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Sotylize
Sotylize (sotagliflozin) is an oral antihyperglycemic medication used to manage type 1 and type 2 diabetes. It belongs to the class of drugs known as SGLT2 inhibitors. Sotagliflozin works by preventing the reabsorption of glucose in the kidneys, leading to increased glucose excretion in urine, thereby helping to lower blood sugar levels. It also promotes weight loss and has beneficial effects on cardiovascular health.
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Frequently Asked Questions
How quickly does Sotylize work?
Sotylize usually starts to lower blood sugar levels within a few days of initiation, with optimal effects seen over a few weeks.
Can I use Sotylize if I have type 2 diabetes?
Yes, Sotylize is FDA-approved for use in adults with type 2 diabetes, either alone or in combination with insulin.
What should I do if I miss a dose of Sotylize?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Sotylize safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding, as the safety of Sotylize during these periods should be evaluated on a case-by-case basis.
Are there any dietary restrictions while taking Sotylize?
While there are no specific dietary restrictions, maintaining a balanced diet and regular monitoring of carbohydrate intake can help optimize diabetes management. Always follow your healthcare provider's dietary recommendations.
Comprehensive Drug Guide
How Does Sotylize Work?
Sotagliflozin inhibits the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, which is responsible for the reabsorption of glucose back into the bloodstream. By blocking this transporter, sotagliflozin increases glucose excretion in urine, leading to lower blood glucose levels. This mechanism also helps reduce calorie intake and promotes weight loss.
Common Dosages
- Tablets: Common strengths include 200 mg and 400 mg.
Typical Dosing
- For type 1 diabetes: The usual starting dose is 200 mg once daily, which may be adjusted based on individual response and tolerability.
- For type 2 diabetes: The starting dose is typically 200 mg once daily, with a maximum dose of 400 mg.
Typical Dosing
FDA Approved Indications
- Management of blood sugar levels in adults with type 1 diabetes in conjunction with insulin therapy.
- Management of blood sugar levels in adults with type 2 diabetes.
Who Shouldn't Take Sotylize?
- Known hypersensitivity to sotagliflozin or any components of the formulation.
- Severe renal impairment (eGFR < 30 mL/min).
- A history of serious hypersensitivity reactions or diabetic ketoacidosis.
Advice From The Pharmacist
- Take Sotylize exactly as prescribed by your healthcare provider. It can be taken with or without food.
- Monitor your blood glucose levels regularly, especially when starting or adjusting the dose.
- Be aware of the signs of low blood sugar (hypoglycemia) and diabetic ketoacidosis, especially if used in conjunction with insulin.
- Maintain hydration, as Sotylize can increase urination.
Side Effects of Sotylize
Common Side Effects
- Nausea
- Diarrhea
- Genital fungal infections (e.g., yeast infections)
- Urinary tract infections
Uncommon/Severe Side Effects
- Diabetic ketoacidosis
- Severe allergic reactions (rash, itching, swelling)
- Acute kidney injury
Risks and Warnings of Sotylize
- Ketoacidosis Risk: Patients with type 1 diabetes using Sotylize should be monitored closely for signs of ketoacidosis, which can be life-threatening.
- Renal Function: Regular monitoring of renal function is recommended, as Sotylize may impact kidney health, especially in patients with pre-existing conditions.
Interactions with Sotylize
Common Drug Interactions
- Insulin and Insulin Secretagogues: Caution should be exercised when combining Sotylize with insulin or other diabetes medications, as this may increase the risk of hypoglycemia.
- Diuretics: Concurrent use may increase the risk of dehydration and hypotension.
Alternatives to Sotylize
- Other SGLT2 Inhibitors: Such as canagliflozin or empagliflozin for similar indications.
- GLP-1 Receptor Agonists: Like liraglutide or semaglutide, which can also help manage blood sugar levels.
