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Winlevi
Winlevi (generic name: clascoterone) is a topical androgen receptor inhibitor used to treat acne vulgaris in patients aged 12 years and older. It works by blocking the effects of androgens (hormones that contribute to acne formation) on the skin's sebaceous glands, reducing oil production and inflammation. Winlevi offers a novel, non-systemic option for acne treatment and is typically applied directly to the skin.
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Frequently Asked Questions
How long does it take for Winlevi to work?
It may take several weeks of consistent use before seeing noticeable improvements in acne. Full results are typically seen after 8 to 12 weeks.
Can Winlevi be used with other acne treatments?
Yes, but it’s important to consult your healthcare provider before combining Winlevi with other acne treatments, such as retinoids or benzoyl peroxide, as this can increase the risk of skin irritation.
Will Winlevi make my skin dry?
Winlevi may cause dryness or irritation, particularly during the first few weeks of use. Using a gentle, non-comedogenic moisturizer can help alleviate these symptoms.
Can I use makeup while using Winlevi?
Yes, you can use makeup while using Winlevi. Be sure to choose non-comedogenic products that won’t clog your pores.
Is Winlevi safe during pregnancy?
The safety of Winlevi during pregnancy has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using this medication.
Comprehensive Drug Guide
How Does Winlevi Work?
Winlevi works by inhibiting androgen receptors in the skin. Androgens stimulate sebaceous (oil) glands, leading to excess oil production and the development of acne. By blocking androgen activity, Winlevi reduces the amount of oil produced by the skin, decreases inflammation, and helps prevent new acne from forming.
Common Dosages
- Winlevi is supplied as a 1% topical cream. The typical dose is to apply a thin layer of the cream to the affected areas of the skin twice daily, in the morning and evening.
Typical Dosing
- Adults and Adolescents (12 years and older): Apply a thin layer of Winlevi twice daily, once in the morning and once in the evening, to the affected areas of the skin. Avoid application to the eyes, mouth, or mucous membranes.
Typical Dosing
FDA Approved Indications
- Treatment of acne vulgaris in patients aged 12 years and older.
Who Shouldn't Take Winlevi?
- Known hypersensitivity to clascoterone or any other components of the formulation.
Advice From The Pharmacist
- Wash your face with a gentle cleanser before applying Winlevi. Pat the skin dry and apply a thin layer of the cream to the affected areas.
- Avoid using Winlevi on broken or irritated skin. If the skin becomes excessively dry or irritated, reduce the frequency of application or consult your healthcare provider.
- Use non-comedogenic (non-pore clogging) moisturizers and sunscreens to support your acne treatment while using Winlevi.
- Be patient, as it may take several weeks to see noticeable improvement in acne.
Side Effects of Winlevi
Common Side Effects
- Dry skin
- Redness or irritation at the application site
- Itching
- Peeling
Uncommon/Severe Side Effects
- Severe skin irritation or allergic reactions (rash, swelling, or difficulty breathing)
Risks and Warnings of Winlevi
- Hormonal Effects: Although Winlevi acts locally on the skin, systemic absorption is minimal. However, if unusual hormonal side effects occur, such as changes in hair growth or menstrual irregularities, consult your healthcare provider.
- Skin Reactions: Some users may experience skin irritation, dryness, or peeling. If these symptoms become severe, reduce the frequency of application or speak with your healthcare provider.
Interactions with Winlevi
Common Drug Interactions
- Other topical acne treatments: Combining Winlevi with other topical acne products, such as benzoyl peroxide or retinoids, may increase the risk of skin irritation. Use caution when layering products and consult your healthcare provider for a comprehensive acne treatment plan.
- Moisturizers and Sunscreens: Non-comedogenic moisturizers and sunscreens can be used in conjunction with Winlevi to support skin health and reduce irritation.
Alternatives to Winlevi
- Benzoyl Peroxide: A commonly used topical agent for treating mild to moderate acne by killing acne-causing bacteria.
- Topical Retinoids (adapalene, tretinoin): Vitamin A derivatives that help prevent clogged pores and reduce inflammation.
- Oral contraceptives: For women, hormonal therapy such as birth control pills can help regulate androgen levels, reducing acne.
- Spironolactone: An oral anti-androgen medication often used for hormonal acne in women.
