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Telmisartan-amLODIPine
Telmisartan-amLODIPine is a combination medication used to treat high blood pressure (hypertension). It contains telmisartan, an angiotensin II receptor blocker (ARB), and amlodipine, a calcium channel blocker (CCB). Telmisartan helps relax blood vessels by blocking the action of angiotensin II, while amlodipine works by preventing calcium from entering the cells of the heart and blood vessel walls, resulting in further relaxation and lowered blood pressure. This combination helps manage hypertension and reduces the risk of heart attacks, strokes, and kidney problems.
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Frequently Asked Questions
How long does it take for Telmisartan-amLODIPine to start working?
Telmisartan-amLODIPine may start to lower blood pressure within a few hours, but it may take 2 to 4 weeks for the full effects to be seen.
Can I stop taking Telmisartan-amLODIPine if my blood pressure is controlled?
No, you should not stop taking Telmisartan-amLODIPine without consulting your healthcare provider. Stopping suddenly can cause a rapid increase in blood pressure.
What should I do if I miss a dose of Telmisartan-amLODIPine?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.
Can I drink alcohol while taking Telmisartan-amLODIPine?
Alcohol can increase the blood pressure-lowering effects of Telmisartan-amLODIPine, leading to dizziness or fainting. It is best to limit alcohol consumption or avoid it.
Is Telmisartan-amLODIPine safe for long-term use?
Yes, Telmisartan-amLODIPine is considered safe for long-term use when monitored by a healthcare provider. Regular blood pressure and kidney function checks are recommended to ensure continued safety and efficacy.
Comprehensive Drug Guide
How Does Telmisartan-amLODIPine Work?
- Telmisartan blocks the effects of angiotensin II, a hormone that causes blood vessels to tighten. By preventing this action, telmisartan helps relax and widen blood vessels, lowering blood pressure.
- Amlodipine inhibits calcium ions from entering the smooth muscle cells of the heart and arteries. This reduces the contraction of blood vessels, further helping to lower blood pressure and reduce the workload on the heart.
Common Dosages
- Telmisartan 40 mg / Amlodipine 5 mg
- Telmisartan 40 mg / Amlodipine 10 mg
- Telmisartan 80 mg / Amlodipine 5 mg
- Telmisartan 80 mg / Amlodipine 10 mg
Typical Dosing
- Adults: One tablet is typically taken once daily, with or without food. The dosage will depend on the patient's blood pressure control and response to the medication.
- Adjustments: Your doctor may adjust the dose as needed to achieve the desired blood pressure control.
Typical Dosing
FDA Approved Indications
- Hypertension: To lower blood pressure in patients who need dual therapy.
- Cardiovascular Risk Reduction: Helps lower the risk of stroke and heart attack in patients with high blood pressure or other cardiovascular risks.
Who Shouldn't Take Telmisartan-amLODIPine?
- Severe hypotension (low blood pressure)
- Severe liver impairment
- Known hypersensitivity to either telmisartan, amlodipine, or other components of the drug
- Pregnancy, especially in the second and third trimesters, due to potential harm to the fetus
Advice From The Pharmacist
- Take Telmisartan-amLODIPine at the same time every day to maintain consistent levels of the medication in your body.
- If you experience dizziness or lightheadedness, especially when starting treatment, avoid standing up too quickly to prevent falls.
- Monitor your blood pressure regularly to ensure the medication is effectively lowering it.
- Do not stop taking the medication suddenly, as this may cause a rapid increase in blood pressure.
- Avoid grapefruit or grapefruit juice, as it may increase the levels of amlodipine in your blood and raise the risk of side effects.
Side Effects of Telmisartan-amLODIPine
Common Side Effects
- Dizziness
- Swelling (edema), particularly in the legs or feet
- Fatigue
- Flushing or redness of the face
- Headache
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling of the face, lips, tongue, or throat)
- Low blood pressure (hypotension)
- Increased angina or worsening of chest pain in patients with pre-existing heart disease
- Kidney problems, particularly in those with pre-existing kidney conditions
Risks and Warnings of Telmisartan-amLODIPine
- Pregnancy Warning: Telmisartan can cause injury or death to an unborn baby, especially in the second and third trimesters. Women who are pregnant or planning to become pregnant should not take Telmisartan-amLODIPine.
- Liver and Kidney Function: Regular monitoring of liver and kidney function may be necessary, especially in patients with pre-existing conditions.
- Hypotension: This medication can cause significant drops in blood pressure, particularly in those who are volume-depleted or on diuretics. Be cautious when standing up or changing positions quickly.
Interactions with Telmisartan-amLODIPine
Common Drug Interactions
- Grapefruit: Avoid grapefruit or grapefruit juice as it can increase amlodipine levels in the blood and raise the risk of side effects.
- Potassium supplements or salt substitutes: Using these with telmisartan may increase the risk of high potassium levels (hyperkalemia).
- Nonsteroidal anti-inflammatory drugs (NSAIDs): These drugs may reduce the blood pressure-lowering effects of Telmisartan-amLODIPine and increase the risk of kidney damage.
- Other blood pressure medications: Combining Telmisartan-amLODIPine with other antihypertensive medications can result in an exaggerated blood pressure-lowering effect, increasing the risk of hypotension.
Alternatives to Telmisartan-amLODIPine
- Losartan-Amlodipine: Another combination of an ARB and calcium channel blocker used to manage hypertension.
- Valsartan-Amlodipine: A similar ARB/CCB combination for hypertension treatment.
- Lisinopril-Amlodipine: A combination of an ACE inhibitor and calcium channel blocker, often used as an alternative for those who cannot tolerate ARBs.
- Amlodipine alone: A calcium channel blocker that can be used for managing hypertension if ARBs are not needed.
