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quiNINE Sulfate

QuiNINE Sulfate is an antimalarial medication primarily used for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum and other species. It has been used historically as a treatment for malaria and is derived from the bark of the cinchona tree. In addition to its antimalarial properties, quinine has analgesic and anti-inflammatory effects, though its use for these purposes is less common today.

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Frequently Asked Questions

How quickly does QuiNINE Sulfate start working?
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Patients may begin to notice improvement in malaria symptoms within a few days of starting treatment, but full recovery may take longer depending on the severity of the infection.

Can I stop taking QuiNINE Sulfate suddenly?
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It is important to complete the full course of treatment as prescribed to ensure the malaria infection is fully cleared. Consult your healthcare provider if you have concerns.

Are there any dietary restrictions while taking QuiNINE Sulfate?
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Are there any dietary restrictions while taking QuiNINE Sulfate? There are no specific dietary restrictions, but it's advisable to stay hydrated and maintain a balanced diet to support recovery.

What should I do if I miss a dose of QuiNINE Sulfate?
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If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Is QuiNINE Sulfate safe for long-term use?
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Long-term use of QuiNINE Sulfate is not generally recommended due to the potential for serious side effects. Regular monitoring by a healthcare provider is essential for those requiring prolonged treatment.

Comprehensive Drug Guide

How Does quiNINE Sulfate Work?

Quinine works by interfering with the parasite's ability to metabolize and digest hemoglobin in the red blood cells. It inhibits the formation of hemozoin, a detoxified product of hemoglobin degradation, leading to the accumulation of toxic metabolites that ultimately kill the malaria parasite. Quinine also affects the muscle contraction of the parasites, contributing to its antimalarial effect.

Common Dosages

  • Tablets: 324 mg (available as a sulfate salt)

Typical Dosing

  • For treating malaria: The typical dose is 648 mg (two 324 mg tablets) taken every 8 hours for 3 days, usually combined with another antimalarial agent.
  • For leg cramps: Dosing may vary; consult a healthcare provider for specific recommendations.


Typical Dosing

FDA Approved Indications

  • Treatment of acute uncomplicated malaria due to Plasmodium falciparum and other species.
  • Treatment of nocturnal leg cramps in some cases, though this indication is less common.


Who Shouldn't Take quiNINE Sulfate?

  • Known hypersensitivity to quinine or any of its components
  • History of severe thrombocytopenia or other blood disorders
  • Use in patients with myasthenia gravis or certain arrhythmias should be approached with caution.


Advice From The Pharmacist

  • Take QuiNINE Sulfate exactly as prescribed, and do not skip doses to ensure effective treatment of malaria.
  • Monitor for any signs of adverse reactions, such as changes in vision, tinnitus, or signs of blood disorders.
  • Discuss any other medications you are taking to avoid potential interactions, particularly with anticoagulants or other antimalarials.


Side Effects of quiNINE Sulfate

Common Side Effects

  • Nausea or vomiting
  • Headache
  • Dizziness or lightheadedness
  • Tinnitus (ringing in the ears)


Uncommon/Severe Side Effects

  • Hemolytic anemia
  • Severe allergic reactions (such as rash, itching, or swelling)
  • Cardiac arrhythmias


Risks and Warnings of quiNINE Sulfate

  • Cinchonism: Chronic use of quinine can lead to a condition known as cinchonism, characterized by tinnitus, headache, nausea, and visual disturbances.
  • Monitoring: Regular monitoring of blood counts and liver function is important, especially with prolonged use.
  • Pregnancy and Lactation: Consult with a healthcare provider regarding the use of quinine during pregnancy and breastfeeding due to potential risks to the fetus or infant.


Interactions with quiNINE Sulfate

Common Drug Interactions

  • Anticoagulants: Concomitant use with anticoagulants like warfarin may increase the risk of bleeding; monitor INR levels closely.
  • Cardiovascular Medications: Caution is advised when using quinine with medications that affect heart rhythm, as it may exacerbate arrhythmias.


Alternatives to quiNINE Sulfate

  • Other Antimalarial Medications: Such as artemisinin-based combination therapies (ACTs), which are now more commonly used for malaria treatment.
  • Chloroquine: Another option for specific types of malaria, though resistance may limit its effectiveness.