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Sabril
Sabril (vigabatrin) is an anticonvulsant medication used primarily for the treatment of refractory complex partial seizures in adults and for infantile spasms in children. It works by inhibiting the enzyme GABA transaminase, leading to an increase in the levels of gamma-aminobutyric acid (GABA), a neurotransmitter that has inhibitory effects in the central nervous system, thereby helping to control seizures.
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Frequently Asked Questions
How quickly does Sabril start to work?
Patients may begin to notice a reduction in seizure frequency within a few weeks of starting Sabril, but it may take several months to achieve optimal control.
Can I stop taking Sabril suddenly?
It is generally not advisable to stop taking Sabril abruptly without consulting your healthcare provider, as this can lead to a resurgence of seizures.
Are there any specific dietary restrictions while taking Sabril?
There are no specific dietary restrictions; however, maintaining a balanced diet can support overall health.
What should I do if I miss a dose of Sabril?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Sabril safe for long-term use?
Sabril can be used long-term under medical supervision, but regular monitoring of vision and mental health is essential to ensure patient safety and treatment efficacy.
Comprehensive Drug Guide
How Does Sabril Work?
Vigabatrin works by irreversibly inhibiting GABA transaminase, the enzyme responsible for the breakdown of GABA in the brain. This inhibition results in increased levels of GABA, enhancing its inhibitory effects on neuronal activity, which helps in controlling seizures and reducing excitability in the brai
Common Dosages
- Tablets: 500 mg.
- Oral powder: 500 mg packets for reconstitution.
Typical Dosing
- For adults with complex partial seizures: The usual starting dose is 500 mg taken twice daily, which may be increased based on clinical response and tolerability, with a maximum dose of 3 grams per day.
- For infantile spasms: The typical starting dose is 150 mg/kg/day, divided into two doses, with adjustments made based on clinical response.
Typical Dosing
FDA Approved Indications
- Treatment of refractory complex partial seizures in adults.
- Treatment of infantile spasms in children aged 1 month to 2 years.
Who Shouldn't Take Sabril?
- Known hypersensitivity to vigabatrin or any components of the formulation.
- History of severe vision loss (as it may exacerbate existing conditions).
Advice From The Pharmacist
- Inform patients about the risk of vision loss associated with Sabril, including peripheral vision impairment, and advise them to have regular eye exams while on treatment.
- Instruct patients to take Sabril exactly as prescribed and not to discontinue it abruptly without consulting their healthcare provider.
- Monitor for any signs of new or worsening seizures and report them to their healthcare provider promptly.
Side Effects of Sabril
Common Side Effects
- Drowsiness
- Fatigue
- Dizziness
- Weight gain
- Visual field defects
Uncommon/Severe Side Effects
- Permanent vision loss or peripheral vision impairment
- Depression or mood changes
Risks and Warnings of Sabril
- Vision Loss: Regular monitoring of vision is crucial, as Sabril can cause progressive and permanent vision loss in some patients. Eye exams should be conducted before starting treatment and periodically thereafter.
- Psychiatric Effects: Monitor for any changes in mood or behavior, especially in patients with a history of depression or psychiatric disorders.
Interactions with Sabril
Common Drug Interactions
- Other CNS Depressants: Caution is advised when using Sabril with other central nervous system depressants, as this may enhance sedative effects.
- Anticonvulsants: Careful monitoring is necessary, as other anticonvulsants may alter the effectiveness of Sabril.
Alternatives to Sabril
- Other Anticonvulsants: Such as lamotrigine, carbamazepine, or levetiracetam, may be considered for similar indications based on the specific clinical scenario.
- Surgical Options: In some cases of refractory epilepsy, surgical interventions may be considered when medications are ineffective.
