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Spikevax

Spikevax is the brand name for the COVID-19 vaccine developed by Moderna. It is an mRNA-based vaccine that helps protect against the SARS-CoV-2 virus, which causes COVID-19. The vaccine works by prompting the body’s immune system to recognize and respond to the spike protein of the virus, reducing the risk of infection and severe illness. Spikevax is primarily used for preventing COVID-19 in individuals aged 6 months and older.

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Frequently Asked Questions

How long does Spikevax provide protection against COVID-19?
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Spikevax offers strong protection within weeks of completing the primary series, but protection wanes over time, which is why booster doses are recommended.

Can I get Spikevax if I’m pregnant or breastfeeding?
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Yes, Spikevax is considered safe for pregnant and breastfeeding individuals. The CDC recommends COVID-19 vaccination for these populations.

How effective is Spikevax against variants of COVID-19?
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Spikevax has shown strong efficacy against severe disease and hospitalization due to various COVID-19 variants, though protection against infection may be lower with certain variants like Omicron.

Can I receive Spikevax if I’ve had a prior COVID-19 infection?
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Yes, individuals who have recovered from COVID-19 are still advised to get vaccinated, as it can enhance immunity and protect against reinfection.

Is there a difference between Spikevax and Moderna COVID-19 vaccines?
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No, Spikevax is simply the brand name for the Moderna COVID-19 vaccine. Both refer to the same mRNA-based vaccine.

Comprehensive Drug Guide

How Does Spikevax Work?

Spikevax works by using messenger RNA (mRNA) to instruct cells in the body to produce a piece of the SARS-CoV-2 spike protein. This protein triggers an immune response, allowing the body to produce antibodies and activate T-cells that can fight off the virus if exposed in the future. The mRNA does not stay in the body but is broken down after the protein is made.

Common Dosages

  • Intramuscular injection: typically 0.5 mL per dose for adults and older children
  • Multi-dose vials containing 10 doses for administration in clinical settings

Typical Dosing

The typical dosing regimen for Spikevax is as follows:

  • Primary series: Two doses, given 28 days apart.
  • Booster dose: Recommended at least 6 months after the second dose, especially for individuals at higher risk of severe COVID-19.
  • For children: Dosing and scheduling vary based on age and immune status.

Typical Dosing

FDA Approved Indications

  • Adults and children aged 6 months and older
  • Booster doses for enhanced protection in previously vaccinated individuals
  • It may also be used in certain off-label scenarios where additional doses are needed for immunocompromised individuals.

Who Shouldn't Take Spikevax?

  • Known hypersensitivity to any ingredient in the vaccine, including polyethylene glycol (PEG)
  • A history of severe allergic reactions (e.g., anaphylaxis) to previous doses of mRNA vaccines or other related vaccines

Advice From The Pharmacist

  • Spikevax is administered via an intramuscular injection, usually in the upper arm.
  • Stay for 15-30 minutes after receiving the vaccine for monitoring, especially if you have a history of allergic reactions.
  • The most common side effects, such as soreness at the injection site and fatigue, typically resolve within a few days.
  • Contact a healthcare provider if you experience any severe side effects, such as chest pain, shortness of breath, or signs of a severe allergic reaction.

Side Effects of Spikevax

Common Side Effects

  • Soreness, redness, or swelling at the injection site
  • Fatigue
  • Headache
  • Muscle or joint pain
  • Fever or chills

Uncommon/Severe Side Effects

  • Myocarditis or pericarditis (inflammation of the heart or surrounding tissue), particularly in younger males
  • Severe allergic reactions such as anaphylaxis

Risks and Warnings of Spikevax

  • Allergic Reactions: Individuals with a history of severe allergic reactions to any component of Spikevax should avoid receiving the vaccine.
  • Myocarditis and Pericarditis: Cases of myocarditis and pericarditis have been reported, particularly in males under the age of 30. Seek immediate medical attention if chest pain, shortness of breath, or palpitations occur after vaccination.
  • Immune response risks: Immunocompromised individuals may not mount as strong a response and may need additional doses or boosters.

Interactions with Spikevax

Common Drug Interactions

  • Other vaccines: Spikevax can be given at the same time as other vaccines, such as the flu shot, but in different injection sites.
  • Immunosuppressive therapies: These medications may reduce the effectiveness of Spikevax, and patients should consult their doctor for guidance on optimal timing for vaccination.

Alternatives to Spikevax

  • Comirnaty (Pfizer-BioNTech COVID-19 vaccine): Another mRNA-based vaccine used for similar age groups.
  • Janssen (Johnson & Johnson COVID-19 vaccine): A viral vector vaccine that only requires a single-dose primary series.
  • Novavax COVID-19 vaccine: A protein subunit vaccine, an alternative for individuals who may not be able to receive mRNA vaccines.