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Pertzye
Pertzye is a pancreatic enzyme replacement therapy (PERT) used to help individuals with exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not produce enough enzymes to properly digest food. EPI can result from cystic fibrosis, chronic pancreatitis, or other conditions that affect pancreatic function. Pertzye contains a combination of digestive enzymes including lipase, protease, and amylase, which help the body break down fats, proteins, and carbohydrates from food.
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Frequently Asked Questions
How long does it take for Pertzye to start working?
Pertzye begins working with the first dose, helping to digest the food you eat. However, it may take a few days to notice full symptom relief as your digestion improves.
Can Pertzye be taken with all types of food?
Pertzye can be taken with most foods, but avoid mixing it with dairy products such as yogurt or milk, as these may interfere with the enzyme activity.
What should I do if I miss a dose of Pertzye?
If you forget to take Pertzye with a meal or snack, skip the missed dose and take your next dose with your next meal. Do not double up on doses to make up for the missed one.
Can Pertzye be used in children?
Yes, Pertzye is approved for use in both adults and children with exocrine pancreatic insufficiency. Dosing is often based on body weight and must be individualized for each patient.
Is it safe to take Pertzye long-term?
Yes, Pertzye is designed for long-term use in individuals with chronic conditions like cystic fibrosis or chronic pancreatitis. Regular follow-ups with your healthcare provider are necessary to adjust the dose if needed.
Comprehensive Drug Guide
How Does Pertzye Work?
Pertzye provides the body with exogenous pancreatic enzymes (lipase, protease, and amylase) that help digest fats, proteins, and carbohydrates. These enzymes are released in the small intestine, where they mimic the action of natural pancreatic enzymes, allowing nutrients to be absorbed properly. Pertzye's enteric-coated capsules protect the enzymes from stomach acid, ensuring they are released in the small intestine, where they are most effective.
Common Dosages
- 8,000 USP lipase units, 28,750 USP protease units, and 33,250 USP amylase units per capsule
- 16,000 USP lipase units, 57,500 USP protease units, and 66,500 USP amylase units per capsule
Typical Dosing
- The dose of Pertzye is individualized based on the severity of enzyme deficiency and body weight. It is typically taken with meals and snacks.
- Initial dosing is often based on lipase units per kilogram of body weight. Common starting doses for meals range from 500 to 2,500 lipase units/kg per meal.
- For snacks, half of the meal dose is usually recommended.
- Always take Pertzye with food to ensure the enzymes are present to digest the meal.
Typical Dosing
FDA Approved Indications
- Treatment of exocrine pancreatic insufficiency (EPI) due to conditions like cystic fibrosis and chronic pancreatitis.
Who Shouldn't Take Pertzye?
- Known hypersensitivity to pork proteins (since the enzymes are derived from pig pancreas).
- Hypersensitivity to any of the components in Pertzye.
Advice From The Pharmacist
- Take Pertzye with every meal or snack to ensure the enzymes help digest food effectively.
- Swallow the capsules whole with enough liquid to ensure proper digestion. If you cannot swallow the capsules, you may open them and sprinkle the contents on a small amount of soft, acidic food (e.g., applesauce). Do not crush or chew the contents.
- Do not mix the contents with dairy products such as milk or yogurt, as this may affect how the enzymes work.
- Store Pertzye at room temperature and away from moisture to protect the enzymes from degradation.
Side Effects of Pertzye
Common Side Effects
- Stomach pain
- Bloating
- Diarrhea or constipation
- Nausea
Uncommon/Severe Side Effects
- Fibrosing colonopathy: A rare condition where the colon becomes narrowed, typically seen in patients with cystic fibrosis who take high doses of pancreatic enzyme replacement therapy. Contact your healthcare provider if you experience severe abdominal pain or changes in bowel habits.
- Allergic reactions: Symptoms may include rash, itching, swelling, or difficulty breathing.
Risks and Warnings of Pertzye
- Fibrosing colonopathy: High doses of pancreatic enzyme replacement therapy (particularly lipase >6,000 units/kg/meal) have been associated with the development of fibrosing colonopathy. Patients with cystic fibrosis taking high doses of Pertzye should be monitored for this condition.
- Pork allergy: Since Pertzye is derived from porcine (pig) pancreas, patients with a pork allergy should avoid this medication.
- Potential for viral transmission: Though rare, there is a theoretical risk of viral transmission from animal-derived enzymes. Proper manufacturing processes are used to minimize this risk.
Interactions with Pertzye
Common Drug Interactions
- Antacids: Taking Pertzye with antacids that contain calcium carbonate or magnesium hydroxide may reduce the effectiveness of the enzymes by increasing the stomach's pH, which can prevent the capsules from dissolving properly.
- Iron supplements: High doses of iron supplements may reduce the absorption of certain enzymes in Pertzye, potentially decreasing its effectiveness.
Alternatives to Pertzye
- Creon: Another pancreatic enzyme replacement therapy available in various strengths for the treatment of exocrine pancreatic insufficiency.
- Zenpep: Another option for treating EPI with different strengths of enzyme combinations.
- Pancreaze: A pancreatic enzyme product used to treat EPI that also contains lipase, protease, and amylase in varying doses.
