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Sensipar
Sensipar (cinacalcet) is a calcimimetic agent used primarily to manage secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on dialysis, as well as to treat hypercalcemia in patients with parathyroid carcinoma or primary hyperparathyroidism when surgery is not an option. It works by increasing the sensitivity of calcium-sensing receptors to calcium, thereby reducing parathyroid hormone (PTH) secretion and lowering serum calcium levels.
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Frequently Asked Questions
How quickly does Sensipar start to work?
Patients may begin to see a reduction in PTH levels within 1 week of starting treatment, but full effects can take several weeks.
Can I use Sensipar while pregnant or breastfeeding?
Consult your healthcare provider before using Sensipar if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Sensipar?
There are no specific dietary restrictions associated with the use of Sensipar, but patients should maintain a balanced diet to help manage calcium levels.
What should I do if I miss a dose of Sensipar?
If you miss a dose, take it as soon as you remember, but only if it's within the same day. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Sensipar safe for long-term use?
Sensipar is generally considered safe for long-term use under medical supervision for managing hyperparathyroidism and hypercalcemia. Regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Sensipar Work?
- Activating calcium-sensing receptors in the parathyroid glands: This action mimics the effects of calcium, leading to decreased secretion of PTH and a subsequent reduction in serum calcium levels.
Common Dosages
- Tablets: Common strengths include 30 mg, 60 mg, and 90 mg.
Typical Dosing
- For secondary hyperparathyroidism: The usual starting dose is 30 mg taken orally once daily, which may be adjusted based on serum calcium and PTH levels, typically ranging from 30 mg to 180 mg per day.
- For hypercalcemia: The dosage may vary based on individual patient needs and responses.
Typical Dosing
FDA Approved Indications
- Treatment of secondary hyperparathyroidism in patients with CKD on dialysis.
- Treatment of hypercalcemia in patients with parathyroid carcinoma.
- Treatment of hypercalcemia in patients with primary hyperparathyroidism when surgical intervention is not appropriate.
Who Shouldn't Take Sensipar?
- Known hypersensitivity to cinacalcet or any components of the formulation.
- Hypocalcemia (low serum calcium levels) prior to treatment.
Advice From The Pharmacist
- Instruct patients to take Sensipar with food to enhance absorption.
- Advise patients to have their serum calcium levels monitored regularly, especially when starting treatment or adjusting the dose.
- Discuss potential side effects, including nausea, vomiting, and gastrointestinal disturbances, and encourage patients to report any severe or unusual symptoms.
Side Effects of Sensipar
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing).
- Hypocalcemia (low serum calcium levels), which can lead to muscle spasms or seizures.
Risks and Warnings of Sensipar
- Monitoring of Calcium Levels: Regular monitoring of serum calcium is essential to prevent hypocalcemia and its associated complications.
- Gastrointestinal Effects: Patients should be advised to report any severe gastrointestinal symptoms, as they may indicate the need for dosage adjustment.
Interactions with Sensipar
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, especially those affecting calcium levels, such as vitamin D or calcium supplements, as these can interact with Sensipar.
Alternatives to Sensipar
- Other Treatments for Hyperparathyroidism: Alternatives may include other calcimimetic agents or surgical options for managing hyperparathyroidism depending on the patient's condition and treatment history.
