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Terbutaline Sulfate

Terbutaline Sulfate is a beta-2 adrenergic agonist used to treat bronchospasm in patients with asthma, chronic obstructive pulmonary disease (COPD), and other conditions involving reversible airway obstruction. It works by relaxing the muscles in the airways, helping to open them up and make breathing easier. Terbutaline is available as an oral tablet, inhalation solution, and injectable form, though it is primarily used for short-term relief of breathing difficulties.


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Frequently Asked Questions

How quickly does Terbutaline Sulfate work?
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For subcutaneous injection, terbutaline can begin working within 5 to 15 minutes. For oral tablets, it may take up to 30 minutes to start working, and for inhalation, it begins to work within minutes.

Can I use Terbutaline as a rescue inhaler for asthma attacks?
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Terbutaline inhalation is sometimes used for quick relief of asthma symptoms. However, albuterol is more commonly prescribed as a rescue inhaler. Follow your doctor’s recommendations on which medication to use for immediate symptom relief.

What should I do if I miss a dose of oral Terbutaline?
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If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.

Can Terbutaline cause weight gain?
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Terbutaline is not known to cause weight gain. If you experience unexplained weight gain, consult your healthcare provider, as it may indicate another issue, such as fluid retention.

Can Terbutaline be used for long-term asthma management?
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Terbutaline is typically used for short-term relief of bronchospasm. Long-term asthma management often involves the use of inhaled corticosteroids and long-acting bronchodilators. Terbutaline may be used as needed for short-term control but is not usually the main treatment for long-term asthma control.

Comprehensive Drug Guide

How Does Terbutaline Sulfate Work?

Terbutaline works by stimulating beta-2 receptors in the lungs, causing the smooth muscles in the airways to relax. This dilation of the bronchial passages helps to relieve bronchospasms, allowing for easier breathing. This makes it especially effective for treating asthma attacks or other conditions that cause narrowing of the airways.



What is Terbutaline Sulfate Used For?


Common Dosages

  • Oral tablets: 2.5 mg and 5 mg
  • Subcutaneous injection: 1 mg/mL
  • Inhalation solution: Doses may vary

Typical Dosing

  • For bronchospasm (oral): The typical dose is 2.5 mg to 5 mg taken three times daily, with a maximum of 15 mg per day.
  • For bronchospasm (injection): A subcutaneous dose of 0.25 mg is injected every 15 to 30 minutes as needed. The maximum recommended dose is 0.5 mg every 4 hours.
  • For inhalation: Doses depend on the formulation and should be used as directed by a healthcare provider.

Typical Dosing

FDA Approved Indications

  • Bronchospasm associated with asthma, chronic bronchitis, or emphysema.
  • Chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

Off-Label Uses


Who Shouldn't Take Terbutaline Sulfate?

  • Known hypersensitivity to terbutaline or any of its components
  • Pre-existing cardiac arrhythmias or severe hypertension
  • Preterm labor: Terbutaline has previously been used off-label to suppress preterm labor, but this use is no longer recommended due to risks to the mother and baby.

Advice From The Pharmacist

  • Take the medication exactly as prescribed to avoid the risk of side effects such as rapid heartbeat, dizziness, or tremors.
  • Inhalation forms should be used at the first sign of bronchospasm. Ensure proper technique when using inhalers or nebulizers to maximize the medication’s effectiveness.
  • Oral forms of terbutaline may take longer to work compared to inhaled forms, so they are typically used for maintenance treatment rather than immediate relief.
  • Monitor for signs of overdose, such as chest pain, rapid heart rate, tremors, or feeling faint. Seek immediate medical attention if any of these symptoms occur.
  • Avoid using other bronchodilators (e.g., albuterol) unless directed by your doctor, as this could increase the risk of side effects like rapid heart rate or shakiness.

Side Effects of Terbutaline Sulfate

Common Side Effects

  • Tremors or shaking
  • Nervousness
  • Dizziness
  • Headache
  • Rapid heartbeat (tachycardia)
  • Nausea


Uncommon/Severe Side Effects

  • Chest pain
  • Palpitations or irregular heart rhythms
  • High blood pressure
  • Severe allergic reactions, including rash, swelling, or difficulty breathing

Risks and Warnings of Terbutaline Sulfate

  • Cardiovascular Effects: Terbutaline can cause an increase in heart rate and blood pressure. Patients with heart conditions should use the drug with caution.
  • Use in Pregnancy: Terbutaline should not be used to manage preterm labor, as it can cause serious maternal and fetal side effects, including increased heart rate, elevated blood pressure, and risk of heart attack in the mother.
  • Use in Diabetes: Terbutaline may increase blood glucose levels, which should be monitored closely in diabetic patients.

Interactions with Terbutaline Sulfate

Common Drug Interactions

  • Beta-blockers: Medications like propranolol may block the effects of terbutaline, reducing its effectiveness in treating bronchospasm.
  • Other bronchodilators: Using terbutaline with other bronchodilators can increase the risk of side effects such as rapid heart rate or tremors.
  • Tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs): These medications can increase the cardiovascular effects of terbutaline, such as an increased risk of hypertension or tachycardia.

Alternatives to Terbutaline Sulfate

  • Albuterol (Proventil, Ventolin): A short-acting beta-2 agonist commonly used to treat asthma and COPD-related bronchospasm.
  • Salmeterol (Serevent): A long-acting beta-2 agonist used for maintenance treatment of asthma and COPD.
  • Ipratropium (Atrovent): A bronchodilator used for bronchospasm associated with COPD, often in combination with albuterol.
  • Formoterol: Another long-acting beta-2 agonist, used primarily for maintenance treatment in asthma and COPD.