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Paxlovid (150/100)
Paxlovid is an oral antiviral medication that combines nirmatrelvir and ritonavir. It is primarily used for the treatment of mild to moderate COVID-19 in patients at high risk of progressing to severe disease. Paxlovid is intended to reduce the severity of the illness and the risk of hospitalization.
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Frequently Asked Questions
How quickly does Paxlovid work?
Paxlovid is most effective when taken as soon as possible after the onset of COVID-19 symptoms, ideally within the first five days.
Can I take Paxlovid if I'm already vaccinated?
Yes, Paxlovid can be prescribed for vaccinated individuals who are at high risk for severe disease if they contract COVID-19.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is Paxlovid safe during pregnancy?
Consult your healthcare provider before using Paxlovid during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions or liver issues, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Paxlovid (150/100) Work?
- Nirmatrelvir: A protease inhibitor that inhibits the SARS-CoV-2 protease, preventing viral replication.
- Ritonavir: Boosts the effectiveness of nirmatrelvir by inhibiting its metabolism, allowing for increased plasma levels and prolonging its action.
What is Paxlovid (150/100) Used For?
Common Dosages
- Oral tablets: Each dose of Paxlovid consists of two nirmatrelvir tablets (150 mg each) and one ritonavir tablet (100 mg).
Typical Dosing
- Adults and Children (12 years and older): The usual dose is 300 mg of nirmatrelvir (two 150 mg tablets) and 100 mg of ritonavir (one 100 mg tablet), taken together twice daily for 5 days.
Typical Dosing
FDA Approved Indications
- Treatment of mild to moderate COVID-19 in adults and pediatric patients (aged 12 years and older) who are at high risk for progression to severe COVID-19.
Pediatric Dosing
Who Shouldn't Take Paxlovid (150/100)?
- Known hypersensitivity to nirmatrelvir, ritonavir, or any component of the formulation.
- Significant drug interactions, particularly with certain medications that are contraindicated with ritonavir.
Advice From The Pharmacist
- Take Paxlovid exactly as prescribed, and complete the full course of treatment.
- Inform your healthcare provider about all medications you are taking to avoid potential interactions, especially with drugs that may affect liver enzymes.
- Monitor for any worsening symptoms and seek medical advice if needed.
Side Effects of Paxlovid (150/100)
Common Side Effects
- Altered taste
- Diarrhea
- Hypertension
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Liver enzyme elevations
Risks and Warnings of Paxlovid (150/100)
- Drug Interactions: Ritonavir can interact with many medications, leading to significant side effects or reduced efficacy. Regularly review all medications with your healthcare provider.
- Liver Function: Monitor liver function tests as needed, especially in patients with liver conditions.
Interactions with Paxlovid (150/100)
Common Drug Interactions
- CYP3A4 Inhibitors/Inducers: Be cautious when taking medications that may affect the metabolism of Paxlovid, as these can alter its effectiveness.
- Other Protease Inhibitors: Avoid using other protease inhibitors concurrently without medical supervision.
Alternatives to Paxlovid (150/100)
- Other Antivirals: Such as remdesivir for hospitalized patients with COVID-19.
- Monoclonal Antibodies: Alternative treatments for COVID-19 depending on specific clinical circumstances.
