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Sucraid

Sucraid, the brand name for sacrosidase, is an enzyme replacement therapy used to treat congenital sucrase-isomaltase deficiency (CSID), a rare genetic disorder in which the body lacks the enzymes needed to digest sucrose (table sugar) and starches. Sucraid helps replace the deficient enzyme sucrase, allowing the body to break down sucrose into glucose and fructose, which can then be absorbed by the body. This treatment helps alleviate symptoms such as bloating, gas, diarrhea, and stomach pain that result from undigested sugars.

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Frequently Asked Questions

How quickly does Sucraid start working?
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Sucraid begins working immediately after consumption, as it helps break down sucrose during digestion. Symptoms of sucrose intolerance, such as bloating and diarrhea, should improve within 1 to 2 meals after starting treatment.

Can I mix Sucraid with juice?
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No, Sucraid should not be mixed with acidic beverages like fruit juices (e.g., orange or tomato juice) because the acidity can degrade the enzyme and reduce its effectiveness.

What should I do if I miss a dose of Sucraid?
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If you miss a dose of Sucraid, take it as soon as you remember during the next meal or snack. Do not take extra to make up for the missed dose.

Is Sucraid safe for long-term use?
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Yes, Sucraid is generally considered safe for long-term use in individuals with congenital sucrase-isomaltase deficiency. Regular monitoring and adjustments may be needed, based on dietary changes and symptom management.

Can infants use Sucraid?
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Yes, Sucraid is safe for use in infants and children with congenital sucrase-isomaltase deficiency, with doses adjusted based on weight. Always follow your healthcare provider's dosing instructions.

Comprehensive Drug Guide

How Does Sucraid Work?

Sucraid provides sacrosidase, a yeast-derived enzyme that mimics the activity of sucrase, the enzyme that breaks down sucrose into glucose and fructose. In patients with congenital sucrase-isomaltase deficiency, their bodies cannot digest sucrose properly, leading to gastrointestinal symptoms. By supplying the missing enzyme, Sucraid helps facilitate the digestion and absorption of sucrose, reducing or eliminating the symptoms associated with the disorder.

Common Dosages

  • For patients up to 15 kg (33 lbs): The recommended dose is 1 mL per meal or snack.
  • For patients over 15 kg (33 lbs): The recommended dose is 2 mL per meal or snack.

Each dose should be diluted with water, milk, or infant formula and consumed with the first bite of food.

Typical Dosing

  • For infants and children weighing less than 15 kg: 1 mL per meal or snack, mixed with water, milk, or formula.
  • For children and adults weighing over 15 kg: 2 mL per meal or snack, mixed with water, milk, or formula. Sucraid should be taken at the beginning of each meal or snack. The dose can be divided into two parts: one-half at the start and the other half during the meal.

Typical Dosing

FDA Approved Indications

  • Congenital sucrase-isomaltase deficiency (CSID): An enzyme deficiency that affects the digestion of sucrose and starches.

Who Shouldn't Take Sucraid?

  • Known hypersensitivity to sacrosidase or any component of the formulation.
  • Yeast allergies, as the enzyme is derived from baker's yeast.

Advice From The Pharmacist

  • Take Sucraid with meals or snacks by diluting the dose in water, milk, or formula, and consume it with the first bite of food. Half of the dose should be taken at the start of the meal and the other half during the meal.
  • Do not mix Sucraid with fruit juices (such as orange or tomato juice), as these juices are acidic and may reduce the effectiveness of the enzyme.
  • Refrigerate Sucraid after opening and use it within 4 weeks. Do not freeze the solution.
  • If you experience any unusual symptoms such as hives, rash, or difficulty breathing, stop taking Sucraid and seek medical attention, as these may be signs of an allergic reaction.

Side Effects of Sucraid

Common Side Effects

  • Stomach pain or discomfort
  • Nausea
  • Gas or bloating

Uncommon/Severe Side Effects

  • Allergic reactions: Symptoms such as rash, itching, swelling, dizziness, or difficulty breathing.

Risks and Warnings of Sucraid

  • Allergic reactions: Sucraid is derived from yeast, so individuals with known yeast allergies should avoid using this medication. Signs of an allergic reaction include hives, rash, or difficulty breathing, and require immediate medical attention.
  • Enzyme degradation: Acidic drinks, such as fruit juices, can degrade the enzyme in Sucraid, reducing its effectiveness. Avoid mixing the medication with acidic liquids.

Interactions with Sucraid

Common Drug Interactions

  • Acidic foods or drinks: Avoid mixing Sucraid with acidic foods or drinks (such as fruit juices), as they can reduce the enzyme’s activity and effectiveness.
  • There are no significant drug-drug interactions known with Sucraid, but always inform your healthcare provider of any other medications or supplements you are taking.

Alternatives to Sucraid

  • Dietary management: In some cases, individuals with congenital sucrase-isomaltase deficiency may be managed through strict dietary restrictions, such as eliminating foods high in sucrose.
  • Lactase supplements: For individuals with other enzyme deficiencies (e.g., lactose intolerance), lactase supplements are an alternative but are specific to lactose digestion.