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RabAvert
RabAvert is a rabies vaccine used for both pre-exposure prophylaxis (prevention) and post-exposure prophylaxis (treatment) against rabies infection. Rabies is a potentially fatal viral disease that affects the central nervous system, typically transmitted through the bite of an infected animal. RabAvert stimulates the body’s immune system to produce antibodies that can neutralize the rabies virus, providing protection against the disease. It is used both to prevent rabies before exposure and to provide immunity after potential exposure to the virus.
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Frequently Asked Questions
How long does the RabAvert vaccine provide protection?
For individuals receiving pre-exposure prophylaxis, booster doses may be needed every 2-3 years depending on ongoing risk of exposure. For post-exposure prophylaxis, the series provides long-term immunity after the full series is completed.
Can I get rabies even after receiving the RabAvert vaccine?
The RabAvert vaccine is highly effective in preventing rabies when the full vaccination series is completed. However, if you are exposed to rabies again in the future, you may need a booster series, especially if several years have passed since your vaccination.
What should I do if I miss a dose of RabAvert?
If you miss a dose of RabAvert during your vaccination schedule, contact your healthcare provider as soon as possible to reschedule. It’s important to stay on track to ensure full protection.
Can children receive RabAvert?
Yes, RabAvert is safe for children. The dosing and schedule are the same, though the injection site may be the thigh instead of the upper arm for young children.
Is RabAvert safe for pregnant or breastfeeding women?
RabAvert can be given during pregnancy if there is a significant risk of rabies exposure, and the benefits outweigh the risks. For breastfeeding women, RabAvert is also considered safe, but it’s best to discuss your situation with your healthcare provider.
Comprehensive Drug Guide
How Does RabAvert Work?
RabAvert works by stimulating the immune system to produce antibodies that can recognize and neutralize the rabies virus. The vaccine contains inactivated (killed) rabies virus, which is not infectious but capable of inducing an immune response. After vaccination, the immune system "learns" to recognize the rabies virus, and if the individual is exposed to the virus, the body can mount a rapid immune response to prevent infection.
Common Dosages
- Pre-exposure prophylaxis: A series of 3 doses given intramuscularly at days 0, 7, and 21 or 28.
- Post-exposure prophylaxis:
- For individuals who have never been vaccinated against rabies, a series of 5 doses given on days 0, 3, 7, 14, and 28.
- For individuals who have previously been vaccinated, a booster series of 2 doses given on days 0 and 3.
RabAvert is administered via intramuscular injection into the deltoid muscle (upper arm) in adults or the thigh in young children.
Typical Dosing
- Pre-exposure prophylaxis: A series of 3 doses (days 0, 7, and 21 or 28).
- Post-exposure prophylaxis:
- Unvaccinated individuals: A total of 5 doses (days 0, 3, 7, 14, and 28).
- Previously vaccinated individuals: A 2-dose booster series (days 0 and 3).
Rabies immune globulin (RIG) is often given alongside RabAvert for individuals who have never been vaccinated and are receiving post-exposure treatment.
Typical Dosing
FDA Approved Indications
- Pre-exposure prophylaxis against rabies in individuals at high risk of rabies exposure (e.g., veterinarians, animal handlers, travelers to areas where rabies is common).
- Post-exposure prophylaxis for individuals exposed to rabies, either through animal bites or other contact with potentially rabid animals.
Who Shouldn't Take RabAvert?
- Severe allergic reactions (anaphylaxis) to any components of the vaccine, such as egg protein or neomycin, or a previous rabies vaccine.
Advice From The Pharmacist
- Follow the full vaccination schedule as directed, especially for post-exposure prophylaxis. Skipping doses or not completing the series can leave you unprotected against rabies.
- Report any severe allergic reactions after receiving RabAvert, including rash, swelling, or difficulty breathing.
- Avoid strenuous activity for a day or two after vaccination if you experience soreness or swelling at the injection site.
- In cases of post-exposure prophylaxis, ensure that the rabies immune globulin (RIG) is administered as indicated, especially if it’s your first time receiving the rabies vaccine.
Side Effects of RabAvert
Common Side Effects
- Pain, redness, or swelling at the injection site
- Headache
- Dizziness
- Nausea
- Muscle pain or weakness
Uncommon/Severe Side Effects
- Severe allergic reactions: Rash, itching, swelling, or difficulty breathing.
- Neurological reactions: In extremely rare cases, Guillain-Barré syndrome (GBS), a neurological condition, has been reported following vaccination.
Risks and Warnings of RabAvert
- Severe allergic reactions: Individuals with a known allergy to vaccine components (such as egg protein or neomycin) should not receive RabAvert. Anaphylaxis, while rare, can occur and should be treated immediately if symptoms develop.
- Incomplete vaccination: Failing to complete the full vaccine schedule, particularly in post-exposure cases, may leave the individual at risk for developing rabies, which is almost always fatal once symptoms begin.
- Pregnancy: RabAvert can be administered during pregnancy if the risk of rabies exposure is high and the benefits outweigh the risks. Consult with a healthcare provider.
Interactions with RabAvert
Common Drug Interactions
- Immunosuppressive drugs: Medications that suppress the immune system (e.g., corticosteroids, chemotherapy) may reduce the effectiveness of the RabAvert vaccine. Patients taking these medications should discuss their situation with their healthcare provider to determine the best course of action.
- Rabies immune globulin (RIG): RabAvert is often given alongside RIG for post-exposure prophylaxis, particularly in individuals who have never been vaccinated against rabies. The two work together to provide immediate and long-term protection.
Alternatives to RabAvert
- Imovax Rabies: Another rabies vaccine used for both pre-exposure and post-exposure prophylaxis.
- Rabies immune globulin (RIG): Provides immediate passive immunity after rabies exposure and is often used with the rabies vaccine.
