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Seysara
Seysara (generic name: sarecycline) is an oral antibiotic used to treat moderate to severe acne vulgaris in patients aged 9 years and older. It belongs to the class of tetracycline antibiotics and works by reducing inflammation and killing bacteria that contribute to acne. Unlike some other antibiotics, Seysara is more targeted toward the bacteria involved in acne, which may lead to fewer gastrointestinal side effects. It is typically prescribed for long-term use to help control persistent acne.
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Frequently Asked Questions
How long does it take for Seysara to start working?
Improvements in acne may be seen after a few weeks, but it may take up to 12 weeks for the full benefit to be noticed. Continue using Seysara as directed by your doctor.
How long does it take for Seysara to start working?
Improvements in acne may be seen after a few weeks, but it may take up to 12 weeks for the full benefit to be noticed. Continue using Seysara as directed by your doctor.
Can Seysara be used with other acne treatments?
Yes, Seysara can be used in combination with other acne treatments, such as topical retinoids or benzoyl peroxide. Consult your healthcare provider to develop a treatment plan that suits your needs.
Can I take Seysara with food?
Yes, Seysara can be taken with or without food. However, taking it with food may help reduce stomach upset.
Can I use Seysara for conditions other than acne?
Seysara is specifically approved for the treatment of acne. It should not be used for other conditions unless prescribed by your doctor.
Can I use Seysara for conditions other than acne?
Seysara is specifically approved for the treatment of acne. It should not be used for other conditions unless prescribed by your doctor.
What should I do if I miss a dose of Seysara?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take the next dose as usual. Do not take two doses at once.
Comprehensive Drug Guide
How Does Seysara Work?
Seysara works by inhibiting protein synthesis in bacteria, specifically targeting the bacteria that contribute to acne formation, such as Cutibacterium acnes (formerly known as Propionibacterium acnes). By reducing bacterial growth and inflammation, Seysara helps to prevent the formation of acne lesions and reduce redness and swelling in existing acne. It also has anti-inflammatory properties, which make it effective in treating acne-related inflammation.
Common Dosages
- 60 mg tablets
- 100 mg tablets
- 150 mg tablets
Typical Dosing
- The typical dose of Seysara is based on body weight. The usual recommended dose is 1.5 mg per kilogram of body weight once daily.
- For patients weighing 33 to 54 kg (73 to 119 lbs), the dose is 60 mg once daily.
- For patients weighing 55 to 84 kg (120 to 185 lbs), the dose is 100 mg once daily.
- For patients weighing 85 to 136 kg (186 to 299 lbs), the dose is 150 mg once daily.
- Seysara is usually taken once daily with or without food. It is recommended to take the medication with a full glass of water to reduce the risk of irritation to the esophagus.
Typical Dosing
FDA Approved Indications
- Moderate to severe acne vulgaris in patients aged 9 years and older.
Who Shouldn't Take Seysara?
- Known hypersensitivity to sarecycline, any other tetracyclines, or any components of the formulation.
- Use during pregnancy or in children under 8 years of age, as tetracyclines can affect bone growth and cause permanent tooth discoloration.
Advice From The Pharmacist
- Seysara should be taken once daily, with or without food. However, it is best to take it with a full glass of water to prevent irritation of the esophagus.
- Avoid taking Seysara at the same time as antacids, calcium supplements, iron supplements, or multivitamins, as these can interfere with the absorption of the medication. Take these products at least 2 hours before or after taking Seysara.
- Protect your skin from sunlight by using sunscreen and wearing protective clothing, as Seysara can increase your skin's sensitivity to sunlight (photosensitivity).
- Do not use Seysara if you are pregnant or planning to become pregnant, as tetracycline antibiotics can harm a developing fetus.
- Complete the full course of treatment as prescribed by your doctor, even if you notice improvements in your acne, to prevent the recurrence of symptoms.
Side Effects of Seysara
Common Side Effects
- Nausea
- Dizziness
- Headache
- Photosensitivity (increased sensitivity to sunlight)
Uncommon/Severe Side Effects
- Allergic reactions, including rash, itching, swelling, or difficulty breathing
- Severe skin reactions, such as Stevens-Johnson syndrome
- Intracranial hypertension (increased pressure in the brain), which can cause headaches, vision changes, or nausea
Risks and Warnings of Seysara
- Photosensitivity: Seysara can make your skin more sensitive to sunlight, leading to a higher risk of sunburn. Avoid prolonged sun exposure and use sunscreen with an SPF of at least 30.
- Permanent tooth discoloration: Like other tetracyclines, Seysara may cause permanent yellowing or graying of the teeth in children under 8 years and should be avoided in this age group.
- Intracranial Hypertension: Rarely, tetracyclines can cause increased pressure in the brain, leading to symptoms such as persistent headache or visual changes. If these symptoms occur, discontinue the medication and seek medical attention.
- Antibiotic resistance: Long-term use of antibiotics like Seysara can contribute to the development of antibiotic-resistant bacteria. Follow your doctor's instructions carefully, and do not use this medication for conditions it was not prescribed for.
Interactions with Seysara
Common Drug Interactions
- Antacids and supplements: Products containing calcium, magnesium, aluminum, or iron can reduce the absorption of Seysara. Take these products at least 2 hours before or after taking Seysara.
- Oral contraceptives: Like other antibiotics, Seysara may reduce the effectiveness of hormonal birth control. Use additional non-hormonal contraceptive methods while taking Seysara.
- Isotretinoin (Accutane): Combining Seysara with isotretinoin may increase the risk of intracranial hypertension. Avoid taking both medications together.
Alternatives to Seysara
- Doxycycline: Another tetracycline antibiotic commonly used for acne, with a broader range of uses for other bacterial infections as well.
- Minocycline: A tetracycline antibiotic often used for treating acne, available in oral and topical formulations.
- Topical antibiotics (e.g., clindamycin, erythromycin): These can be applied directly to the skin for milder cases of acne.
- Retinoids (e.g., tretinoin, adapalene): Topical retinoids are often used in combination with antibiotics to reduce acne and prevent new lesions from forming.
