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Xhance
Xhance (generic name: fluticasone propionate nasal spray) is a corticosteroid nasal spray used to treat nasal polyps in adults. It helps reduce the size of the polyps and alleviate associated symptoms such as nasal congestion, runny nose, and postnasal drip. Xhance is unique because it is delivered via a device that allows for an exhalation delivery system (EDS), helping the medication reach deeper into the nasal passages.
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Frequently Asked Questions
How long does it take for Xhance to start working?
It may take a few days to a few weeks to start seeing significant improvement in symptoms. Continue using Xhance as prescribed for the best results.
Can I use Xhance if I have a nasal infection?
Xhance should not be used if you have an active nasal infection (bacterial, fungal, or viral) without consulting your healthcare provider, as it can worsen the infection.
What should I do if I miss a dose of Xhance?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses.
Is long-term use of Xhance safe?
Xhance is generally safe for long-term use, but regular monitoring for potential side effects, such as glaucoma, cataracts, or nasal infections, is recommended. Always follow your healthcare provider’s guidance.
Can Xhance be used for allergies?
Xhance is specifically indicated for nasal polyps. For allergic rhinitis, other nasal corticosteroids such as Flonase or Nasonex may be recommended. Always consult your healthcare provider for the appropriate treatment.
Comprehensive Drug Guide
How Does Xhance Work?
Fluticasone propionate, the active ingredient in Xhance, works by inhibiting the release of substances that cause inflammation, such as prostaglandins and leukotrienes. This reduces swelling, inflammation, and the size of nasal polyps, improving airflow through the nasal passages.
Common Dosages
- 93 mcg per spray
Typical Dosing
- The typical dosing of Xhance is one spray in each nostril twice daily (total of 372 mcg per day). The dose may be adjusted based on the patient’s response and the severity of symptoms.
Typical Dosing
FDA Approved Indications
- Treatment of nasal polyps in patients aged 18 years and older.
Who Shouldn't Take Xhance?
- Known hypersensitivity to fluticasone or any components of the formulation.
- Untreated fungal, bacterial, or viral nasal infections, as corticosteroids may worsen these conditions.
Advice From The Pharmacist
- Shake the bottle well before each use and follow the instructions for the exhalation delivery system (EDS) to ensure proper administration of the spray.
- Prime the spray by pressing down several times until a fine mist appears if the spray has not been used for more than 7 days.
- Avoid spraying into your eyes or mouth and rinse your mouth after using Xhance to reduce the risk of fungal infections in the mouth (thrush).
- Continue using the medication regularly, even if your symptoms improve. It may take a few weeks to see the full effects.
Side Effects of Xhance
Common Side Effects
- Nosebleeds
- Headache
- Nasal irritation
- Sore throat
Uncommon/Severe Side Effects
- Glaucoma or cataracts
- Slowed wound healing in the nasal passages
- Nasal septal perforation (a hole in the nasal septum)
- Increased risk of infections due to immune suppression
Risks and Warnings of Xhance
- Nasal Infections: Prolonged use of corticosteroids like Xhance can increase the risk of nasal fungal infections. If you develop persistent nasal discomfort or a sore in the nose, contact your healthcare provider.
- Nasal Septal Perforation: Improper use of nasal sprays can increase the risk of nasal septal perforation. Follow administration instructions carefully to avoid spraying directly onto the nasal septum.
- Vision Problems: Long-term use of corticosteroids may increase the risk of glaucoma or cataracts. Regular eye exams are recommended for patients on prolonged corticosteroid therapy.
Interactions with Xhance
Common Drug Interactions
- Other corticosteroids: Using multiple corticosteroid-containing medications (e.g., inhalers, topical creams) may increase the risk of systemic corticosteroid side effects.
- Immunosuppressive medications: Caution should be used when combining Xhance with other immunosuppressive drugs, as this may increase the risk of infections.
Alternatives to Xhance
- Fluticasone nasal spray (Flonase): A nasal corticosteroid used to treat allergic rhinitis and nasal polyps.
- Budesonide nasal spray (Rhinocort Aqua): A corticosteroid nasal spray used for the treatment of nasal inflammation and polyps.
- Mometasone nasal spray (Nasonex): A nasal corticosteroid for treating nasal polyps and allergic rhinitis
