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Tri-Lo-Marzia
Tri-Lo-Marzia is a combination oral contraceptive that contains two hormones: norgestimate (a progestin) and ethinyl estradiol (an estrogen). It is primarily used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and changing the uterine lining, making it difficult for sperm to reach the uterus and for a fertilized egg to implant. Tri-Lo-Marzia is also used for treating acne in women at least 15 years old who seek birth control.
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Frequently Asked Questions
How long does it take for Tri-Lo-Marzia to become effective?
If you start taking Tri-Lo-Marzia on the first day of your period, it becomes effective immediately. If you start on any other day, use backup contraception for the first 7 days.
Can Tri-Lo-Marzia help with acne?
Yes, Tri-Lo-Marzia is FDA-approved for treating moderate acne in women who also want contraception and are at least 15 years old.
What should I do if I miss a pill?
If you miss one pill, take it as soon as you remember and continue with your regular schedule. If you miss two or more pills, consult the package instructions and use backup contraception for 7 days.
Can I take Tri-Lo-Marzia if I smoke?
Smoking while taking Tri-Lo-Marzia increases the risk of serious cardiovascular events, especially in women over 35. It is strongly recommended that you quit smoking while taking this medication.
Can Tri-Lo-Marzia cause weight gain?
Some women may experience weight gain due to fluid retention or changes in appetite while taking Tri-Lo-Marzia. Maintaining a healthy diet and exercise can help manage weight.
Comprehensive Drug Guide
How Does Tri-Lo-Marzia Work?
- Preventing ovulation: It stops the release of an egg from the ovary.
- Thickening cervical mucus: It makes it more difficult for sperm to reach the uterus.
- Altering the uterine lining: It reduces the likelihood of a fertilized egg implanting in the uterus.
Common Dosages
- 21 active pills with varying hormone levels:
- Days 1–7: 0.18 mg norgestimate / 0.025 mg ethinyl estradiol
- Days 8–14: 0.215 mg norgestimate / 0.025 mg ethinyl estradiol
- Days 15–21: 0.25 mg norgestimate / 0.025 mg ethinyl estradiol
- 7 placebo pills taken during the last week.
Typical Dosing
- Take one tablet daily at the same time each day, starting on the first day of your period or the first Sunday after your period begins.
- Continue taking one pill daily for 28 days, including the 7 placebo pills.
- Use backup contraception (e.g., condoms) for the first 7 days if starting on any day other than the first day of your period.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy.
- Treatment of moderate acne in women aged 15 or older who seek contraception.
Who Shouldn't Take Tri-Lo-Marzia?
- A history of blood clots, deep vein thrombosis (DVT), or pulmonary embolism.
- A history of stroke or heart attack.
- Uncontrolled high blood pressure.
- Certain cancers (breast, uterine, or liver cancer).
- Liver disease.
- Known hypersensitivity to norgestimate, ethinyl estradiol, or other ingredients.
- Smoking and age over 35, as this increases the risk of cardiovascular events.
Advice From The Pharmacist
- Take Tri-Lo-Marzia at the same time each day to ensure its effectiveness. Setting an alarm may help with daily reminders.
- If you miss a pill, refer to the package instructions and use backup contraception (e.g., condoms) if necessary.
- Tri-Lo-Marzia does not protect against sexually transmitted infections (STIs). Use condoms to prevent STIs.
- Contact your healthcare provider if you experience unusual symptoms, such as severe leg pain, chest pain, or shortness of breath, which may indicate a serious blood clot.
Side Effects of Tri-Lo-Marzia
Common Side Effects
- Nausea
- Headaches
- Breast tenderness
- Weight gain
- Mood changes
- Spotting or breakthrough bleeding between periods
Uncommon/Severe Side Effects
- Blood clots
- Stroke or heart attack
- Liver problems
- Severe migraine headaches
Risks and Warnings of Tri-Lo-Marzia
- Blood Clots: Women over 35 who smoke are at higher risk of developing blood clots, heart attack, or stroke while taking combination oral contraceptives like Tri-Lo-Marzia. Quitting smoking is strongly recommended.
- Cardiovascular Events: Women with a history of hypertension, diabetes, or high cholesterol have an elevated risk of heart problems. Discuss risks with your doctor.
- Liver Tumors: Rarely, oral contraceptives can lead to benign liver tumors. Seek immediate medical attention if you experience yellowing of the skin or severe abdominal pain.
- Vision Problems: If you experience sudden changes in vision or retinal vein thrombosis, contact your healthcare provider immediately.
Interactions with Tri-Lo-Marzia
Common Drug Interactions
- Antibiotics: Some antibiotics, like rifampin, can decrease the effectiveness of Tri-Lo-Marzia. Use a backup method of contraception.
- Anticonvulsants: Medications such as carbamazepine or phenytoin may reduce the effectiveness of hormonal birth control.
- St. John's Wort: This herbal supplement can reduce the effectiveness of Tri-Lo-Marzia, increasing the risk of pregnancy.
Alternatives to Tri-Lo-Marzia
- Ortho Tri-Cyclen Lo: A triphasic birth control option with different hormone levels.
- Lo Loestrin Fe: A low-dose birth control pill option.
- Depo-Provera: A contraceptive injection given every three months.
- NuvaRing: A vaginal ring that releases hormones to prevent pregnancy.
