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Vaxchora
Vaxchora is an oral cholera vaccine used to prevent cholera caused by Vibrio cholerae serogroup O1. Cholera is a bacterial infection that causes severe diarrhea and dehydration, primarily spread through contaminated water and food in areas with poor sanitation. Vaxchora is a live, attenuated vaccine that helps the immune system produce antibodies to protect against cholera infection. It is typically recommended for travelers heading to regions where cholera is common, such as parts of Africa, Southeast Asia, and Haiti.
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Frequently Asked Questions
How long does Vaxchora provide protection?
Vaxchora provides protection against cholera for up to 3 months after vaccination.
Can I take Vaxchora with other vaccines?
Yes, Vaxchora can be taken with other vaccines, but always consult your healthcare provider. Avoid antibiotics for 14 days before and after taking the vaccine.
Can Vaxchora be given to children?
No, Vaxchora is approved only for individuals aged 18 to 64 years. There is no pediatric formulation available at this time.
Do I need to get Vaxchora if I’m traveling to a cholera-endemic area?
Yes, Vaxchora is recommended for travelers to regions where cholera is common, such as parts of Africa, Asia, and Haiti. Always consult with your healthcare provider before traveling to determine if the vaccine is appropriate for you.
Is Vaxchora effective immediately after taking it?
No, Vaxchora needs to be taken at least 10 days before travel to cholera-endemic areas to ensure full protection.
Comprehensive Drug Guide
How Does Vaxchora Work?
Vaxchora contains a live, weakened form of Vibrio cholerae serogroup O1, which stimulates the immune system to produce antibodies against the cholera bacteria. These antibodies help protect the individual from infection if they are exposed to the bacteria through contaminated food or water while traveling.
Common Dosages
- A single-dose oral suspension (100 mL) taken at least 10 days before travel to a cholera-endemic area.
Typical Dosing
- Vaxchora is administered as a single oral dose of 100 mL at least 10 days before potential exposure to cholera.
- Re-vaccination is not currently recommended, as the duration of protection has been shown to last up to 3 months.
Typical Dosing
FDA Approved Indications
- Prevention of cholera caused by Vibrio cholerae serogroup O1 in individuals aged 18 to 64 years who are traveling to cholera-endemic areas.
Who Shouldn't Take Vaxchora?
- Known severe allergic reaction (anaphylaxis) to any component of the vaccine or previous cholera vaccine.
- Individuals with a compromised immune system or who are receiving immunosuppressive therapy.
- Pregnant or breastfeeding women should consult with their healthcare provider before vaccination.
Advice From The Pharmacist
- Take Vaxchora on an empty stomach (no food or drink for at least 60 minutes before and after taking the vaccine).
- Plan ahead: Vaxchora must be taken at least 10 days before travel to cholera-endemic areas to ensure adequate protection.
- After receiving Vaxchora, avoid taking antibiotics for at least 14 days, as they may reduce the effectiveness of the vaccine.
- Even with the vaccine, continue practicing safe food and water precautions when traveling to cholera-endemic areas. Drink bottled or boiled water and avoid uncooked foods.
Side Effects of Vaxchora
Common Side Effects
- Mild gastrointestinal symptoms (diarrhea, nausea, abdominal pain)
- Fatigue
- Headache
- Vomiting
Uncommon/Severe Side Effects
- Severe allergic reactions (hives, swelling, difficulty breathing)
Risks and Warnings of Vaxchora
- Immunosuppressed Individuals: Vaxchora is a live vaccine, so it should not be given to individuals with weakened immune systems, such as those receiving chemotherapy, high-dose steroids, or biologic therapies for autoimmune diseases.
- Antibiotic Interactions: Antibiotics can interfere with the effectiveness of Vaxchora. Avoid taking antibiotics for 14 days before and after receiving the vaccine unless advised by your healthcare provider.
Interactions with Vaxchora
Common Drug Interactions
- Antibiotics: Taking antibiotics may reduce the effectiveness of Vaxchora. Avoid antibiotics for at least 14 days after vaccination.
- Immunosuppressive agents (e.g., corticosteroids, biologics): These medications may reduce the immune response to Vaxchora, making the vaccine less effective.
Alternatives to Vaxchora
- Dukoral (available outside the U.S.): An alternative oral cholera vaccine that also protects against enterotoxigenic E. coli (ETEC), another cause of traveler’s diarrhea.
- Sanitation and preventive measures: Maintaining proper hygiene, drinking clean water, and eating cooked foods are the most effective ways to prevent cholera when traveling to endemic areas.
