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Tri-Estarylla
Tri-Estarylla is an oral contraceptive that combines two hormones: norgestimate (a progestin) and ethinyl estradiol (an estrogen). It is used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining, making it harder for sperm to reach the uterus and for a fertilized egg to attach. Tri-Estarylla is also used to treat acne in women who are at least 15 years old and have started menstruating.
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Frequently Asked Questions
What should I do if I miss a pill?
If you miss one pill, take it as soon as you remember. If you miss two or more, follow the instructions in the package insert and use a backup method of contraception for at least 7 days.
Can Tri-Estarylla cause weight gain?
Weight gain is a possible side effect of Tri-Estarylla, though not all women experience this. Maintaining a healthy diet and exercise routine may help manage weight changes.
How long does it take for Tri-Estarylla to start working?
If you start taking Tri-Estarylla on the first day of your period, it becomes effective immediately. If you start on any other day, use a backup method of contraception (e.g., condoms) for the first 7 days.
Can I use Tri-Estarylla to treat acne?
Yes, Tri-Estarylla is approved for the treatment of moderate acne in women aged 15 years or older who also desire contraception.
What should I do if I experience breakthrough bleeding?
Breakthrough bleeding is common during the first few months of using oral contraceptives. If it persists or becomes heavy, consult your healthcare provider.
Comprehensive Drug Guide
How Does Tri-Estarylla Work?
- Inhibiting ovulation: Preventing the release of an egg from the ovary.
- Thickening cervical mucus: Making it more difficult for sperm to enter the uterus.
- Thinning the uterine lining: Reducing the likelihood of a fertilized egg implanting.
Common Dosages
- 7 tablets are placebo pills (inactive), taken during the last week of the cycle.
- The active tablets contain varying doses of norgestimate and ethinyl estradiol in a triphasic format:
- Day 1–7: 0.18 mg norgestimate / 0.035 mg ethinyl estradiol
- Day 8–14: 0.215 mg norgestimate / 0.035 mg ethinyl estradiol
- Day 15–21: 0.25 mg norgestimate / 0.035 mg ethinyl estradiol
Typical Dosing
- Take one tablet daily at the same time each day, starting on the first day of your period or on the first Sunday after your period begins.
- Continue taking one pill daily for 28 days, including the 7 placebo pills.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy (contraception).
- Treatment of moderate acne in women at least 15 years old who are seeking contraception.
Who Shouldn't Take Tri-Estarylla?
- History of blood clots (deep vein thrombosis, pulmonary embolism)
- History of stroke or heart attack
- Severe high blood pressure (uncontrolled hypertension)
- Certain cancers (breast, uterine, or liver cancer)
- Liver disease
- Known hypersensitivity to norgestimate, ethinyl estradiol, or any component of the formulation
- Smoking in women over age 35, due to an increased risk of cardiovascular events
Advice From The Pharmacist
- Take Tri-Estarylla at the same time every day for the best results. Set an alarm or reminder to help maintain consistency.
- If you miss a pill, follow the instructions in the package insert for how to proceed. Missing more than one pill increases the risk of pregnancy.
- Use a backup method of contraception (e.g., condoms) if you miss pills, especially in the first week of your cycle.
- This medication does not protect against sexually transmitted infections (STIs). Use condoms to prevent STIs.
- If you experience unusual symptoms like severe leg pain, chest pain, or shortness of breath, seek medical attention immediately, as these may be signs of a serious blood clot.
Side Effects of Tri-Estarylla
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Weight gain
- Mood changes
- Spotting or breakthrough bleeding
Uncommon/Severe Side Effects
- Blood clots (in the legs or lungs)
- Heart attack or stroke
- Liver problems
- Severe migraines
Risks and Warnings of Tri-Estarylla
- Blood Clots: Combination oral contraceptives increase the risk of blood clots, especially in smokers over 35 years old. Discontinue use if you experience symptoms such as swelling, pain in the leg, shortness of breath, or chest pain.
- Cardiovascular Events: Women who smoke and use Tri-Estarylla, especially those over age 35, have a higher risk of cardiovascular events like heart attacks or strokes. It's advised to quit smoking while taking this medication.
- Liver Tumors: Rarely, oral contraceptives like Tri-Estarylla can cause benign liver tumors. If you experience severe stomach pain or yellowing of the skin or eyes, contact your healthcare provider.
Interactions with Tri-Estarylla
Common Drug Interactions
- Antibiotics: Some antibiotics, such as rifampin, can reduce the effectiveness of Tri-Estarylla. Use a backup contraceptive method if taking antibiotics.
- Anticonvulsants: Medications like phenytoin or carbamazepine can reduce the effectiveness of hormonal contraceptives.
- St. John's Wort: This herbal supplement can decrease the effectiveness of Tri-Estarylla, increasing the risk of pregnancy.
Alternatives to Tri-Estarylla
- Ortho Tri-Cyclen: Another triphasic combination oral contraceptive containing norgestimate and ethinyl estradiol.
- Lo Loestrin Fe: A low-dose combination birth control pill.
- Depo-Provera: A hormonal contraceptive injection given every three months.
- NuvaRing: A hormonal contraceptive vaginal ring.
