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Quviviq
Quviviq (daridorexant) is a dual orexin receptor antagonist indicated for the treatment of insomnia in adults, characterized by difficulties with sleep onset and/or sleep maintenance. By selectively blocking the action of orexin, a neurotransmitter that promotes wakefulness, Quviviq helps improve sleep quality and duration, facilitating a more restful night's sleep.
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Frequently Asked Questions
How quickly does Quviviq start to work?
Patients may begin to feel the effects of Quviviq within 30 minutes to an hour after taking the medication.
Can I stop taking Quviviq suddenly?
Consult your healthcare provider before stopping Quviviq, especially if you have been taking it for an extended period.
Are there any specific dietary restrictions while using Quviviq?
There are no specific dietary restrictions associated with the use of Quviviq, but patients should avoid alcohol and central nervous system depressants.
What should I do if I miss a dose of Quviviq?
If you miss a dose, do not take an extra dose the next day. Take your usual dose the following night and continue with your regular schedule.
Is Quviviq safe for long-term use?
Quviviq can be safe for long-term use under medical supervision for managing insomnia, but regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Quviviq Work?
Blocking orexin receptors (OX1R and OX2R) in the brain, which decreases the effects of orexin. This action promotes sleep by inhibiting the wake-promoting pathways that orexin activates, leading to increased sleepiness and improved sleep maintenance.
Common Dosages
- Oral tablets: Common strengths include 25 mg and 50 mg.
Typical Dosing
- The recommended starting dose of Quviviq is 50 mg, taken orally once daily, 30 minutes before bedtime. Depending on individual response and tolerability, the dose may be adjusted to 25 mg if necessary.
Typical Dosing
FDA Approved Indications
- Treatment of insomnia in adults characterized by difficulty with sleep onset and/or sleep maintenance.
Who Shouldn't Take Quviviq?
- Known hypersensitivity to daridorexant or any components of the formulation.
- Severe hepatic impairment.
Advice From The Pharmacist
- Instruct patients to take Quviviq only when they are able to have a full night's sleep (7 hours or more) before the next day’s activities.
- Advise patients about the importance of avoiding alcohol and other central nervous system depressants while taking Quviviq to reduce the risk of excessive sedation.
- Discuss potential side effects, including drowsiness, dizziness, and potential next-day impairment, and encourage patients to report any severe or concerning symptoms.
Side Effects of Quviviq
Common Side Effects
- Drowsiness
- Fatigue
- Dizziness
- Headache
- Abnormal dreams
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Worsening of sleep apnea.
Risks and Warnings of Quviviq
- Next-Day Impairment: Quviviq may cause drowsiness the next day, particularly if the patient does not get a full night's sleep. Patients should avoid driving or operating heavy machinery until they know how the medication affects them.
- Risk of Dependence: Although not a controlled substance, long-term use of sleep medications can lead to tolerance or dependence; therefore, it is essential to use Quviviq under medical supervision.
Interactions with Quviviq
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, especially other sedatives, antihistamines, or medications that affect liver enzymes, as these can interact with Quviviq.
Alternatives to Quviviq
- Other Insomnia Treatments: Alternatives may include other classes of medications such as benzodiazepines, non-benzodiazepine sleep aids (like zolpidem or eszopiclone), and melatonin receptor agonists, depending on individual patient needs and the specific characteristics of their insomnia.
