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Soriatane
Soriatane (acitretin) is an oral retinoid medication used primarily for the treatment of severe psoriasis and other keratinization disorders. It is a derivative of vitamin A that works by regulating skin cell production and promoting normal skin cell growth. Soriatane helps to reduce the symptoms of psoriasis, such as scaling, redness, and thickness of the skin, leading to significant improvement in skin condition.
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Frequently Asked Questions
How long does it take for Soriatane to work?
Patients may begin to see improvement in their psoriasis symptoms within several weeks, but optimal results may take several months.
Can I stop taking Soriatane suddenly?
It is important to consult your healthcare provider before stopping Soriatane, as they may recommend a gradual tapering of the dose.
Is Soriatane safe during pregnancy?
No, Soriatane is contraindicated in pregnancy due to the high risk of severe birth defects.
What should I do if I miss a dose of Soriatane?
If you miss a dose, take it as soon as you remember. If it’s close to the next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Soriatane?
Patients are advised to avoid alcohol while on Soriatane, as it can increase the risk of liver toxicity. Always follow your healthcare provider's dietary recommendations.
Comprehensive Drug Guide
How Does Soriatane Work?
Acitretin, the active ingredient in Soriatane, works by affecting the growth and differentiation of skin cells. It normalizes the process of keratinization and reduces the proliferation of skin cells, which is particularly beneficial in managing conditions like psoriasis. Additionally, it has anti-inflammatory properties that help to decrease redness and irritation in the affected skin areas.
Common Dosages
- Capsules: Common strengths include 10 mg, 25 mg, and 30 mg.
Typical Dosing
- For psoriasis: The typical starting dose is usually between 25 mg and 50 mg once daily, adjusted based on response and tolerability. The maximum recommended dose is generally 50 mg per day.
Typical Dosing
FDA Approved Indications
- Treatment of severe psoriasis in adults and children over the age of 12.
- Treatment of other skin disorders related to abnormal keratinization.
Who Shouldn't Take Soriatane?
- Known hypersensitivity to acitretin or any components of the formulation.
- Pregnancy or those planning to become pregnant, as it can cause severe birth defects.
- Liver disease or excessive alcohol consumption.
Advice From The Pharmacist
- Take Soriatane exactly as prescribed by your healthcare provider. Do not exceed the recommended dose.
- Use effective contraception during treatment and for at least three years after stopping the medication, as it can cause serious birth defects.
- Avoid alcohol consumption, as it can increase the risk of liver toxicity.
- Report any unusual symptoms, such as severe headaches, vision changes, or signs of liver problems (e.g., yellowing of the skin or eyes) to your healthcare provider immediately.
Side Effects of Soriatane
Common Side Effects
- Dry skin and lips
- Itching
- Hair loss
- Elevated liver enzymes
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Severe headache or blurred vision
- Symptoms of depression or mood changes
Risks and Warnings of Soriatane
- Teratogenicity: Acitretin is highly teratogenic; women of childbearing potential must be counseled on effective contraception.
- Liver Function: Liver function should be monitored regularly during treatment due to the potential for liver toxicity.
Interactions with Soriatane
Common Drug Interactions
- Other Retinoids: Concurrent use of other retinoid medications should be avoided due to the increased risk of side effects.
- Tetracycline Antibiotics: These should be used with caution, as they can increase the risk of intracranial hypertension.
Alternatives to Soriatane
- Other Treatments for Psoriasis: Alternatives may include topical treatments, phototherapy, and other systemic medications such as methotrexate or biologics.
