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Sancuso
Sancuso (granisetron) is a 5-HT3 receptor antagonist used primarily for the prevention of nausea and vomiting associated with chemotherapy and radiation therapy. It is formulated as a transdermal patch that allows for continuous delivery of medication, providing a convenient method for managing nausea and vomiting over an extended period.
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Frequently Asked Questions
How quickly does Sancuso start to work?
Patients may begin to notice relief from nausea within 24 hours after applying the patch, with continued effectiveness throughout the wear time.
Can I use Sancuso while pregnant or breastfeeding?
Consult your healthcare provider before using Sancuso if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Sancuso?
There are no specific dietary restrictions associated with the use of Sancuso, but patients should maintain adequate hydration and follow their healthcare provider's advice regarding diet during chemotherapy.
What should I do if I miss a dose of Sancuso?
If you miss applying a patch, apply it as soon as you remember if it is still within the timeframe for use. If it is close to the time for your next patch application, skip the missed patch and continue with your regular schedule. Do not apply multiple patches at once.
Is Sancuso safe for long-term use?
Sancuso is intended for use during specific chemotherapy or radiation treatment courses. Long-term use should be monitored by a healthcare provider to assess effectiveness and any potential side effects. Regular follow-ups are important for ongoing management.
Comprehensive Drug Guide
How Does Sancuso Work?
- Blocking serotonin receptors: Granisetron inhibits the action of serotonin at the 5-HT3 receptors in the gastrointestinal tract and the central nervous system, effectively reducing nausea and the urge to vomit.
Common Dosages
- Transdermal patch: Each patch delivers 3.1 mg of granisetron over a 7-day period.
Typical Dosing
- The usual recommended dose is to apply one patch to a clean, dry area of the skin at least 24 hours before chemotherapy or radiation treatment. The patch should be worn for up to 7 days.
Typical Dosing
FDA Approved Indications
- Prevention of nausea and vomiting associated with highly and moderately emetogenic chemotherapy.
- Prevention of nausea and vomiting due to radiation therapy.
Who Shouldn't Take Sancuso?
- Known hypersensitivity to granisetron or any components of the formulation.
- Use in patients with a history of hypersensitivity reactions to other 5-HT3 antagonists.
Advice From The Pharmacist
- Instruct patients on how to apply the patch properly and to avoid exposing it to excessive moisture or heat, as this can affect its effectiveness.
- Advise patients to monitor for any signs of irritation at the application site and to report any severe or unusual symptoms, such as persistent nausea or vomiting.
- Discuss the importance of adhering to the prescribed schedule for patch application in relation to chemotherapy or radiation treatment.
Side Effects of Sancuso
Common Side Effects
- Headache
- Constipation
- Dizziness
- Skin irritation or rash at the application site
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing).
Risks and Warnings of Sancuso
- Caution in Cardiac Patients: Use with caution in patients with a history of cardiac conditions, as serotonin receptor antagonists can affect heart rhythm.
- Monitor Efficacy: Patients should be monitored for control of nausea and vomiting, and therapy adjustments may be necessary if symptoms persist.
Interactions with Sancuso
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, especially those that can affect serotonin levels or cardiac function, to avoid potential interactions.
Alternatives to Sancuso
- Other Antiemetics: Alternatives may include other 5-HT3 receptor antagonists like ondansetron or palonosetron, as well as non-pharmacological interventions depending on the specific needs of the patient.
