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Prestalia
Prestalia is a combination medication that contains amlodipine and benazepril. It is used to treat hypertension (high blood pressure) and helps to lower blood pressure in individuals with essential hypertension. Amlodipine is a calcium channel blocker that relaxes blood vessels, while benazepril is an ACE (angiotensin-converting enzyme) inhibitor that helps prevent the constriction of blood vessels. Together, they work synergistically to improve blood flow and reduce blood pressure.
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Frequently Asked Questions
How quickly does Prestalia start to work?
Patients may begin to see a reduction in blood pressure within a few hours of taking Prestalia, but optimal effects are typically observed within a few weeks.
Can I stop taking Prestalia suddenly?
It is important not to discontinue Prestalia abruptly without consulting your healthcare provider, as this may lead to a rebound increase in blood pressure.
Are there any specific dietary restrictions while using Prestalia?
There are no specific dietary restrictions, but patients should be mindful of their sodium intake and follow a heart-healthy diet.
What should I do if I miss a dose of Prestalia?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Prestalia safe for long-term use?
Prestalia is generally safe for long-term use under medical supervision for managing hypertension. Regular follow-up appointments are essential to monitor blood pressure and assess any potential side effects.
Comprehensive Drug Guide
How Does Prestalia Work?
- Amlodipine works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to relaxation of blood vessels, reduced peripheral resistance, and decreased blood pressure.
- Benazepril inhibits the ACE enzyme, which converts angiotensin I to angiotensin II, a potent vasoconstrictor. By blocking this conversion, benazepril helps to lower blood pressure and decrease strain on the heart.
Common Dosages
- Tablets: Common strengths include 5 mg amlodipine / 10 mg benazepril and 5 mg amlodipine / 20 mg benazepril.
Typical Dosing
- The usual recommended starting dose is one tablet once daily, with the dosage adjusted based on blood pressure response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of hypertension in adults.
Who Shouldn't Take Prestalia?
- Known hypersensitivity to amlodipine, benazepril, or any components of the formulation.
- A history of angioedema related to previous ACE inhibitor therapy.
- Severe aortic stenosis.
Advice From The Pharmacist
- Instruct patients to take Prestalia as prescribed, and emphasize the importance of regular blood pressure monitoring to assess treatment effectiveness.
- Advise patients to report any signs of swelling (angioedema), persistent cough, or unusual fatigue.
- Discuss the importance of lifestyle modifications, such as diet and exercise, in conjunction with medication for optimal blood pressure control.
Side Effects of Prestalia
Common Side Effects
- Dizziness
- Fatigue
- Edema (swelling in the extremities)
- Headache
- Nausea
Uncommon/Severe Side Effects
- Angioedema (swelling of the face, lips, tongue, or throat)
- Severe hypotension (low blood pressure)
- Kidney dysfunction.
Risks and Warnings of Prestalia
- Blood Pressure Monitoring: Patients should be monitored for significant drops in blood pressure, especially after initiating treatment or increasing the dose.
- Kidney Function: Regular assessment of renal function is advised, particularly in patients with pre-existing renal impairment or those taking other medications that may affect kidney function.
Interactions with Prestalia
Common Drug Interactions
- Other Antihypertensives: Patients should inform their healthcare provider about all medications they are taking, especially other antihypertensive agents, as they can have additive effects on blood pressure.
- Potassium Supplements: Use of potassium supplements or potassium-sparing diuretics should be approached with caution, as they can increase the risk of hyperkalemia (high potassium levels).
Alternatives to Prestalia
- Other Antihypertensive Combinations: Alternatives may include other combinations of antihypertensives, such as amlodipine with lisinopril or hydrochlorothiazide, depending on individual patient needs and response.
