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Steglatro

Steglatro (generic name: ertugliflozin) is an oral medication used to manage blood sugar levels in adults with type 2 diabetes mellitus. It belongs to the class of SGLT2 inhibitors (sodium-glucose co-transporter 2 inhibitors), which work by helping the kidneys remove excess glucose from the bloodstream through urine. Steglatro is used as part of a comprehensive diabetes management plan, which includes diet and exercise, to improve glycemic control.

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Frequently Asked Questions

How long does it take for Steglatro to start lowering my blood sugar?
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Steglatro starts working within hours, but it may take several weeks to see significant improvements in blood sugar levels when used as part of a long-term diabetes management plan.

Can Steglatro help me lose weight?
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Some patients may experience modest weight loss while taking Steglatro, as the medication helps excrete excess glucose, which carries calories out of the body.

Should I stop taking Steglatro if I get a urinary tract infection?
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If you develop symptoms of a urinary tract infection (UTI) such as burning during urination or frequent urges to urinate, contact your healthcare provider. You may need treatment for the UTI, but stopping Steglatro is not always necessary.

Can Steglatro cause low blood sugar?
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Steglatro is less likely to cause low blood sugar on its own, but the risk increases if it is used with insulin or medications that increase insulin production. Regular monitoring of blood sugar is important.

What should I do if I miss a dose of Steglatro?
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If you miss a dose, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

Comprehensive Drug Guide

How Does Steglatro Work?

Steglatro works by inhibiting the SGLT2 protein in the kidneys, which is responsible for reabsorbing glucose back into the bloodstream. By blocking this protein, Steglatro allows excess glucose to be excreted through urine, thereby lowering blood sugar levels in patients with type 2 diabetes.

Common Dosages

  • 5 mg tablets
  • 15 mg tablets

Typical Dosing

  • The typical starting dose is 5 mg once daily, taken in the morning with or without food.

If needed for additional glycemic control, the dose may be increased to 15 mg once daily.

Typical Dosing

FDA Approved Indications

  • Type 2 diabetes mellitus in adults, as part of a comprehensive plan including diet and exercise.

It is not approved for use in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.

Who Shouldn't Take Steglatro?

  • Severe renal impairment, end-stage renal disease, or patients on dialysis.
  • Hypersensitivity to ertugliflozin or any components of the formulation.
  • Diabetic ketoacidosis (Steglatro is not suitable for treating this condition).

Advice From The Pharmacist

  • Take Steglatro once daily, preferably in the morning. You can take it with or without food, but make sure to stay hydrated, as SGLT2 inhibitors can increase the risk of dehydration.
  • It is important to monitor blood sugar levels regularly and report any significant changes to your healthcare provider.
  • Be mindful of any signs of urinary tract infections or genital yeast infections, as these are more common with SGLT2 inhibitors.
  • Maintain good foot care, as diabetes medications can increase the risk of infections or poor circulation in the extremities.

Side Effects of Steglatro

Common Side Effects

  • Increased urination
  • Genital yeast infections
  • Urinary tract infections
  • Thirst

Uncommon/Severe Side Effects

  • Ketoacidosis (even in patients with type 2 diabetes)
  • Severe urinary tract infections
  • Dehydration
  • Hypotension (low blood pressure)

Risks and Warnings of Steglatro

  • Ketoacidosis: Though rare, Steglatro may cause ketoacidosis, a serious condition where the body produces high levels of blood acids. Seek medical attention immediately if you experience symptoms such as nausea, vomiting, abdominal pain, or difficulty breathing.
  • Increased Risk of Amputation: SGLT2 inhibitors, including Steglatro, may increase the risk of lower limb amputations in some patients. Proper foot care is essential, and any signs of sores, ulcers, or infections should be reported to a healthcare provider immediately.
  • Renal Function: Regular monitoring of kidney function is recommended, especially in patients with pre-existing kidney conditions.

Interactions with Steglatro

Common Drug Interactions

  • Diuretics: Using Steglatro with diuretics (water pills) may increase the risk of dehydration or low blood pressure.
  • Insulin or insulin secretagogues: Combining Steglatro with insulin or drugs that increase insulin production may increase the risk of hypoglycemia (low blood sugar).
  • ACE inhibitors or ARBs: These blood pressure medications may enhance the effect of Steglatro on lowering blood pressure, which can sometimes lead to dizziness or fainting.

Alternatives to Steglatro

  • Farxiga (dapagliflozin): Another SGLT2 inhibitor, used for type 2 diabetes, heart failure, and chronic kidney disease.
  • Jardiance (empagliflozin): An SGLT2 inhibitor that helps manage type 2 diabetes and also provides cardiovascular benefits.
  • Invokana (canagliflozin): Another SGLT2 inhibitor, with a similar mechanism of action as Steglatro, but it is also indicated for reducing the risk of cardiovascular events in type 2 diabetes patients.
  • Metformin: A common first-line treatment for type 2 diabetes, often used in combination with other medications.