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Siliq
Siliq (brodalumab) is a monoclonal antibody used for the treatment of moderate to severe plaque psoriasis in adults. It targets the interleukin-17 receptor A (IL-17RA), which plays a significant role in the inflammatory process associated with psoriasis. By blocking this receptor, Siliq helps to reduce the symptoms of psoriasis, including redness, scaling, and plaque formation.
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Frequently Asked Questions
How quickly does Siliq start to work?
Patients may begin to notice improvements in their psoriasis symptoms within 1 to 3 weeks, but optimal results may take several weeks to months.
Can I use Siliq while pregnant or breastfeeding?
Consult your healthcare provider before using Siliq if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Siliq?
There are no specific dietary restrictions associated with the use of Siliq.
What should I do if I miss a dose of Siliq?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Siliq safe for long-term use?
Siliq can be safe for long-term use under medical supervision for managing moderate to severe plaque psoriasis. Regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Siliq Work?
- Inhibiting IL-17 signaling: Brodalumab binds to the IL-17 receptor A, preventing the action of IL-17A, a pro-inflammatory cytokine. This blockade helps to reduce the inflammatory response and the associated symptoms of psoriasis.
Common Dosages
- Subcutaneous injection: The standard concentration is 210 mg/mL.
Typical Dosing
- The usual dosing schedule for Siliq involves an initial dose of 210 mg administered subcutaneously at weeks 0, 1, and 2, followed by a maintenance dose of 210 mg every 2 weeks thereafter.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Who Shouldn't Take Siliq?
- Known hypersensitivity to brodalumab or any components of the formulation.
- Active infections, as immunosuppression may worsen these conditions.
Advice From The Pharmacist
- Instruct patients on the proper technique for self-injection and the importance of adhering to the dosing schedule.
- Advise patients to monitor for signs of infection, including fever, chills, or persistent cough, and to contact their healthcare provider if these occur.
- Discuss potential side effects, including injection site reactions, headaches, and increased risk of infections, and encourage patients to report any severe or unusual symptoms.
Side Effects of Siliq
Common Side Effects
- Injection site reactions (such as redness, itching, or swelling)
- Headache
- Fatigue
- Diarrhea
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing).
- Increased risk of infections, including tuberculosis and opportunistic infections.
Risks and Warnings of Siliq
- Infection Risk: Siliq can lower the immune system's ability to fight infections. Patients should be screened for latent tuberculosis and monitored for signs of infection during treatment.
- Mental Health Effects: There have been reports of suicidal ideation and behavior in patients receiving brodalumab. Patients should be monitored for changes in mood or behavior.
Interactions with Siliq
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, especially other immunosuppressants or biologics, as these can increase the risk of infections.
Alternatives to Siliq
- Other Psoriasis Treatments: Alternatives may include other biologics targeting IL-17 (such as secukinumab) or TNF-alpha inhibitors, as well as traditional systemic treatments or phototherapy depending on the specific needs of the patient.
