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Tri-Lo-Mili
Tri-Lo-Mili is a combination oral contraceptive that contains two hormones: norgestimate (a progestin) and ethinyl estradiol (an estrogen). It is primarily used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining, making it difficult for sperm to reach the egg or for a fertilized egg to implant. Tri-Lo-Mili may also help regulate menstrual cycles, reduce menstrual pain, and treat moderate acne in women who also seek contraception.
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Frequently Asked Questions
How long does it take for Tri-Lo-Mili to become effective?
If you start taking Tri-Lo-Mili on the first day of your period, it is effective immediately. If you start on any other day, use backup contraception for the first 7 days.
Can Tri-Lo-Mili help with acne?
Yes, Tri-Lo-Mili is FDA-approved for the treatment of moderate acne in women aged 15 years or older who seek contraception.
What should I do if I miss a pill?
If you miss one pill, take it as soon as you remember, then continue with your regular schedule. If you miss two or more pills, consult the package insert instructions, and use backup contraception (e.g., condoms) for at least 7 days.
Can I take Tri-Lo-Mili if I smoke?
Smoking while taking Tri-Lo-Mili increases the risk of serious cardiovascular events, especially in women over 35. It is strongly recommended to quit smoking while using this medication.
Can Tri-Lo-Mili cause weight gain?
Some women may experience weight gain due to fluid retention or changes in appetite. Maintaining a healthy diet and regular exercise may help manage this side effect.
Comprehensive Drug Guide
How Does Tri-Lo-Mili Work?
- Inhibiting ovulation: Preventing the release of an egg from the ovary.
- Thickening cervical mucus: Making it more difficult for sperm to reach the uterus.
- Altering the uterine lining: Making it less suitable for a fertilized egg to implant.
Common Dosages
- 21 active tablets with varying hormone doses:
- Days 1–7: 0.18 mg norgestimate / 0.025 mg ethinyl estradiol
- Days 8–14: 0.215 mg norgestimate / 0.025 mg ethinyl estradiol
- Days 15–21: 0.25 mg norgestimate / 0.025 mg ethinyl estradiol
- 7 placebo tablets (inactive).
Typical Dosing
- Take one tablet daily at the same time each day, starting on the first day of your period or the first Sunday after your period begins.
- Continue taking one tablet daily for 28 days, including the 7 placebo tablets.
- Use backup contraception (e.g., condoms) for the first 7 days if starting on any day other than the first day of your period.
Typical Dosing
Who Shouldn't Take Tri-Lo-Mili?
- A history of blood clots, deep vein thrombosis (DVT), or pulmonary embolism.
- A history of stroke or heart attack.
- Uncontrolled hypertension.
- Certain types of cancers (breast, uterine, or liver).
- Liver disease.
- Known hypersensitivity to norgestimate, ethinyl estradiol, or any of the other components.
- Smoking in women over 35 due to an increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Tri-Lo-Mili at the same time every day to ensure maximum effectiveness. Setting an alarm or using a reminder can help with consistency.
- If you miss a pill, refer to the instructions provided in the package insert and use backup contraception if necessary.
- Tri-Lo-Mili does not protect against sexually transmitted infections (STIs). Use condoms to protect yourself from STIs.
- Contact your healthcare provider if you experience severe leg pain, chest pain, or shortness of breath, as these may be signs of a serious blood clot.
Side Effects of Tri-Lo-Mili
Common Side Effects
- Nausea
- Headache
- Breast tenderness
- Weight gain
- Mood changes
- Breakthrough bleeding or spotting
Uncommon/Severe Side Effects
- Blood clots
- Stroke or heart attack
- Liver problems
- Severe migraine headaches
Risks and Warnings of Tri-Lo-Mili
- Blood Clots: Women who smoke and are over the age of 35 have an increased risk of developing blood clots, stroke, or heart attack while taking Tri-Lo-Mili. It is strongly recommended to quit smoking while using this medication.
- Cardiovascular Events: Women with a history of hypertension, diabetes, or high cholesterol may have a higher risk of cardiovascular problems while taking combination oral contraceptives. Consult your doctor to discuss your specific risk factors.
- Liver Tumors: Long-term use of oral contraceptives may increase the risk of benign liver tumors. Seek medical attention if you experience severe abdominal pain or yellowing of the skin or eyes.
- Vision Problems: Tri-Lo-Mili may increase the risk of retinal vein thrombosis. Contact your healthcare provider if you experience sudden changes in vision.
Interactions with Tri-Lo-Mili
Common Drug Interactions
- Antibiotics: Certain antibiotics, such as rifampin, can reduce the effectiveness of Tri-Lo-Mili. Use a backup method of contraception while on these medications.
- Anticonvulsants: Medications like phenytoin or carbamazepine may decrease the effectiveness of Tri-Lo-Mili.
- St. John's Wort: This herbal supplement can reduce the effectiveness of Tri-Lo-Mili, increasing the risk of pregnancy.
Alternatives to Tri-Lo-Mili
- Ortho Tri-Cyclen Lo: Another triphasic oral contraceptive with varying hormone levels.
- Lo Loestrin Fe: A low-dose contraceptive option.
- NuvaRing: A vaginal ring that releases hormones to prevent pregnancy.
- Depo-Provera: A contraceptive injection that is given every three months.
