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Upneeq
Upneeq (generic name: oxymetazoline hydrochloride ophthalmic solution) is a prescription eye drop used to treat acquired blepharoptosis (low-lying eyelids) in adults. This condition, often simply referred to as ptosis, causes the upper eyelid to droop, which can interfere with vision and affect the appearance of the eyes. Upneeq works by stimulating alpha-adrenergic receptors, which lift the eyelid muscles, improving the eyelid position and allowing more light into the eye.
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Frequently Asked Questions
How long does it take for Upneeq to work?
Upneeq typically starts working within 5 to 15 minutes after application, and the effects last for several hours.
Can I use Upneeq if I wear contact lenses?
Yes, but you must remove your contact lenses before applying the drops. Wait at least 15 minutes after applying the drops before reinserting your lenses.
How often can I use Upneeq?
Upneeq is intended for once-daily use. Do not exceed the prescribed dose, as using more than recommended can increase the risk of side effects.
Can Upneeq improve my vision?
For patients with ptosis that partially obstructs their vision, Upneeq can improve the field of vision by lifting the eyelid. However, it is not intended to correct refractive vision issues like nearsightedness or farsightedness.
Can I stop using Upneeq if my eyelids improve?
Yes, you can stop using Upneeq at any time, but the effects are temporary. If you stop using the drops, your eyelids will return to their natural position.
Comprehensive Drug Guide
How Does Upneeq Work?
Upneeq works by activating alpha-adrenergic receptors in the muscles that raise the eyelid (the Müller’s muscle). When these receptors are stimulated, the muscle contracts, lifting the upper eyelid. This improves the eyelid position and can enhance vision in patients whose droopy eyelids were partially obstructing their field of vision.
Common Dosages
- Upneeq is available as a 0.1% ophthalmic solution (oxymetazoline hydrochloride). Each single-use vial contains a dose for one application.
Typical Dosing
- The typical dosing for Upneeq is one drop in the affected eye(s) once daily. The effect is usually noticeable within minutes, and the improvement in eyelid position can last several hours.
- Each vial is for single use only. Once opened, the vial should be discarded after use.
Typical Dosing
FDA Approved Indications
- Treatment of acquired blepharoptosis (droopy eyelids) in adults.
Who Shouldn't Take Upneeq?
- Known hypersensitivity to oxymetazoline or any other component of the solution.
Advice From The Pharmacist
- Apply Upneeq exactly as directed by your healthcare provider. One drop should be instilled into the affected eye(s) once a day.
- If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them.
- Avoid touching the tip of the dropper to your eye or any surface to prevent contamination.
- Store Upneeq at room temperature and keep the vials away from excessive heat or light.
Side Effects of Upneeq
Common Side Effects
- Dry eye
- Eye irritation or discomfort
- Redness of the eye
- Blurred vision
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., swelling, rash, difficulty breathing)
- Increased blood pressure (due to systemic absorption of the medication)
- Narrow-angle glaucoma symptoms (pain or redness in the eye, vision changes)
Risks and Warnings of Upneeq
- Cardiovascular Effects: Upneeq is an alpha-adrenergic agonist, and it may cause increases in blood pressure or other cardiovascular side effects, especially in patients with a history of hypertension or heart disease. Monitor blood pressure regularly if you have a history of cardiovascular conditions.
- Narrow-Angle Glaucoma: Upneeq may worsen symptoms in patients with narrow-angle glaucoma. Report any signs of eye pain or vision changes to your healthcare provider immediately.
- Systemic Absorption: While rare, some patients may experience systemic effects such as increased heart rate or elevated blood pressure due to the absorption of the medication through the eye's blood vessels.
Interactions with Upneeq
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): The use of Upneeq with MAOIs (e.g., phenelzine, tranylcypromine) may increase the risk of hypertensive crisis.
- Blood pressure medications: Patients taking medications for hypertension or cardiovascular conditions should be monitored for changes in blood pressure when using Upneeq.
- Other ophthalmic medications: If you are using other eye drops, wait at least 5 minutes between applying different medications.
Alternatives to Upneeq
- Surgical correction (blepharoplasty): For patients with severe or long-term ptosis, eyelid surgery may be a permanent solution.
- Ptosis crutches: Special devices attached to eyeglasses can help support droopy eyelids without the need for medication or surgery.
- Non-surgical lifting devices: Some patients may opt for non-invasive treatments such as Botox to lift the eyelids temporarily.
