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Suprep Bowel Prep Kit

Suprep Bowel Prep Kit is an oral solution used for bowel cleansing prior to a colonoscopy. It contains sodium sulfate, potassium sulfate, and magnesium sulfate, which work as osmotic laxatives. This combination draws water into the colon, helping to stimulate bowel movements and thoroughly clear the colon of stool to allow a clear view for the colonoscopy procedure.



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Frequently Asked Questions

How long does it take for Suprep to start working?
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Suprep usually begins working within 30 minutes to an hour after taking the first dose, although some patients may not see results for several hours.

Can I eat while taking Suprep?
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No, you should follow a clear liquid diet the day before your colonoscopy and avoid solid foods during the bowel preparation process.

What should I do if I miss a dose of Suprep?
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If you miss a dose, contact your healthcare provider for instructions. It is important to follow the preparation schedule carefully to ensure effective bowel cleansing.

How much water do I need to drink with Suprep?
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You will need to drink 16 ounces of water with each dose of the prep solution, followed by an additional 32 ounces of water over the next hour.

Can I take my regular medications while using Suprep?
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You should inform your healthcare provider about any regular medications you're taking, especially diuretics, blood pressure medications, or NSAIDs, as some medications may need to be adjusted or paused during the bowel preparation process.

Comprehensive Drug Guide

How Does Suprep Bowel Prep Kit Work?

Suprep works by drawing water into the colon through osmosis. This increases the amount of water in the stool, making it softer and easier to pass. The rapid movement of stool through the colon clears out the bowel, which is necessary to obtain clear visualization of the colon during a colonoscopy.



Common Dosages

  • Dose 1: One 6-ounce bottle diluted with water to 16 ounces, followed by drinking an additional 32 ounces of water.
  • Dose 2: Another 6-ounce bottle diluted with water to 16 ounces, followed by an additional 32 ounces of water, taken 10 to 12 hours after the first dose.

Typical Dosing

  • Step 1: Take one 6-ounce bottle diluted with water to 16 ounces. Drink the solution and follow it by drinking 32 ounces of water over the next hour.
  • Step 2: Repeat the process 10 to 12 hours later with the second 6-ounce bottle, followed by 32 ounces of water again.


Typical Dosing

FDA Approved Indications

  • Bowel cleansing prior to a colonoscopy in adults.

Who Shouldn't Take Suprep Bowel Prep Kit?

  • Severe kidney disease or renal impairment.
  • Bowel obstructions or gastrointestinal perforation.
  • Severe dehydration or electrolyte imbalances.
  • Hypersensitivity to any of the components in the solution.

Advice From The Pharmacist

  • Follow the dosing schedule closely to ensure effective bowel cleansing. Make sure you drink the full volume of liquid as instructed.
  • Stay hydrated: You will be losing a lot of fluids due to frequent bowel movements, so it’s important to drink plenty of water to avoid dehydration.
  • Stick to a clear liquid diet: Avoid solid foods the day before the procedure, and follow your healthcare provider's instructions regarding the clear liquid diet.
  • Remain near a bathroom: Suprep causes frequent, urgent bowel movements, so make sure you are near a bathroom after taking each dose.

Side Effects of Suprep Bowel Prep Kit

Common Side Effects

  • Nausea
  • Vomiting
  • Abdominal pain or cramping
  • Bloating
  • Dehydration
  • Headache


Uncommon/Severe Side Effects

  • Electrolyte imbalances (e.g., low sodium, potassium, or magnesium).
  • Severe dehydration, which can cause dizziness, fainting, and low blood pressure.
  • Kidney injury, especially in patients with pre-existing kidney conditions.


Risks and Warnings of Suprep Bowel Prep Kit

  • Dehydration: Suprep causes significant fluid loss through diarrhea, which can lead to dehydration. Drink additional clear liquids during the prep process to avoid this risk.
  • Electrolyte Imbalances: Patients with heart conditions or those on medications like diuretics may be at higher risk of electrolyte imbalances and should be closely monitored.
  • Kidney Injury: Osmotic laxatives like Suprep may cause acute kidney injury, especially in patients with pre-existing kidney problems or those taking medications that affect kidney function.
  • Gastrointestinal Risks: Suprep should not be used in patients with a history of bowel obstructions, Crohn’s disease, or severe colitis due to the risk of worsening symptoms.


Interactions with Suprep Bowel Prep Kit

Common Drug Interactions

  • Diuretics: Combining Suprep with diuretics (e.g., furosemide) can increase the risk of dehydration and electrolyte imbalances.
  • ACE inhibitors and ARBs: Medications like lisinopril or losartan can increase the risk of kidney injury when combined with osmotic laxatives.
  • NSAIDs: Nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen) may increase the risk of kidney injury when used with bowel prep medications.
  • Antacids: Antacids containing magnesium or aluminum should be avoided as they can worsen electrolyte imbalances.


Alternatives to Suprep Bowel Prep Kit

  • GoLYTELY (Polyethylene Glycol 3350): A liquid solution used for bowel cleansing before colonoscopy.
  • MoviPrep: A polyethylene glycol-based solution that is flavored and taken in a two-dose regimen.
  • Clenpiq: A flavored liquid bowel prep solution that can be taken in a smaller volume compared to traditional prep solutions.
  • Sutab: A tablet form of bowel prep that uses osmotic laxatives similar to Suprep.