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Parnate
Parnate is a brand name for tranylcypromine, a monoamine oxidase inhibitor (MAOI) used primarily to treat major depressive disorder. It is particularly effective for atypical depression and depression that has not responded to other treatments.
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Frequently Asked Questions
How quickly does Parnate work?
Patients may start to notice improvements in their depressive symptoms within 2 to 4 weeks of starting treatment.
Can I take Parnate with food?
While it can be taken with food, you must avoid tyramine-rich foods to prevent hypertensive crisis.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. Do not double up on doses.
Are there any dietary restrictions while using Parnate?
Yes, you should avoid tyramine-rich foods and beverages to reduce the risk of hypertensive crisis.
Is Parnate safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Parnate during these periods.
Comprehensive Drug Guide
How Does Parnate Work?
Tranylcypromine works by inhibiting the enzyme monoamine oxidase, which is responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. By preventing the breakdown of these neurotransmitters, Parnate increases their levels, helping to alleviate depressive symptoms.
Common Dosages
- Tablets: Common strengths include 10 mg.
Typical Dosing
- The usual starting dose is 30 mg per day, divided into two or three doses. The dosage may be adjusted based on clinical response, with a maximum recommended dose of 60 mg per day.
Typical Dosing
FDA Approved Indications
- Major Depressive Disorder: for the treatment of depression in adults.
Who Shouldn't Take Parnate?
- Known hypersensitivity to tranylcypromine or any component of the formulation.
- Severe hepatic or renal impairment.
- Concurrent use of other MAOIs or certain medications (e.g., certain antidepressants, stimulants).
Advice From The Pharmacist
- Follow the prescribed dosing regimen carefully, and do not discontinue the medication abruptly without consulting your healthcare provider.
- Monitor for any signs of hypertensive crisis, such as severe headache, neck stiffness, or palpitations, especially after consuming tyramine-rich foods.
- Discuss any other medications or supplements you are taking with your healthcare provider to avoid dangerous interactions.
Side Effects of Parnate
Common Side Effects
- Dizziness
- Dry mouth
- Insomnia
- Weight gain
- Constipation
Uncommon/Severe Side Effects
- Hypertensive crisis (severe hypertension)
- Serotonin syndrome (especially when combined with other serotonergic medications)
- Liver toxicity.
Risks and Warnings of Parnate
- Dietary Restrictions: Patients taking Parnate must adhere to a strict diet low in tyramine to avoid hypertensive crisis, which can occur when tyramine-rich foods (such as aged cheeses, cured meats, and certain alcoholic beverages) are consumed.
- Monitoring Required: Regular monitoring of blood pressure is recommended, especially during the initial treatment period.
Interactions with Parnate
Common Drug Interactions
- Other Antidepressants: Avoid combining with other antidepressants, particularly SSRIs and SNRIs, due to the risk of serotonin syndrome.
Common Food Interactions
- Tyramine-Rich Foods: Consumption can lead to hypertensive crisis.
Alternatives to Parnate
- Other Antidepressants: Such as SSRIs, SNRIs, or atypical antidepressants for managing major depressive disorder.
- Psychotherapy: Cognitive behavioral therapy (CBT) or other therapeutic approaches can also be effective in treating depression.
