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Trecator
Trecator (ethionamide) is an antibiotic used to treat tuberculosis (TB), particularly drug-resistant forms of TB. It is typically prescribed as part of a combination therapy with other anti-TB medications to ensure effectiveness and reduce the risk of resistance. Trecator works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that causes TB, by interfering with the production of essential proteins the bacteria need to multiply.
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Frequently Asked Questions
How long will I need to take Trecator?
Trecator is usually taken as part of a combination therapy for 6 to 12 months or longer, depending on the severity of the TB infection and how the bacteria respond to treatment.
Can Trecator be taken alone to treat tuberculosis?
No, Trecator must be taken as part of a combination therapy with other TB medications to prevent the development of drug-resistant TB strains.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Is it safe to drink alcohol while taking Trecator?
No, alcohol should be avoided while taking Trecator, as it increases the risk of liver damage and other side effects.
Can Trecator cause nerve damage?
Yes, Trecator can cause peripheral neuropathy (nerve damage). Your doctor may prescribe vitamin B6 (pyridoxine) to help prevent or reduce this side effect. If you experience tingling or numbness, inform your healthcare provider immediately.
Comprehensive Drug Guide
How Does Trecator Work?
Trecator (ethionamide) works by inhibiting the synthesis of mycolic acids, which are essential components of the cell walls of Mycobacterium tuberculosis. Without these building blocks, the bacteria are unable to grow and reproduce, which helps to control the infection and prevent it from spreading.
Common Dosages
- 250 mg tablets
Typical Dosing
- The typical dose for adults is 250 mg to 500 mg once or twice daily, depending on the patient's weight and response to treatment. It is usually part of a multi-drug regimen for TB treatment.
- Dosage may be adjusted based on tolerability, and it should always be taken under the supervision of a healthcare provider.
Typical Dosing
FDA Approved Indications
- The treatment of tuberculosis (TB), particularly in cases of drug-resistant TB, in combination with other anti-TB medications.
Who Shouldn't Take Trecator?
- Known hypersensitivity to ethionamide or any of the components of the formulation.
- Severe liver disease or hepatic dysfunction, as the drug is metabolized by the liver.
Advice From The Pharmacist
- Take Trecator exactly as prescribed by your healthcare provider. It is important to take it as part of a combination regimen to prevent the development of drug-resistant TB.
- Take the tablets with food to minimize stomach upset, as this medication can cause gastrointestinal discomfort.
- Complete the full course of treatment, even if symptoms improve, to avoid the development of resistant strains of TB.
- Regular blood tests may be required to monitor liver function during treatment with Trecator.
Side Effects of Trecator
Common Side Effects
- Nausea
- Vomiting
- Loss of appetite
- Stomach pain
- Diarrhea
Uncommon/Severe Side Effects
- Liver toxicity (yellowing of the skin or eyes, dark urine, severe fatigue)
- Peripheral neuropathy (tingling, numbness, or pain in the hands or feet)
- Severe allergic reactions (rash, difficulty breathing, swelling)
Risks and Warnings of Trecator
- Liver Toxicity: Trecator can cause liver damage, especially in patients with pre-existing liver disease. Regular monitoring of liver function is essential during treatment. Discontinue use and seek medical attention if you experience jaundice (yellowing of the skin or eyes) or other signs of liver problems.
- Peripheral Neuropathy: Patients may develop nerve damage (tingling, pain, or numbness in the hands or feet). Pyridoxine (vitamin B6) is often prescribed alongside Trecator to reduce this risk.
- Gastrointestinal Upset: Nausea and vomiting are common, and taking the medication with food can help reduce these side effects.
Interactions with Trecator
Common Drug Interactions
- Isoniazid: This combination can increase the risk of liver toxicity. Patients should be closely monitored when taking Trecator with other TB medications.
- Alcohol: Alcohol consumption should be avoided during treatment with Trecator, as it can increase the risk of liver damage.
- Antidiabetic medications: Ethionamide may reduce the effectiveness of certain antidiabetic drugs, requiring adjustments to diabetes treatment.
Alternatives to Trecator
- Isoniazid: Another first-line anti-tuberculosis medication.
- Rifampin: A common anti-TB medication used as part of multi-drug regimens for TB.
- Pyrazinamide: Often combined with ethionamide in the treatment of TB.
- Cycloserine: Another antibiotic used in combination therapy for multi-drug resistant TB cases.
