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Segluromet
Segluromet (ertugliflozin and metformin) is a combination medication used to improve glycemic control in adults with type 2 diabetes mellitus. This medication combines an SGLT2 inhibitor (ertugliflozin) with metformin, a well-known antidiabetic agent. It helps lower blood sugar levels by increasing glucose excretion through urine and improving insulin sensitivity.
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Frequently Asked Questions
How quickly does Segluromet start to work?
Patients may begin to see improvements in their blood sugar levels within a few days of starting Segluromet, but optimal control may take several weeks.
Can I use Segluromet while pregnant or breastfeeding?
Consult your healthcare provider before using Segluromet if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Segluromet?
There are no specific dietary restrictions associated with the use of Segluromet, but maintaining a balanced diet and regular physical activity is encouraged for optimal diabetes management.
What should I do if I miss a dose of Segluromet?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Segluromet safe for long-term use?
Segluromet is generally safe for long-term use under medical supervision for managing type 2 diabetes. Regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Segluromet Work?
- Ertugliflozin: This SGLT2 inhibitor works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in urine and reduced blood sugar levels.
- Metformin: It improves insulin sensitivity and decreases hepatic glucose production, which helps lower blood sugar levels.
Common Dosages
- Tablets: Common strengths include 5 mg of ertugliflozin and 500 mg of metformin, and 15 mg of ertugliflozin and 1000 mg of metformin.
Typical Dosing
- The usual starting dose is 5 mg/500 mg taken orally once daily, with potential adjustments based on blood sugar control and tolerance. Doses can be increased to the 15 mg/1000 mg combination as needed.
Typical Dosing
FDA Approved Indications
- Management of blood sugar levels in adults with type 2 diabetes mellitus, typically when diet and exercise alone do not provide adequate glycemic control.
Who Shouldn't Take Segluromet?
- Known hypersensitivity to ertugliflozin, metformin, or any components of the formulation.
- Severe renal impairment (eGFR < 30 mL/min).
- Active metabolic acidosis, including diabetic ketoacidosis.
Advice From The Pharmacist
- Instruct patients to take Segluromet as prescribed and to maintain a consistent schedule to maximize effectiveness.
- Advise patients to monitor their blood sugar levels regularly and report any significant changes or symptoms of hypoglycemia.
- Discuss potential side effects, including gastrointestinal issues and the risk of urinary tract infections, and encourage patients to report any severe or unusual symptoms.
Side Effects of Segluromet
Common Side Effects
- Nausea or vomiting
- Diarrhea
- Abdominal pain
- Increased urination
Uncommon/Severe Side Effects
- Lactic acidosis (a rare but serious metabolic complication of metformin).
- Urinary tract infections or genital mycotic infections.
Risks and Warnings of Segluromet
- Renal Monitoring: Regular monitoring of renal function is essential, as both components of Segluromet can affect kidney health.
- Lactic Acidosis: Patients should be aware of the symptoms of lactic acidosis, including muscle pain, difficulty breathing, and unusual tiredness, and seek immediate medical attention if these occur.
Interactions with Segluromet
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, particularly those that affect renal function or blood sugar levels, to avoid potential interactions.
Alternatives to Segluromet
- Other Antidiabetic Medications: Alternatives may include other SGLT2 inhibitors or different classes of diabetes medications such as DPP-4 inhibitors, GLP-1 receptor agonists, or sulfonylureas, depending on the specific condition and individual patient needs.
