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Phoslyra
Phoslyra (calcium acetate) is a phosphate binder used to manage hyperphosphatemia (elevated phosphate levels) in patients with chronic kidney disease (CKD) who are on dialysis. It helps to reduce the absorption of dietary phosphate by binding to it in the gastrointestinal tract, thereby lowering serum phosphate levels and helping to maintain bone and mineral health.
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Frequently Asked Questions
How quickly does Phoslyra start to work?
Phoslyra begins to work immediately upon ingestion, but serum phosphate levels may take several days to stabilize following consistent use.
Can I use Phoslyra while pregnant or breastfeeding?
Consult your healthcare provider before using Phoslyra if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Phoslyra?
While there are no specific dietary restrictions, patients should adhere to a phosphate-restricted diet as advised by their healthcare provider.
What should I do if I miss a dose of Phoslyra?
If you miss a dose, take it as soon as you remember with your next meal. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Phoslyra safe for long-term use?
Phoslyra is generally safe for long-term use in managing hyperphosphatemia in patients with CKD, but regular follow-ups with healthcare providers are essential to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Phoslyra Work?
- Binding dietary phosphate: Calcium acetate binds to phosphate in the intestine, forming insoluble complexes that are excreted in the feces, thus preventing phosphate absorption into the bloodstream. This action effectively reduces serum phosphate levels.
Common Dosages
- Liquid suspension: Common concentrations include 667 mg of calcium acetate per 5 mL.
Typical Dosing
- The usual recommended dosing is to take 2 to 4 teaspoons (10 mL to 20 mL) of Phoslyra with meals. The specific dosage may be adjusted based on the patient's serum phosphate levels and dietary intake.
Typical Dosing
FDA Approved Indications
- Management of hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis.
Who Shouldn't Take Phoslyra?
- Known hypersensitivity to calcium acetate or any components of the formulation.
- Severe hypercalcemia or calcium-related disorders.
Advice From The Pharmacist
- Instruct patients to take Phoslyra exactly as prescribed and to use it consistently with meals to maximize phosphate binding.
- Advise patients to monitor their dietary phosphate intake and to adhere to any dietary restrictions recommended by their healthcare provider.
- Discuss potential side effects, including gastrointestinal discomfort, constipation, or nausea, and encourage patients to report any severe or unusual symptoms.
Side Effects of Phoslyra
Common Side Effects
- Gastrointestinal upset (nausea, vomiting, constipation)
- Abdominal pain
- Dry mouth
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing).
- Symptoms of hypercalcemia (such as confusion, muscle weakness, or irregular heartbeat).
Risks and Warnings of Phoslyra
- Calcium Monitoring: Patients should have their serum calcium levels monitored regularly, especially if they have a history of calcium-related disorders.
- Drug Interactions: Calcium acetate may interact with other medications, so patients should inform their healthcare provider about all medications they are taking.
Interactions with Phoslyra
Common Drug Interactions
- Other Medications: Patients should avoid taking Phoslyra with certain medications, including tetracycline antibiotics or bisphosphonates, as calcium can bind to these medications and reduce their absorption.
Alternatives to Phoslyra
- Other Phosphate Binders: Alternatives may include other phosphate binders such as lanthanum carbonate, sevelamer, or aluminum hydroxide, depending on the patient's needs and response to therapy.
