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Vaqta
Vaqta is a hepatitis A vaccine used to prevent infection caused by the hepatitis A virus (HAV). The hepatitis A virus can cause inflammation of the liver, leading to symptoms like jaundice, fatigue, and abdominal pain. Vaqta contains inactivated (killed) hepatitis A virus, which stimulates the body's immune system to produce antibodies that protect against future infection. It is given as a preventive vaccine and is commonly recommended for individuals traveling to areas where hepatitis A is common, as well as for individuals at higher risk for contracting the virus.
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Frequently Asked Questions
How long does Vaqta protect against hepatitis A?
After the full two-dose series, Vaqta provides long-term protection against hepatitis A, potentially lasting 20 years or more.
Can Vaqta be given with other vaccines?
Yes, Vaqta can be administered at the same time as other vaccines, including hepatitis B, MMR (measles, mumps, rubella), or varicella vaccines, but at different injection sites.
Is it safe to receive Vaqta during pregnancy?
There is limited data on the use of Vaqta in pregnant women. If vaccination is necessary due to potential exposure, your healthcare provider will evaluate the risks and benefits.
What should I do if I miss the second dose?
If you miss the second dose of Vaqta, you should schedule it as soon as possible. The second dose is important for long-term immunity, but you do not need to restart the series.
Can Vaqta prevent hepatitis A if given after exposure?
Vaqta can help prevent hepatitis A if given within 2 weeks after exposure to the virus. However, it is most effective when given before exposure.
Comprehensive Drug Guide
How Does Vaqta Work?
Vaqta works by exposing the immune system to inactivated hepatitis A virus. This prompts the immune system to create antibodies against HAV without causing disease. These antibodies protect the individual from future infection by recognizing and neutralizing the virus if exposed in the future.
Common Dosages
- Pediatric/adolescent dose (0.5 mL): For individuals aged 12 months to 18 years.
- Adult dose (1.0 mL): For individuals aged 19 years and older.
Typical Dosing
- Initial dose: One injection, given intramuscularly.
- Second dose (booster): Given 6 to 18 months after the initial dose for long-term protection.
Typical Dosing
FDA Approved Indications
- Hepatitis A infection in individuals aged 12 months and older.
It is recommended for:
- Travelers to areas where hepatitis A is common.
- Individuals with chronic liver disease.
- Individuals at increased risk of exposure to hepatitis A (e.g., healthcare workers, food handlers).
- People in communities with hepatitis A outbreaks.
Who Shouldn't Take Vaqta?
- A known severe allergic reaction (anaphylaxis) to any component of the vaccine, including neomycin.
- Acute, severe febrile illness (in which case, the vaccine should be postponed until recovery).
Advice From The Pharmacist
- Travelers: If you are planning to travel to an area where hepatitis A is common, get vaccinated at least 2 weeks before your trip to ensure adequate protection.
- The full protection of Vaqta requires two doses, so be sure to complete the booster dose 6 to 18 months after the first injection.
- Common side effects like soreness at the injection site, fatigue, or headache usually resolve within a few days.
- Store the vaccine in the refrigerator before administration, and do not freeze.
Side Effects of Vaqta
Common Side Effects
- Pain or swelling at the injection site
- Fatigue
- Headache
- Low-grade fever
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (hives, swelling, difficulty breathing)
- Fainting (associated with needle injections)
Risks and Warnings of Vaqta
- Allergic Reactions: In rare cases, severe allergic reactions can occur. Seek immediate medical attention if you experience symptoms of an allergic reaction, such as hives, swelling of the face or throat, or difficulty breathing.
- Immunocompromised Patients: The immune response may be less effective in individuals with compromised immune systems (e.g., those undergoing chemotherapy or taking immunosuppressive drugs).
- Postpone in Acute Illness: If you are experiencing an acute, severe illness, delay vaccination until you have recovered.
Interactions with Vaqta
Common Drug Interactions
- There are no significant drug interactions associated with Vaqta. However, if you are receiving immunosuppressive therapy (e.g., corticosteroids), your body’s immune response to the vaccine may be reduced. Consult your healthcare provider before vaccination if you are on these treatments.
Alternatives to Vaqta
- Havrix: Another inactivated hepatitis A vaccine, similar to Vaqta, used for preventing hepatitis A.
- Twinrix: A combination vaccine that provides protection against both hepatitis A and hepatitis B, often used for travelers needing protection from both viruses.
