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Typhim VI
Typhim VI is a vaccine used to prevent typhoid fever, an infection caused by the bacterium Salmonella typhi. The vaccine contains inactivated (non-living) Vi capsular polysaccharide from S. typhi and helps the body develop immunity against the bacteria without causing disease. Typhim VI is recommended for individuals traveling to regions where typhoid fever is common or for people who may be at increased risk of exposure to the bacteria.
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Frequently Asked Questions
How long does Typhim VI protect against typhoid fever?
Typhim VI provides protection for at least 2 years. If you continue to be at risk of exposure, you should receive a booster dose every 2 years.
Can I get typhoid fever after receiving the vaccine?
While the vaccine is highly effective, it does not provide 100% protection. It is still important to follow safe food and water practices in areas where typhoid fever is common.
Is Typhim VI safe for children?
Yes, Typhim VI is approved for use in children 2 years and older.
What should I do if I miss getting vaccinated before traveling?
It’s recommended to receive the vaccine at least 2 weeks before travel. If you miss this window, consult with a healthcare provider for advice on your specific situation.
Can I get vaccinated while pregnant?
Typhim VI is generally considered safe during pregnancy, but it's important to discuss your risks and benefits with your healthcare provider before receiving the vaccine.
Comprehensive Drug Guide
How Does Typhim VI Work?
Typhim VI works by introducing a small amount of inactivated Vi capsular polysaccharide from Salmonella typhi into the body, stimulating the immune system to produce antibodies. These antibodies help the body recognize and fight the bacteria if exposed in the future. The vaccine does not cause typhoid fever and provides immunity against the disease.
Common Dosages
- Typhim VI is administered as a single-dose injection of 0.5 mL into the deltoid muscle (upper arm) for adults and children over 2 years of age.
Typical Dosing
- One dose of Typhim VI provides protection against typhoid fever for at least 2 years.
- Revaccination is recommended every 2 years for individuals who remain at risk of exposure, such as travelers to endemic areas.
Typical Dosing
FDA Approved Indications
- Prevention of typhoid fever in individuals aged 2 years and older who are at risk of exposure to Salmonella typhi.
Who Shouldn't Take Typhim VI?
- Known allergic reactions to any component of the vaccine.
- Acute febrile illness (fever) or any severe illness, as vaccination should be postponed until recovery.
Advice From The Pharmacist
- Get vaccinated at least 2 weeks before travel to a typhoid-endemic area to allow time for immunity to develop.
- The vaccine provides protection against Salmonella typhi but does not protect against Salmonella paratyphi, which can cause a similar illness.
- Practice good hygiene, such as drinking safe water and eating properly cooked food, even after vaccination, as no vaccine is 100% effective.
- If you experience side effects, such as soreness at the injection site, fever, or headache, these are typically mild and resolve within a few days.
Side Effects of Typhim VI
Common Side Effects
- Pain, redness, or swelling at the injection site
- Mild fever
- Headache
- Fatigue
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis) characterized by rash, swelling, or difficulty breathing.
Risks and Warnings of Typhim VI
- Allergic Reactions: As with any vaccine, there is a small risk of severe allergic reactions (anaphylaxis). If signs of a serious allergic reaction occur, seek emergency medical attention immediately.
- Partial Protection: The vaccine is not 100% effective, and travelers should still follow precautions such as drinking clean water and avoiding risky foods.
Interactions with Typhim VI
Common Drug Interactions
- Immunosuppressive Medications: People taking immunosuppressive drugs, such as corticosteroids or chemotherapy, may have a reduced immune response to the vaccine. Consult your healthcare provider before vaccination.
- Other Vaccines: Typhim VI can be given at the same time as other vaccines, but at different injection sites.
Alternatives to Typhim VI
- Vivotif: An oral typhoid vaccine containing live attenuated Salmonella typhi. It is administered as a series of four capsules over seven days.
- Good hygiene practices: Even with vaccination, avoiding unsafe water, street food, and uncooked foods is essential to preventing typhoid fever.
