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Tri-Legest Fe
Tri-Legest Fe is a combination oral contraceptive that contains norethindrone acetate (a progestin) and ethinyl estradiol (an estrogen). It is used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining. The ferrous fumarate in the inactive pills serves as an iron supplement to help replenish iron stores during menstruation but does not play a role in contraception.
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Frequently Asked Questions
How long does it take for Tri-Legest Fe to become effective?
If you start taking Tri-Legest Fe on the first day of your period, it is effective immediately. If you start on any other day, use backup contraception for the first 7 days.
Can Tri-Legest Fe help with acne?
While Tri-Legest Fe is not specifically approved for treating acne, many combination oral contraceptives, including this one, may improve acne in women who are also seeking contraception.
What should I do if I miss a pill?
If you miss one pill, take it as soon as you remember and continue with your regular schedule. If you miss two or more pills, follow the package insert instructions and use backup contraception for 7 days.
Can I take Tri-Legest Fe if I smoke?
Smoking while taking Tri-Legest Fe increases the risk of serious cardiovascular events, especially in women over 35. It is strongly recommended to quit smoking if using this medication.
Does Tri-Legest Fe cause weight gain?
Some women may experience weight gain due to fluid retention or changes in appetite while taking Tri-Legest Fe. Maintaining a healthy diet and exercise routine can help manage these changes.
Comprehensive Drug Guide
How Does Tri-Legest Fe Work?
- Inhibiting ovulation: Prevents the release of an egg from the ovary.
- Thickening cervical mucus: Makes it harder for sperm to reach the egg.
- Altering the uterine lining: Reduces the likelihood of a fertilized egg implanting in the uterus.
Common Dosages
- 21 active tablets with varying hormone levels:
- Days 1–7: 0.5 mg norethindrone acetate / 0.035 mg ethinyl estradiol
- Days 8–14: 1 mg norethindrone acetate / 0.035 mg ethinyl estradiol
- Days 15–21: 1.5 mg norethindrone acetate / 0.035 mg ethinyl estradiol
- 7 tablets containing 75 mg ferrous fumarate (inactive iron pills).
Typical Dosing
- Take one tablet daily at the same time each day, starting either on the first day of your period or the first Sunday after your period begins.
- Continue taking one tablet daily for 28 days, including the 7 iron tablets.
- Use backup contraception (such as condoms) for the first 7 days if starting on any day other than the first day of your period.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy.
- It may also help regulate menstrual cycles and reduce menstrual bleeding and pain.
Who Shouldn't Take Tri-Legest Fe?
- A history of blood clots, deep vein thrombosis (DVT), or pulmonary embolism.
- A history of stroke or heart attack.
- Uncontrolled hypertension.
- Certain cancers (breast, uterine, or liver cancer).
- Liver disease.
- Known hypersensitivity to norethindrone, ethinyl estradiol, or any components.
- Smoking in women over 35 due to an increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Tri-Legest Fe at the same time every day for maximum effectiveness. Using a reminder or setting an alarm may help maintain consistency.
- If you miss a pill, follow the instructions in the package insert and use backup contraception if necessary.
- Tri-Legest Fe does not protect against sexually transmitted infections (STIs). Use condoms to reduce the risk of STIs.
- Notify your healthcare provider if you experience symptoms such as severe leg pain, shortness of breath, or chest pain, which could be signs of a serious blood clot.
Side Effects of Tri-Legest Fe
Common Side Effects
- Nausea
- Headache
- Breast tenderness
- Weight gain
- Mood changes
- Spotting or breakthrough bleeding
Uncommon/Severe Side Effects
- Blood clots
- Stroke or heart attack
- Liver problems
- Severe migraine headaches
Risks and Warnings of Tri-Legest Fe
- Blood Clots: Women over 35 who smoke have an increased risk of developing blood clots, heart attack, or stroke while taking Tri-Legest Fe. It is strongly recommended to quit smoking if using this medication.
- Cardiovascular Events: Women with hypertension, diabetes, or high cholesterol have an increased risk of cardiovascular complications. Discuss these risks with your doctor before starting Tri-Legest Fe.
- Liver Tumors: Long-term use of hormonal contraceptives has been associated with the development of benign liver tumors. Seek medical attention if you experience severe abdominal pain or yellowing of the skin.
- Vision Problems: Rarely, Tri-Legest Fe may cause retinal vein thrombosis. Notify your doctor if you experience any sudden vision changes.
Interactions with Tri-Legest Fe
Common Drug Interactions
- Antibiotics: Some antibiotics, such as rifampin, may reduce the effectiveness of Tri-Legest Fe. Use a backup method of contraception while on antibiotics.
- Anticonvulsants: Medications like carbamazepine or phenytoin may reduce the effectiveness of hormonal birth control.
- St. John's Wort: This herbal supplement may decrease the effectiveness of Tri-Legest Fe, increasing the risk of pregnancy.
Alternatives to Tri-Legest Fe
- Ortho Tri-Cyclen Lo: A triphasic birth control option with different hormone levels.
- Lo Loestrin Fe: A lower-dose oral contraceptive that also contains iron pills.
- NuvaRing: A vaginal ring that releases hormones to prevent pregnancy.
- Depo-Provera: A contraceptive injection administered every 3 months.
