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Stamaril
Stamaril is a yellow fever vaccine used to protect against yellow fever, a viral disease transmitted by mosquitoes. The vaccine is made from a live, attenuated (weakened) strain of the yellow fever virus and helps the immune system develop protection against the disease. Yellow fever is common in parts of Africa and South America, and vaccination with Stamaril is often required for travelers to these regions, as well as for residents of endemic areas. One dose of Stamaril typically provides lifetime protection for most individuals.
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Frequently Asked Questions
How long does the yellow fever vaccine last?
For most people, one dose of Stamaril provides lifetime protection. However, a booster dose may be required for certain high-risk individuals or those traveling to areas with high yellow fever transmission.
Do I need the yellow fever vaccine to travel?
You may need proof of vaccination to enter certain countries where yellow fever is endemic or if you are traveling from an area with yellow fever. Check the entry requirements of your destination country.
How long before travel should I get the yellow fever vaccine?
The vaccine should be administered at least 10 days before travel to ensure adequate protection against the virus.
Can children receive the yellow fever vaccine?
Yes, children over 9 months can receive the yellow fever vaccine, but it is contraindicated in infants younger than 6 months.
Can children receive the yellow fever vaccine?
Yes, children over 9 months can receive the yellow fever vaccine, but it is contraindicated in infants younger than 6 months.
What should I do if I experience serious side effects after receiving the vaccine?
Seek immediate medical attention if you experience symptoms of a severe allergic reaction (such as difficulty breathing or swelling), or if you develop neurological or severe systemic symptoms after vaccination.
Comprehensive Drug Guide
How Does Stamaril Work?
Stamaril works by stimulating the immune system to produce antibodies against the yellow fever virus. The vaccine contains a weakened form of the virus, which cannot cause disease in healthy individuals but is enough to trigger an immune response. This immune response results in the body creating long-lasting immunity to the yellow fever virus, typically providing protection for life after a single dose.
Common Dosages
- Stamaril is administered as a single injection of 0.5 mL subcutaneously (under the skin). Only one dose is typically needed for lifetime immunity, although a booster dose may be recommended for certain high-risk individuals (e.g., those traveling to areas with ongoing outbreaks).
Typical Dosing
- Single dose (0.5 mL) administered subcutaneously to individuals aged 9 months and older.
- A booster dose may be required for individuals at continued high risk of exposure (such as those traveling to areas with ongoing yellow fever transmission) or those with reduced immunity.
Typical Dosing
FDA Approved Indications
- Individuals aged 9 months and older who are traveling to or living in areas where yellow fever is endemic.
- Laboratory personnel who work with the yellow fever virus.
Who Shouldn't Take Stamaril?
- Severe allergic reactions (anaphylaxis) to any component of the vaccine, particularly egg proteins, as the vaccine is prepared in eggs.
- Infants younger than 6 months of age (due to an increased risk of severe adverse reactions).
- Individuals with immunosuppression, such as those undergoing chemotherapy or taking high doses of corticosteroids.
- Individuals with HIV/AIDS with severe immunosuppression.
- People with a history of thymus disorders (e.g., thymoma, thymectomy).
Advice From The Pharmacist
- Stamaril is usually administered at least 10 days before travel to ensure adequate protection. This time frame allows the body to develop immunity before potential exposure to the virus.
- After receiving Stamaril, you will be issued an International Certificate of Vaccination or Prophylaxis (ICVP), which may be required for entry into certain countries where yellow fever is endemic.
- Common side effects include mild reactions such as soreness at the injection site, headache, or mild fever. These usually resolve within a few days.
- More serious but rare side effects include yellow fever vaccine-associated neurotropic disease (YEL-AND) and yellow fever vaccine-associated viscerotropic disease (YEL-AVD), both of which require immediate medical attention.
- Store Stamaril in the refrigerator before use and ensure it is administered by a trained healthcare provider at a certified yellow fever vaccination center.
Side Effects of Stamaril
Common Side Effects
- ain, redness, or swelling at the injection site
- Headache
- Muscle aches
- Low-grade fever
- Fatigue
Uncommon/Severe Side Effects
- Yellow fever vaccine-associated neurotropic disease (YEL-AND), which can cause encephalitis or neurological symptoms such as confusion or seizures.
- Yellow fever vaccine-associated viscerotropic disease (YEL-AVD), which mimics yellow fever and can lead to organ failure.
- Severe allergic reactions (anaphylaxis), especially in individuals allergic to eggs.
Risks and Warnings of Stamaril
- Severe Allergic Reactions: Individuals with a history of severe allergies to eggs or vaccine components should not receive Stamaril, as it may trigger life-threatening allergic reactions.
- Age Restrictions: Stamaril is not recommended for infants under 6 months of age due to the increased risk of serious side effects.
- Immunosuppression: People with weakened immune systems (e.g., those with HIV or undergoing cancer treatment) are at risk for severe complications from the live vaccine. In these cases, the vaccine should not be administered.
- Travel to Endemic Areas: Some countries require proof of yellow fever vaccination for entry, and Stamaril is one of the few vaccines that must be certified by an authorized yellow fever vaccination center.
Interactions with Stamaril
Common Drug Interactions
- Immunosuppressive medications: People taking medications that weaken the immune system (such as corticosteroids, chemotherapy, or biologics) may have a reduced immune response to Stamaril or may experience severe side effects.
- Other live vaccines: If receiving other live vaccines, such as the MMR or varicella vaccine, it is recommended to space the administration of these vaccines by at least 4 weeks unless administered on the same day.
Alternatives to Stamaril
- DEET-based insect repellents
- Mosquito nets
- Wearing long sleeves and pants in areas with high mosquito activity
