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Tri-Linyah

Tri-Linyah is a combination oral contraceptive that contains two hormones: norgestimate (a progestin) and ethinyl estradiol (an estrogen). It is primarily used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining, making it harder for sperm to reach the egg or for a fertilized egg to implant. Tri-Linyah may also be prescribed for the treatment of acne in women seeking contraception.



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Frequently Asked Questions

How long does it take for Tri-Linyah to become effective?
Open FAQClose FAQ

If you start taking Tri-Linyah on the first day of your period, it becomes effective immediately. If you start on any other day, use backup contraception for the first 7 days.

Can Tri-Linyah help with acne?
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Yes, Tri-Linyah is FDA-approved to treat moderate acne in women who are seeking contraception.

What should I do if I miss a pill?
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If you miss one pill, take it as soon as you remember and continue with your regular schedule. If you miss two or more pills, refer to the package instructions and use backup contraception for 7 days.

Can I take Tri-Linyah if I smoke?
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Smoking while taking Tri-Linyah increases the risk of serious cardiovascular events, especially in women over 35. It is strongly recommended to quit smoking while using this medication.

Can Tri-Linyah cause weight gain?
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Some women may experience weight gain due to water retention or changes in appetite while taking Tri-Linyah. Maintaining a healthy diet and exercise routine can help manage any weight changes.

Comprehensive Drug Guide

How Does Tri-Linyah Work?

  • Inhibiting ovulation: Preventing the release of an egg from the ovaries.
  • Thickening cervical mucus: Making it more difficult for sperm to enter the uterus.
  • Altering the uterine lining: Making it less suitable for a fertilized egg to implant.


Common Dosages

  • 21 active tablets with varying hormone levels:
  • Days 1–7: 0.18 mg norgestimate / 0.025 mg ethinyl estradiol
  • Days 8–14: 0.215 mg norgestimate / 0.025 mg ethinyl estradiol
  • Days 15–21: 0.25 mg norgestimate / 0.025 mg ethinyl estradiol
  • 7 placebo (inactive) tablets for the last week of the cycle.

Typical Dosing

  • Take one tablet daily, at the same time every day. Start on the first day of your period or the first Sunday after your period begins.
  • Continue taking one pill each day for 28 days, including the 7 placebo pills.
  • Use backup contraception (e.g., condoms) for the first 7 days if starting on any day other than the first day of your period.


Typical Dosing

FDA Approved Indications

  • Prevention of pregnancy.
  • Treatment of moderate acne in women aged 15 or older who are seeking contraception.


Who Shouldn't Take Tri-Linyah?

  • A history of blood clots, deep vein thrombosis (DVT), or pulmonary embolism.
  • A history of stroke or heart attack.
  • Uncontrolled hypertension.
  • Breast, uterine, or liver cancer.
  • Liver disease.
  • Known hypersensitivity to norgestimate, ethinyl estradiol, or any other ingredients.
  • Smoking and age over 35, due to the increased risk of cardiovascular events.


Advice From The Pharmacist

  • Take Tri-Linyah at the same time every day for maximum effectiveness. Setting an alarm or using a reminder app can help with daily consistency.
  • If you miss a pill, follow the package insert instructions and use backup contraception (such as condoms) if necessary.
  • Tri-Linyah does not protect against sexually transmitted infections (STIs). Use condoms to protect against STIs.
  • Contact your healthcare provider immediately if you experience symptoms such as severe leg pain, chest pain, or shortness of breath, as these could be signs of a serious blood clot.


Side Effects of Tri-Linyah

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Weight gain
  • Mood changes
  • Breakthrough bleeding or spotting


Uncommon/Severe Side Effects

  • Blood clots
  • Stroke or heart attack
  • Liver problems
  • Severe migraine headaches


Risks and Warnings of Tri-Linyah

  • Blood Clots: Women over 35 who smoke have an increased risk of developing blood clots, heart attack, or stroke while taking Tri-Linyah. It is strongly recommended to quit smoking while using this medication.
  • Cardiovascular Events: Women with a history of hypertension, diabetes, or high cholesterol are at higher risk for cardiovascular issues while using combination oral contraceptives. Discuss your risk factors with your doctor.
  • Liver Tumors: Rarely, benign liver tumors can occur with long-term use of hormonal contraceptives. Seek medical attention if you notice severe abdominal pain, yellowing of the skin or eyes, or dark urine.
  • Vision Problems: Tri-Linyah may increase the risk of retinal vein thrombosis or other vision problems. Contact your doctor if you experience any changes in vision

Interactions with Tri-Linyah

Common Drug Interactions

  • Antibiotics: Some antibiotics, like rifampin, may reduce the effectiveness of Tri-Linyah. Use a backup method of contraception while on antibiotics.
  • Anticonvulsants: Medications such as carbamazepine or phenytoin may lower the effectiveness of hormonal contraceptives.
  • St. John's Wort: This herbal supplement can decrease the effectiveness of Tri-Linyah, increasing the risk of pregnancy.


Alternatives to Tri-Linyah

  • Ortho Tri-Cyclen Lo: A similar triphasic birth control pill with varying hormone levels.
  • Lo Loestrin Fe: A lower-dose oral contraceptive option.
  • Depo-Provera: An injectable contraceptive administered every three months.
  • NuvaRing: A vaginal ring that releases hormones to prevent pregnancy.