risk of side effects such as elevated intraocular pressure or cataracts.
- Immunosuppressive agents: Since corticosteroids suppress the immune system, combining Xipere with other immunosuppressive medications may increase the risk of infection.
Alternatives to Xipere
- Ozurdex (dexamethasone intravitreal implant): Another corticosteroid treatment for macular edema and uveitis delivered via intravitreal injection.
- Iluvien (fluocinolone acetonide implant): A corticosteroid implant used for diabetic macular edema and uveitis.
- Prednisolone acetate (Pred Forte): A corticosteroid eye drop used for uveitis and other inflammatory conditions of the eye.
- Methotrexate or other immunosuppressants: Systemic treatments that may be used for managing uveitis and associated complications.
