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Qulipta
Qulipta (atogepant) is an oral medication used for the preventive treatment of episodic migraine in adults. It belongs to a class of drugs known as calcitonin gene-related peptide (CGRP) receptor antagonists. Qulipta works by inhibiting the action of CGRP, a molecule that plays a key role in the development of migraine attacks.
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Frequently Asked Questions
How quickly does Qulipta start to work?
Patients may begin to notice a reduction in migraine frequency within a few weeks of starting treatment, but it may take up to several weeks to see the full effect.
Can I stop taking Qulipta suddenly?
It is generally safe to stop taking Qulipta without tapering, but it is advisable to consult your healthcare provider regarding discontinuation.
Are there any specific dietary restrictions while taking Qulipta?
There are no specific dietary restrictions associated with Qulipta.
What should I do if I miss a dose of Qulipta?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Qulipta safe for long-term use?
Qulipta is designed for long-term use in the prevention of migraines. Regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Qulipta Work?
Atogepant works by selectively blocking CGRP receptors, preventing the binding of CGRP to its receptor. This inhibition reduces the vasodilation and inflammatory processes that contribute to the development of migraine headaches, thereby decreasing the frequency of migraine attacks.
Common Dosages
- Tablets: 10 mg, 30 mg, and 60 mg.
Typical Dosing
- The usual recommended dose for adults is 10 mg taken orally once daily. Based on the patient's response and tolerability, the dose may be increased to 30 mg or 60 mg once daily.
Typical Dosing
FDA Approved Indications
- Preventive treatment of episodic migraine in adults.
Who Shouldn't Take Qulipta?
- Known hypersensitivity to atogepant or any components of the formulation.
Advice From The Pharmacist
- Instruct patients to take Qulipta exactly as prescribed and to follow the dosing schedule for optimal effectiveness.
- Advise patients that it may take several weeks to notice the full benefits of the medication.
- Encourage patients to maintain a headache diary to track the frequency and severity of migraine attacks, which can be useful in assessing treatment efficacy.
Side Effects of Qulipta
Common Side Effects
- Nausea
- Fatigue
- Constipation
- Dry mouth
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Liver enzyme elevations; liver function tests should be monitored if indicated.
Risks and Warnings of Qulipta
- Liver Function: Patients with pre-existing liver conditions should be monitored closely, as there may be an increased risk of liver enzyme elevations.
- Efficacy Monitoring: Regular follow-ups are important to evaluate the effectiveness of the treatment and to assess any potential side effects.
Interactions with Qulipta
Common Drug Interactions
Other Medications: Caution should be exercised when using Qulipta with other medications that affect liver enzymes, as they may alter the metabolism of atogepant.
Alternatives to Qulipta
- Other CGRP Antagonists: Such as eptinezumab or fremanezumab may be considered based on patient-specific factors and response to therapy.
- Other Preventive Medications: Traditional migraine preventives, such as beta-blockers, antidepressants, or anticonvulsants, may also be options.
