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Rectiv
Rectiv (nitroglycerin) is a topical ointment used for the treatment of anal fissures (tears in the lining of the anus). Nitroglycerin acts as a vasodilator, helping to relax the smooth muscles in the anal area, thereby increasing blood flow and promoting healing. This medication is designed to relieve pain and discomfort associated with anal fissures and facilitate healing.
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Frequently Asked Questions
How quickly does Rectiv start to work?
Patients may begin to notice relief from pain within 15 to 30 minutes of application, but full healing of the fissure may take longer.
Can I use Rectiv while pregnant or breastfeeding?
Consult your healthcare provider before using Rectiv if you are pregnant, planning to become pregnant, or breastfeeding.
Are there any specific dietary restrictions while using Rectiv?
There are no specific dietary restrictions associated with the use of Rectiv; however, a diet high in fiber may help prevent further anal fissures.
What should I do if I miss a dose of Rectiv?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Rectiv safe for long-term use?
Rectiv is generally intended for short-term use for the treatment of anal fissures. Regular follow-up with a healthcare provider is recommended to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Rectiv Work?
- Releasing nitric oxide: When applied topically, nitroglycerin is converted to nitric oxide, which relaxes the smooth muscles in the anal sphincter and surrounding blood vessels.
- Increasing blood flow: This relaxation increases blood flow to the area, reducing pain and facilitating healing of the anal fissure.
Common Dosages
- Topical ointment: Usually available in a concentration of 0.4% nitroglycerin.
Typical Dosing
- The usual recommended dosing is to apply a thin layer of the ointment to the affected area two to three times daily, or as directed by a healthcare provider. It is important to apply it gently and to wash hands after application.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe pain associated with chronic anal fissures.
Who Shouldn't Take Rectiv?
- Known hypersensitivity to nitroglycerin or any components of the formulation.
- Increased intracranial pressure or severe anemia.
- Concurrent use of phosphodiesterase inhibitors (e.g., sildenafil) due to the risk of significant hypotension.
Advice From The Pharmacist
- Instruct patients on the proper technique for applying Rectiv, emphasizing the importance of using a small amount and avoiding excessive pressure.
- Advise patients to wash their hands thoroughly after application and to avoid touching their face or other areas where the ointment could cause unwanted effects.
- Discuss potential side effects, including headache, dizziness, or localized irritation, and encourage patients to report any severe or concerning symptoms.
Side Effects of Rectiv
Common Side Effects
- Headache
- Dizziness or lightheadedness
- Flushing of the skin
- Local irritation or rash at the application site
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Symptoms of hypotension (such as fainting or severe dizziness).
Risks and Warnings of Rectiv
- Headaches: Nitroglycerin is known to cause headaches, especially during the initiation of therapy. This side effect usually diminishes with continued use.
- Hypotension: Patients should be cautious when rising from a sitting or lying position, as nitroglycerin can cause dizziness or fainting due to lowered blood pressure.
Interactions with Rectiv
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, especially those that affect blood pressure or other nitrates, to avoid potential interactions.
Alternatives to Rectiv
- Other Treatments for Anal Fissures: Alternatives may include topical anesthetics, fiber supplements, sitz baths, and other medications aimed at promoting healing and pain relief, depending on the severity and persistence of the condition.
