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Savaysa
Savaysa (edoxaban) is an oral anticoagulant used to reduce the risk of stroke and blood clots in patients with nonvalvular atrial fibrillation and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a factor Xa inhibitor, which means it works by blocking the activity of factor Xa, an essential component in the blood coagulation process.
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Frequently Asked Questions
How quickly does Savaysa start to work?
Savaysa typically starts to provide anticoagulation effects within 1 to 2 hours after administration, but the full therapeutic effect may take longer.
Can I use Savaysa while pregnant or breastfeeding?
Consult your healthcare provider before using Savaysa if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Savaysa?
There are no specific dietary restrictions associated with the use of Savaysa, but maintaining a consistent diet is advised to help manage anticoagulation levels.
What should I do if I miss a dose of Savaysa?
If you miss a dose, take it as soon as you remember on the same day. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Savaysa safe for long-term use?
Savaysa is generally considered safe for long-term use under medical supervision for the management of stroke prevention and thrombosis. Regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Savaysa Work?
- Inhibiting factor Xa: Edoxaban selectively inhibits factor Xa, leading to a decrease in thrombin generation and a reduction in clot formation. This mechanism helps to prevent the formation of blood clots in patients at risk.
Common Dosages
- Tablets: Common strengths include 15 mg, 30 mg, and 60 mg.
Typical Dosing
- For nonvalvular atrial fibrillation: The typical dose is 60 mg once daily, with adjustments based on renal function and body weight.
- For DVT and PE: The initial dose is usually 60 mg once daily, following a treatment period with a parenteral anticoagulant.
Typical Dosing
FDA Approved Indications
- Prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
- Treatment of DVT and PE.
- Reduction in the risk of recurrence of DVT and PE after initial treatment.
Who Shouldn't Take Savaysa?
- Active bleeding or significant bleeding disorders.
- Severe renal impairment (eGFR < 15 mL/min).
- Known hypersensitivity to edoxaban or any components of the formulation.
Advice From The Pharmacist
- Instruct patients to take Savaysa at the same time each day, with or without food.
- Advise patients to inform all healthcare providers about their use of Savaysa, especially before any surgical or dental procedures.
- Discuss potential side effects, including bleeding risks, and encourage patients to report any unusual bruising, bleeding, or signs of anemia.
Side Effects of Savaysa
Common Side Effects
- Bleeding or bruising
- Nausea
- Fatigue
- Liver enzyme elevations (monitoring may be necessary)
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing).
- Significant bleeding events, including gastrointestinal or intracranial bleeding.
Risks and Warnings of Savaysa
- Bleeding Risk: Patients should be closely monitored for signs of bleeding, particularly those with risk factors such as advanced age or concurrent use of other anticoagulants.
- Renal Function: Renal function should be assessed before and during treatment, as it can affect dosing and safety.
Interactions with Savaysa
Common Drug Interactions
- Other Anticoagulants: Patients should inform their healthcare provider about all medications they are taking, especially other anticoagulants or medications that affect bleeding, as these can increase the risk of bleeding.
Alternatives to Savaysa
- Other Anticoagulants: Alternatives may include warfarin or other direct oral anticoagulants (DOACs) such as rivaroxaban or apixaban, depending on individual patient needs and specific clinical situations.
