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Plexion NS

Plexion NS is a topical medication that combines sodium sulfacetamide and sulfur, primarily used to treat acne vulgaris and seborrheic dermatitis. The combination of these ingredients helps reduce acne lesions by targeting the bacteria that cause acne and by promoting the shedding of dead skin cells, thereby preventing clogged pores. Plexion NS is known for its effectiveness in managing oily and acne-prone skin.

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Frequently Asked Questions

How long does it take for Plexion NS to start working?
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Patients may begin to notice improvements in their acne within a few weeks, but it can take up to 12 weeks to see the full effects of treatment.

Can I use Plexion NS with other acne medications?
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Yes, but it is advisable to consult your healthcare provider before combining treatments to avoid excessive skin irritation.

Is Plexion NS safe for long-term use?
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Plexion NS can be used long-term under medical supervision, but regular follow-ups are important to monitor for effectiveness and any potential side effects.

What should I do if I miss a dose of Plexion NS?
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If you miss a dose, apply it as soon as you remember. If it’s almost time for your next application, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Are there any specific precautions I should take while using Plexion NS?
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Avoid contact with the eyes and mucous membranes, and use sunscreen to protect your skin from sun sensitivity while using this medication.

Comprehensive Drug Guide

How Does Plexion NS Work?

  • Sodium Sulfacetamide acts as a bacteriostatic agent that inhibits the growth of bacteria associated with acne, particularly Propionibacterium acnes.
  • Sulfur has keratolytic properties that help exfoliate the skin, reducing the buildup of dead skin cells that can lead to clogged pores and further acne formation. Sulfur also has antimicrobial properties, contributing to the overall effectiveness of the treatment.

Common Dosages

  • Topical lotion: 5% sodium sulfacetamide and 2% sulfur

Typical Dosing

  • Apply Plexion NS to the affected areas of the skin once or twice daily, as directed by a healthcare provider. It is essential to apply it to clean, dry skin and to follow up with a moisturizer if needed.


Typical Dosing

FDA Approved Indications

  • Acne vulgaris
  • Seborrheic dermatitis

Who Shouldn't Take Plexion NS?

  • Known hypersensitivity to sodium sulfacetamide, sulfur, or any of its components
  • Severe skin irritation or open wounds in the area of application

Advice From The Pharmacist

  • Shake the lotion well before each use to ensure proper mixing of the ingredients.
  • Apply a thin layer of the lotion to the affected areas and gently rub it in.
  • Avoid contact with the eyes and mucous membranes. If contact occurs, rinse thoroughly with water.
  • If you experience excessive dryness or irritation, consider reducing the frequency of application.

Side Effects of Plexion NS

Common Side Effects

  • Skin irritation or burning sensation
  • Dryness or peeling of the skin
  • Allergic reactions (such as rash or itching)


Uncommon/Severe Side Effects

  • Severe allergic reactions (such as swelling or difficulty breathing)


Risks and Warnings of Plexion NS

  • Skin Sensitivity: Use caution if you have sensitive skin or conditions that may exacerbate irritation, as sodium sulfacetamide and sulfur can be irritating.
  • Sun Sensitivity: Plexion NS may increase sensitivity to sunlight. Patients should use sunscreen and limit sun exposure while using this medication.
  • Superinfection: Monitor for signs of secondary bacterial infections if symptoms worsen during treatment.

Interactions with Plexion NS

Common Drug Interactions

  • Other Topical Medications: Be cautious when using other topical acne treatments, as they may increase skin irritation.
  • Medications Affecting Skin: Discuss the use of other products that may affect skin integrity or moisture levels with a healthcare provider.

Alternatives to Plexion NS

  • Benzoyl Peroxide: Another topical treatment that helps reduce acne through antibacterial action and by promoting skin cell turnover.
  • Salicylic Acid: A keratolytic agent that helps to exfoliate the skin and unclog pores.
  • Topical Retinoids: Such as tretinoin, which promote cell turnover and prevent the formation of new acne lesions.