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Quelicin
Quelicin (succinylcholine) is a depolarizing neuromuscular blocker used primarily as a muscle relaxant in surgical procedures and during intubation. It facilitates rapid onset of muscle paralysis, allowing for easier manipulation of muscles during surgery or procedures that require anesthesia. Quelicin is particularly useful in emergency situations due to its quick action and short duration of effect.
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Frequently Asked Questions
How quickly does Quelicin work?
Quelicin typically takes effect within 30 to 60 seconds after administration, leading to rapid muscle paralysis.
Can I experience prolonged effects from Quelicin?
In some cases, especially in individuals with certain medical conditions, paralysis may be prolonged. Continuous monitoring is essential.
Are there any specific precautions I should take after receiving Quelicin?
Patients should be monitored closely during and after the procedure, particularly for respiratory function and muscle recovery.
What should I do if I have a history of malignant hyperthermia?
Inform your healthcare provider about your history, as alternative medications and additional precautions may be necessary.
Is Quelicin safe for everyone?
Quelicin is not suitable for individuals with specific contraindications, such as those with a history of malignant hyperthermia or certain neuromuscular disorders. Always discuss your medical history with your healthcare provider before administration.
Comprehensive Drug Guide
How Does Quelicin Work?
Succinylcholine works by mimicking acetylcholine at the neuromuscular junction, binding to the nicotinic receptors on the motor end plate. This binding leads to depolarization of the muscle membrane, causing an initial contraction followed by paralysis as the muscle becomes desensitized to further stimulation. The rapid onset and short duration of action make it effective for quick procedures.
Common Dosages
- Injectable solution: 20 mg/mL.
Typical Dosing
- The usual adult dosage for rapid sequence intubation is 1 to 1.5 mg/kg administered intravenously. The dosage may be adjusted based on patient factors, the procedure being performed, and the clinician's judgment.
Typical Dosing
FDA Approved Indications
- Facilitating tracheal intubation.
- Providing skeletal muscle relaxation during surgery or mechanical ventilation.
Who Shouldn't Take Quelicin?
- Known hypersensitivity to succinylcholine or any of its components.
- Personal or family history of malignant hyperthermia.
- Conditions that may predispose to prolonged paralysis, such as severe burns or neuromuscular diseases.
Advice From The Pharmacist
- Quelicin should only be administered by trained healthcare professionals in a controlled environment, such as a hospital or surgical center.
- Monitor the patient closely for any signs of adverse reactions, especially during the initial administration and recovery phases.
- Be aware of the risk of malignant hyperthermia; ensure that appropriate emergency protocols are in place.
Side Effects of Quelicin
Common Side Effects
- Muscle fasciculations (twitching)
- Pain at the injection site
- Bradycardia (slow heart rate)
- Increased intraocular pressure
Uncommon/Severe Side Effects
- Malignant hyperthermia (a severe reaction characterized by rapid muscle metabolism and high fever)
- Prolonged respiratory paralysis
- Cardiac arrest
Risks and Warnings of Quelicin
- Malignant Hyperthermia: Patients with a history of malignant hyperthermia should be carefully monitored, and alternative agents should be considered.
- Respiratory Effects: Because Quelicin can cause paralysis of the respiratory muscles, it is critical to ensure that adequate ventilation is provided.
- Electrolyte Imbalances: Monitor potassium levels as succinylcholine can cause hyperkalemia, particularly in patients with certain conditions.
Interactions with Quelicin
Common Drug Interactions
- Other Neuromuscular Blockers: Use with caution, as other neuromuscular blockers may interact and enhance the effects of succinylcholine.
- Anesthetics: Certain inhalational anesthetics may increase the neuromuscular blocking effects of succinylcholine.
Alternatives to Quelicin
- Non-Depolarizing Neuromuscular Blockers: Such as rocuronium or vecuronium, which may be used for similar purposes in surgical settings.
- Other Muscle Relaxants: Depending on the clinical scenario, different muscle relaxants may be employed.
