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Sod Citrate-Citric Acid

Sodium Citrate-Citric Acid is a combination medication used primarily as a buffering agent and to manage conditions related to urinary acidity. It helps in maintaining a neutral pH in the urine, making it beneficial for patients with urinary tract infections (UTIs) or those prone to the formation of certain types of kidney stones. By alkalizing the urine, it can aid in reducing the pain associated with acidic urine and promote the dissolution of uric acid and cystine stones.



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Frequently Asked Questions

How long does it take for Sodium Citrate-Citric Acid to work?
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Patients may begin to notice relief from symptoms associated with urinary acidity within a few days of starting treatment.

Can I take Sodium Citrate-Citric Acid with other medications?
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Always consult your healthcare provider before combining it with other medications to avoid potential interactions.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up.

Is Sodium Citrate-Citric Acid safe for long-term use?
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While generally safe for short-term use, long-term treatment should be monitored by a healthcare provider due to the potential for electrolyte imbalances.

Are there any dietary restrictions while taking Sodium Citrate-Citric Acid?
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There are no specific dietary restrictions, but maintaining a balanced diet and adequate hydration is encouraged. Always consult your healthcare provider for personalized advice.

Comprehensive Drug Guide

How Does Sod Citrate-Citric Acid Work?

Sodium Citrate and Citric Acid work together to alkalinize the urine. Sodium Citrate is metabolized to bicarbonate, which increases bicarbonate levels in the blood and promotes a more alkaline urine pH. This change in urine acidity can help dissolve certain types of kidney stones and alleviate discomfort associated with acidic urine.



Common Dosages

  • Oral solutions: Typically containing 1-2 g of sodium citrate and citric acid per dose.
  • Powdered preparations: Meant to be dissolved in water before ingestion.

Typical Dosing

  • For urinary alkalinization: The usual adult dose is 1-2 tablespoons of the solution taken 2-3 times a day, diluted in water. Dosage may vary based on the patient's condition and response.
  • For children: Dosing is adjusted based on age and weight; consult a healthcare provider for specific recommendations.


Typical Dosing

FDA Approved Indications

  • Management of metabolic acidosis
  • Prevention of certain types of urinary stones
  • Treatment of urinary tract infections to promote alkalinization of urine.


Who Shouldn't Take Sod Citrate-Citric Acid?

  • Known hypersensitivity to sodium citrate, citric acid, or any components of the formulation.
  • Severe renal impairment or significant electrolyte imbalances.
  • Conditions that require a low-sodium diet, such as certain heart conditions.


Advice From The Pharmacist

  • Take Sodium Citrate-Citric Acid exactly as directed by your healthcare provider. Mix the solution in water to help improve palatability and absorption.
  • Maintain adequate hydration while using this medication, as it can promote urine alkalinization and help prevent stone formation.
  • Regularly monitor your urinary pH as recommended by your healthcare provider to assess treatment efficacy.
  • Store the medication at room temperature and keep it out of reach of children.


Side Effects of Sod Citrate-Citric Acid

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort


Uncommon/Severe Side Effects

  • Electrolyte imbalances, particularly with prolonged use.
  • Allergic reactions such as rash or difficulty breathing.


Risks and Warnings of Sod Citrate-Citric Acid

  • Electrolyte Imbalances: Prolonged use may lead to imbalances in electrolytes, especially sodium and potassium. Regular monitoring is advised for long-term users.
  • Renal Monitoring: Patients with existing kidney conditions should be closely monitored, as sodium citrate can affect kidney function and electrolyte balance.


Interactions with Sod Citrate-Citric Acid

Common Drug Interactions

  • Diuretics: The use of sodium citrate with certain diuretics may increase the risk of electrolyte imbalances.
  • Other Medications: Consult your healthcare provider about any other medications you are taking, as they may interact with sodium citrate-citric acid.


Alternatives to Sod Citrate-Citric Acid

  • Potassium Citrate: Another urinary alkalinizer that may be used to prevent kidney stones.
  • Alkalizing Agents: Other agents used to manage metabolic acidosis or urinary pH include bicarbonate salts.