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Priftin
Priftin (generic name: rifapentine) is an antibiotic used in combination with other medications to treat tuberculosis (TB). It is a rifamycin antibiotic, similar to rifampin, and works by inhibiting bacterial RNA synthesis, ultimately killing the bacteria that cause tuberculosis. Priftin is typically used as part of a short-course treatment for latent or active tuberculosis to help prevent the development of drug resistance and ensure successful treatment.
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Frequently Asked Questions
How long does it take for Priftin to work?
Priftin begins working shortly after the first dose, but for tuberculosis, treatment typically lasts several months to ensure the infection is completely eradicated.
Can I take Priftin alone for tuberculosis?
No, Priftin should always be used in combination with other antibiotics to prevent the development of drug-resistant tuberculosis.
Does Priftin interact with other medications?
Yes, Priftin can interact with many medications, including oral contraceptives, antiretrovirals, and warfarin. Always inform your healthcare provider of all medications you are taking.
What should I do if I miss a dose?
If you miss a dose of Priftin, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Priftin safe during pregnancy?
Priftin may be used during pregnancy if the benefits outweigh the risks, but it should be discussed with your healthcare provider. Rifapentine can affect liver function and may increase the risk of adverse effects in pregnant women.
Comprehensive Drug Guide
How Does Priftin Work?
Priftin works by inhibiting bacterial RNA polymerase, an enzyme responsible for synthesizing RNA, which is essential for bacterial survival. By blocking RNA production, Priftin prevents the bacteria from multiplying, allowing the immune system and other antibiotics to clear the infection more effectively.
Common Dosages
- Tablets: 150 mg
Typical Dosing
- For latent tuberculosis infection, the typical dose is 900 mg (6 tablets) once weekly for 12 weeks, in combination with isoniazid.
- For active tuberculosis, Priftin is usually taken twice weekly in combination with other TB medications during the intensive phase of treatment.
Typical Dosing
FDA Approved Indications
- Treatment of latent tuberculosis infection (in combination with isoniazid).
- Treatment of active tuberculosis (in combination with other TB medications).
Who Shouldn't Take Priftin?
- Known hypersensitivity to rifapentine or any other rifamycin antibiotics (e.g., rifampin).
- Severe liver dysfunction unless under close monitoring by a healthcare provider.
Advice From The Pharmacist
- Take Priftin with food to improve absorption and reduce the risk of stomach upset.
- Because Priftin can cause red-orange discoloration of body fluids (e.g., urine, sweat, tears), it is important to inform patients that this is harmless but may stain clothing or contact lenses.
- Do not skip doses; completing the full course of treatment is essential to prevent the development of drug-resistant tuberculosis.
- Inform your healthcare provider if you experience any unusual fatigue, yellowing of the skin or eyes, or dark urine, as these may be signs of liver issues.
Side Effects of Priftin
Common Side Effects
- Red-orange discoloration of bodily fluids
- Nausea
- Diarrhea
- Fatigue
- Headache
Uncommon/Severe Side Effects
- Hepatotoxicity (liver toxicity)
- Severe allergic reactions (e.g., rash, difficulty breathing, swelling)
- Blood disorders (e.g., low platelet count)
Risks and Warnings of Priftin
- Hepatotoxicity: Priftin, like other rifamycins, may cause liver damage. Patients with pre-existing liver disease or those taking other hepatotoxic medications should be closely monitored with regular liver function tests.
- Drug Interactions: Priftin can interact with a wide range of medications by affecting liver enzymes that metabolize other drugs. These interactions can reduce the effectiveness of medications such as oral contraceptives or antiretrovirals.
- Development of Resistance: If Priftin is used alone or improperly, it can lead to the development of drug-resistant tuberculosis. Always use it in combination with other prescribed TB medications.
Interactions with Priftin
Common Drug Interactions
- Oral contraceptives: May reduce the effectiveness of birth control pills, increasing the risk of pregnancy.
- Antiretroviral drugs: May reduce the effectiveness of certain HIV medications (e.g., protease inhibitors).
- Warfarin: Priftin may reduce the effectiveness of warfarin, requiring dose adjustments and close monitoring of blood clotting times.
Alternatives to Priftin
- Rifampin: Another rifamycin antibiotic commonly used to treat tuberculosis.
- Isoniazid: A first-line antibiotic for both latent and active TB, often used in combination with rifapentine.
- Ethambutol: Used in combination with other TB drugs during the intensive phase of active tuberculosis treatment.
