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Tuxarin ER
Tuxarin ER is a prescription medication used to treat symptoms related to cough and upper respiratory congestion. It contains two active ingredients: codeine phosphate, an opioid cough suppressant, and chlorpheniramine maleate, an antihistamine. Codeine helps reduce the urge to cough by acting on the brain's cough center, while chlorpheniramine relieves symptoms such as runny nose, sneezing, and itching by blocking histamine, a chemical released during allergic reactions.
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Frequently Asked Questions
How long can I take Tuxarin ER?
Tuxarin ER is intended for short-term use only. Prolonged use increases the risk of dependency and other serious side effects. Consult your healthcare provider if symptoms persist.
Can I drink alcohol while taking Tuxarin ER?
No, you should avoid alcohol while taking Tuxarin ER, as it can increase the sedative effects and the risk of respiratory depression, which can be life-threatening.
Can I drive while taking Tuxarin ER?
No, Tuxarin ER can cause significant drowsiness and impair your ability to drive or operate heavy machinery. Avoid such activities until you know how the medication affects you.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. However, if it’s close to the time for your next dose, skip the missed dose. Do not double up on doses to make up for the missed one.
Is Tuxarin ER safe for children?
Tuxarin ER is not recommended for children under 18 years of age due to the risk of serious side effects, including life-threatening respiratory depression.
Comprehensive Drug Guide
How Does Tuxarin ER Work?
- Codeine: Acts on the central nervous system to suppress the cough reflex by reducing the activity in the brain's cough center.
- Chlorpheniramine: Blocks histamine H1 receptors to reduce symptoms of allergies and respiratory discomfort, such as sneezing, runny nose, and watery eyes.
Common Dosages
- Codeine Phosphate: 54.3 mg per extended-release tablet.
- Chlorpheniramine Maleate: 8 mg per extended-release tablet.
Typical Dosing
- The usual adult dose is one tablet every 12 hours, not to exceed two tablets in 24 hours.
- Tuxarin ER is intended for short-term use only. Extended use of codeine-containing medications can lead to dependence, tolerance, and misuse.
Typical Dosing
FDA Approved Indications
- Temporary relief of cough and upper respiratory symptoms due to allergies or the common cold.
Who Shouldn't Take Tuxarin ER?
- Known hypersensitivity to codeine, chlorpheniramine, or any other component of the medication.
- Respiratory depression (severe breathing problems).
- Severe asthma or chronic obstructive pulmonary disease (COPD).
- Children younger than 18 years of age after tonsillectomy or adenoidectomy.
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping them.
Advice From The Pharmacist
- Take Tuxarin ER exactly as prescribed, and do not exceed the recommended dose due to the risk of serious side effects, including respiratory depression.
- Swallow the tablet whole—do not crush or chew, as this can release all the medication at once and increase the risk of side effects.
- Avoid alcohol while taking Tuxarin ER, as it can increase the sedative effects and the risk of dangerous breathing problems.
- Store the medication in a secure place to prevent misuse or abuse, especially if there are children or others in the household.
Side Effects of Tuxarin ER
Common Side Effects
- Drowsiness or dizziness
- Constipation
- Dry mouth
- Nausea or vomiting
- Blurred vision
Uncommon/Severe Side Effects
- Respiratory depression (slow or shallow breathing)
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Addiction or misuse due to the opioid content
- Seizures
Risks and Warnings of Tuxarin ER
- Respiratory Depression: Codeine can cause severe respiratory depression, especially in higher doses or in individuals with compromised lung function. Patients should be monitored closely for signs of slowed or shallow breathing.
- Addiction and Misuse: Due to the opioid component, there is a high risk of misuse, abuse, and addiction with Tuxarin ER. Use the medication only as prescribed and for the shortest duration possible.
- Sedation: Both codeine and chlorpheniramine can cause significant drowsiness. Avoid driving or operating heavy machinery until you know how the medication affects you.
- Pediatric Use: Codeine-containing products like Tuxarin ER are contraindicated in children under 18 years old after certain surgeries and should be used with caution in all children due to the risk of severe breathing problems.
Interactions with Tuxarin ER
Common Drug Interactions
- Alcohol: Combining Tuxarin ER with alcohol increases the risk of respiratory depression and sedation.
- CNS depressants: Taking Tuxarin ER with other central nervous system depressants, such as benzodiazepines or sedatives, can increase the risk of drowsiness, respiratory depression, and overdose.
- Monoamine oxidase inhibitors (MAOIs): Avoid using Tuxarin ER with MAOIs, as dangerous interactions can occur.
Alternatives to Tuxarin ER
- Benzonatate (Tessalon): A non-opioid cough suppressant that numbs the airways and reduces coughing without the risk of addiction.
- Dextromethorphan (Delsym): An over-the-counter cough suppressant with no risk of addiction, commonly used for temporary relief of cough.
- Promethazine with Codeine: A similar prescription combination used for cough and cold symptoms, but with promethazine as the antihistamine instead of chlorpheniramine.
